Dupuytren’s Disease

Thurston, A. J.

doi:10.1302/0301-620x.85b4.14215

Cited by 83 publications

(73 citation statements)

References 84 publications

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“…[8][9][10] Environmental factors known to affect the development of DD include repeated hand injuries, diabetes, epilepsy, alcohol consumption, and tobacco use. [11][12][13] These factors play a role in inflammation, fibrosis, cellular trauma, and ischemia, affecting the interaction between the myofibroblast and collagen matrix. Altered regulation of growth factor pathways, such as transforming growth factor-β and epidermal growth factor, stimulate extracellular matrix formation and myofibroblast activity, increasing the severity of DD.…”

mentioning

confidence: 99%

SNPs Previously Associated with Dupuytren's Disease Replicated in a North American Cohort

Anderson

Caldwell

et al. 2014

Clinical Medicine & Research

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mentioning

confidence: 99%

SNPs Previously Associated with Dupuytren's Disease Replicated in a North American Cohort

Anderson

Caldwell

et al. 2014

Clinical Medicine & Research

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“…A Swedish study (3) has shown a prevalence of 6 % in the population. Appreciable risk factors are diabetes mellitus (4), heredity (5), alcohol and smoking (6). Dupuytren's contracture starts in the palm of the hand and causes a contracture of the metacarpophalangeal (MCP) joint.…”

mentioning

confidence: 99%

Evaluation of Activity Limitation and Digital Extension in Dupuytren's Contracture Three Months after Fasciectomy and Hand Therapy Interventions

Engstrand¹,

Borén²,

Liedberg³

2009

Journal of Hand Therapy

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“…D upuytren's disease (DD) is a common condition with 4% to 6% of Caucasian populations having evidence of disease, 1 and affecting up to 20% of men older than 65 years of age. 2 Clinically it is characterized by fibrosis of the palmar fascia; progression and potentially onset of the disease involves the formation and proliferation of myofibroblasts.…”

mentioning

confidence: 99%

A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease

Johnston

Chojnowski

Davidson

et al. 2007

The Journal of Hand Surgery

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Purpose: Dupuytren's disease (DD) is a common fibrotic condition of the palmar fascia, leading to deposition of collagen-rich cords and finger contractions. The metzincin superfamily contains key enzymes in the turnover of collagen and other extracellular matrix macromolecules. A number of broad-spectrum matrix metalloproteinase inhibitors, used in cancer clinical trials, caused side effects of DD-like contractures. We tested the hypothesis that changes in the expression of specific metalloproteinases underlie or contribute to the fibrosis and contracture seen in DD. Methods: We collected tissue from patients with DD and used normal palmar fascia as a control. We profiled the expression of the entire matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinases (TIMP), and a disintegrin and metalloproteinase domain with thrombospondin motif (ADAMTS) gene families in these tissues using real-time reversetranscription polymerase chain reaction. Results: A number of metalloproteinases and inhibitors are regulated in DD. The expression of 3 key collagenases, MMP1, MMP13, and MMP14 is increased significantly in the DD nodule, as is the expression of the collagen biosynthetic enzyme ADAMTS14. The expression of MMP7, an enzyme with broad substrate specificity, is increased in the DD nodule and remains equally expressed in the DD cord. TIMP1 expression is increased significantly in DD nodule compared with normal palmar fascia. Conclusions: This study measured the expression of all MMP, ADAMTS, and TIMP genes in DD. Contraction and fibrosis may result from: (1) increased collagen biosynthesis mediated by increased ADAMTS-14; (2) an increased level of TIMP-1 blocking MMP-1-and MMP-13-mediated collagenolysis; and (3) contraction enabled by MMP-14 -mediated pericellular collagenolysis (and potentially MMP-7), which may escape inhibition by TIMP-1. The complete expression profile will provide a knowledge-based approach to novel therapeutics targeting these genes. (J Hand Surg 2007;32A:343-351.

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Dupuytren’s Disease

Cited by 83 publications

References 84 publications

SNPs Previously Associated with Dupuytren's Disease Replicated in a North American Cohort

SNPs Previously Associated with Dupuytren's Disease Replicated in a North American Cohort

Evaluation of Activity Limitation and Digital Extension in Dupuytren's Contracture Three Months after Fasciectomy and Hand Therapy Interventions

A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease

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