Dupuytren, Ledderhose, and Peyronie Diseases After Primidone Use For Essential Tremor

Abstract

Introduction: Dupuytren, Ledderhose, and Peyronie diseases are chronic fibrotic conditions related to progressive fibrosis of the palmar fascia, plantar fascia, and tunica albuginea, respectively. These conditions have been associated with antiepileptic drug use, mainly phenobarbital and primidone. Case Report: A 71-year-old man developed simultaneous Dupuytren, Ledderhose, and Peyronie diseases after primidone use for essential tremor. Conclusions: There are a few reports associating barbiturate use to connective tissue disorders, and some suggest that drug withdrawal may result in a better prognosis. Therefore, physicians must be aware of such adverse events when caring for patients on long-term barbiturate use.

Primidone Intolerance in Essential tremor: Is it More than Just Age?

“…While sedation is a common ADR, and it is usually dose-related, some patients develop other neurotoxic effects such as nausea, vomiting, dizziness, and ataxia [21]. In addition, rare occurrence of connective tissue disorders and a lupus-like illness, as a side effect of long-term use of primidone, have been reported [24,25]. Almost all studies have reported primidone-related ADRs and, based on the timing of onset, these ADRs may be divided into two types.…”