Duplication of the Pylorus: An Elusive Diagnosis

Dc, Keramidas; Nl, Doulas; Anagnostou, D.

doi:10.1055/s-2008-1066316

Cited by 3 publications

(3 citation statements)

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“…[2] The demography, presentation, diagnosis, surgical management, histology, and outcome of cases of neonatal pyloric duplication that have been mentioned in the literature has been tabulated in Table1. [1,4,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] In the present case, the child was taken up for surgery with suspicion of a duodenal duplication cyst, however, an intraluminal pyloric duplication cyst was discovered and excised. The histopathology of the excised cyst showed Brunner's gland in submucosa and the muscularis layer was present suggestive of a duplication cyst.…”

Section: Discussionmentioning

confidence: 99%

Intraluminal pyloric duplication cyst- a rare cause of non-bilious vomiting in a neonate: A case report

et al. 2021

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Background: Duplications of the alimentary tract are rare congenital malformations, out of which, true pyloric duplications constitute only 2.2%. They present with non-bilious vomiting and mimic hypertrophic pyloric stenosis (HPS). Pyloric duplications that are intraluminal are not separately visible at laparotomy, making their diagnosis difficult. Case presentation: Our case is a neonate with an intraluminal pyloric duplication cyst who presented with recurrent vomiting. The radiological evaluation suggested a duplication cyst medial to the second part of the duodenum towards the stomach’s lesser curvature with features of gastric outlet obstruction. Intraoperatively, a cystic mass of 1 x 2 cm intraluminally was found on opening the pylorus which was excised and pyloroplasty was done. Postoperatively the baby was discharged in a stable condition. Conclusion: Intraluminal pyloric duplication cysts are rare and the clinical presentation mimics HPS. They should be considered as a differential diagnosis in a neonate presenting with features of gastric outlet obstruction.

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Section: Discussionmentioning

confidence: 99%

Intraluminal pyloric duplication cyst- a rare cause of non-bilious vomiting in a neonate: A case report

et al. 2021

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“…Some GID may be totally asymptomatic, identified on routine physical examination or during investigations for other problems. Common clinical manifestations of pyloric duplications include a palpable abdominal mass and non bilious vomiting which is almost present in all the cases of literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Bleeding, intussusception can be an occasion for discovering such unusual anomalies [3,20].…”

Section: Case Reportmentioning

confidence: 99%

“…In most cases preoperative diagnosis is not made [2]. To our knowledge, no more than 20 cases of pyloric duplication have been reported in the English literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18], most of them were extra luminal masses. Here in, we describe two cases with pyloric duplication cyst.…”

Section: Introductionmentioning

confidence: 99%

Pyloric Duplication: About Two Cases

Ahmed¹,

Ghorbel²,

Charieg³

et al. 2015

JPNC

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Pyloric duplication cyst is a rare congenital anomaly. Few cases have been described in the literature. We report two cases of 2 and 5 year-old girl. The diagnosis was suspected on ultra sonography and upper gastrointestinal series and confirmed by surgery and histopathologic examination. Resection was total in one case and partial in the other. Pyloroplasty was associated. Post operative was unfaithful.

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Intracellular Sensing and Transport of Amino Acids and the Downstream Effects on mTORC1 Activation: Implications for Muscle Protein Synthesis

Hwang

Willoughby

2015

JNHFE

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The mTOR pathway and its impact on mps The mammalian target of rapamycin (mTOR) signaling pathway has attracted considerable attention due to its involvement in regulating muscle protein synthesis (MPS). 1,2 Additionally, this protein kinase is also involved in regulating various intramuscular and developmental processes such as gene transcription, mRNA translation, cell proliferation, metabolism, and repression of autophagy. 3 There is substantial evidence demonstrating that mTOR is similar to a "master switch" mediating the balance between intramuscular anabolic and catabolic processes due to its complex ability to sense mitogen, energy, and nutrient levels. 4,5 Several studies have demonstrated that amino acids, such as L-leucine, or heightened activity of mitogen activity (growth factors such as IGF-1 or insulin) can activate the signaling cascade of mTOR for subsequent increases in protein translation initiation. Furthermore, concomitant to this augmented rate of protein translation initiation, skeletal muscle protein turnover can also increase the positive net protein balance over time. 6 However, it is generally understood that these mitogens seem to act upon different substrates upstream or downstream from mTOR. With respect to the mTOR signaling pathway, growth factors such as insulin or IGF-1 are known to bind their respective receptors, which would trigger the activation of various kinases, phosphatidylinositol-3 kinase (PI3K) in particular. 4,7 Activated PI3K catalyzes the conversion of membrane phospholipid phosphatidylinositol-4,5-biphosphate (PIP2) into phosphatidylinositol-3,4,5-triphosphate (PIP3), which would open a lipid-binding membrane site for effector protein kinase B (Akt). 7,8 The increased levels of PIP3, and activity of phosphoinositide-dependent kinase 1 (PDK1) and PDK2, lead to the activation of Akt. 5,9 Therefore, this growth factor signaling cascade culminates in a positive regulatory function of mTOR due to activated levels of PI3K and Akt. Activation of mTORC1 results in phosphorylation of the downstream effectors, eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and the phosphorylated ribosomal protein S6 (p70S6K). As such, 4E-BP1 is known as an inhibitor of the mRNA cap-binding protein eIF4E. 5,8,10 Moreover, the stimulation of 4E-BP1 results in the release of eukaryotic initiation factor 4E (eIF4E), which subsequently enables the recruitment to the second initiation factor, eIF4G. 11-15 This formulates into the multi-protein complex known as the eIF4F

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Duplication of the Pylorus: An Elusive Diagnosis

Cited by 3 publications

References 0 publications

Intraluminal pyloric duplication cyst- a rare cause of non-bilious vomiting in a neonate: A case report

Intraluminal pyloric duplication cyst- a rare cause of non-bilious vomiting in a neonate: A case report

Pyloric Duplication: About Two Cases

Intracellular Sensing and Transport of Amino Acids and the Downstream Effects on mTORC1 Activation: Implications for Muscle Protein Synthesis

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