Dupuytren'S Contracture; Increased Cellularity — Proliferation, is There Equality?

Forsman, Minna; Kallioinen, Leena; Kallioinen, Matti; Ryhänen, Jorma

doi:10.1177/145749690509400117

Cited by 4 publications

(5 citation statements)

References 32 publications

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“…Higher levels of tenascin protein have been observed in more aggressive forms of DD,30 which is in agreement with upregulation of tenascin C mRNA and downregulation of microRNA targeting TNC 9 13 14. Similarly, TGFB2 mRNA has been shown to be upregulated in DD,12 and shows intense intracellular localisation within myofibroblasts in the proliferative and involutional stages of the disease 26.…”

Section: Comparing Global Rna Expression With Protein Expressionmentioning

confidence: 52%

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Whole genome and global expression profiling of Dupuytren's disease: systematic review of current findings and future perspectives

2012

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Dupuytren's disease (DD) is a common fibroproliferative disorder affecting the palmar fascia, which may lead to permanent contracture of the affected digit. Profiling studies investigating DD at whole-genomic, transcriptomic and proteomic levels have been carried out, from which large numbers of candidate genes potentially involved in DD have been reported. This review focuses on identifying genes reported by multiple studies or validated by multiple experimental techniques, as well as signalling pathways suggested to contribute to DD. Meta-analysis was also carried out on three microarray datasets. Twenty-one genes were found to be reported as dysregulated in multiple gene expression microarrays, seven of which have been further validated by other experimental methods. Sixty-four genes determined to be dsyregulated by meta-analysis correlate to those reported by published microarray studies. In addition, several pathways have been proposed to be involved in DD by whole-genome or global expression profiling. Further investigation in these genes and pathways, and correlating them to genotypes or environmental factors for DD, may aid in further elucidation of mechanisms involved in DD pathogenesis.

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Section: Comparing Global Rna Expression With Protein Expressionmentioning

confidence: 52%

“…ECM surrounding alpha smooth muscle actin-positive cells in proliferative nodules demonstrate staining of type IV collagen, laminin and tenascin 28 29. Several immunohistological studies investigate specific ECM in DD 27–30. Pathological collagen deposition has been associated with DD 31.…”

Section: Comparing Global Rna Expression With Protein Expressionmentioning

confidence: 99%

Whole genome and global expression profiling of Dupuytren's disease: systematic review of current findings and future perspectives

2012

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“…Various factors have been proposed to play role in post-operative clinical recurrence (26,27). One of these factors is the relationship between myofibroblasts and intracellular microtubules.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of myofibroblast in residual tissue can be used to predict the likelihood of recurrence. For this reason, radical excision of the palmar fascia and the involved skin zone with open surgery method and covering the surgery zone with fullthickness skin graft is useful in preventing the contracture (26).…”

Section: Discussionmentioning

confidence: 99%

Palmar Fibromatosis: an Analysis of 25 Cases

Balık¹,

Bedir²

2019

eamr

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Objective: Dupuytren's contracture (DC) is a benign tumor that results in nodular or fibrous band-like thickening of the palmar fascia and leads to palmar and digital contractures. Although they are benign lesions, post-operative recurrence is frequent. In the present study, we retrospectively analyzed clinicopathological findings of 25 cases that underwent surgery for DC. We also aimed to determine the relationship between relapse and Ki-67 proliferation index and smooth muscle actin (SMA) staining intensity in excision materials by immunohistochemical method. Methods: The demographic characteristics, severity of contracture, treatment type, Ki-67 proliferation index, SMA staining intensity and recurrence were evaluated retrospectively in 25 patients who were operated with the diagnosis of DC at the Department of Orthopedics and Traumatology in Recep Tayyip Erdogan University between 2009 and 2015. Results: The age range of the patients was 42-75 years (mean age: 55 years), and 6 were female and 19 were male. Fifteen of the lesions were in the right hand, and 10 were in the left hand. All patients underwent extensive palmar fascia excision with regional intravenous anesthesia. Only one patient had recurrence. Ki-67 proliferation index was 1-2% in patients without recurrence, however, >5% nuclear positivity was detected in a patient with recurrence. In addition, strong positive staining for SMA was observed in this patient. Conclusion: The use of Ki-67 proliferation index and SMA staining intensity to evaluate fibroblastic proliferation in the pathological examination of surgical DC specimens may be valuable in clinical follow-up in terms of recurrence.

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“…The lesion in DD are located along the lines of longitudinal tensions of the hand [3,19,20]. This is caused by the shortening of the structure of the palmar fascia.…”

Section: Introductionmentioning

confidence: 99%

An effectiveness evaluation of the palmar fascia irradiation of patients suffering from Dupuytren’s disease

Latusek

Miszczyk²,

Gierlach³

et al. 2017

Nowotwory. Journal of Oncology

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Dupuytren'S Contracture; Increased Cellularity — Proliferation, is There Equality?

Abstract: There may be differences in the histology and/or immunohistochemical appearance of pathological palmar connective tissue cords in aggressive and normal Dupuytren's disease. Further studies are needed to elucidate the pathogenesis of this disease.

Cited by 4 publications

References 32 publications

Whole genome and global expression profiling of Dupuytren's disease: systematic review of current findings and future perspectives

Whole genome and global expression profiling of Dupuytren's disease: systematic review of current findings and future perspectives

Palmar Fibromatosis: an Analysis of 25 Cases

An effectiveness evaluation of the palmar fascia irradiation of patients suffering from Dupuytren’s disease

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