Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants.

Critchley, E. M. R.; Vakil, S. D.; Hayward, H W; Owen, Valerie M.

doi:10.1136/jnnp.39.5.498

Cited by 73 publications

(40 citation statements)

References 7 publications

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“…There is a greater tendency for DD to be bilateral and symmetrical, 29 and its incidence increases with the duration of epilepsy. 30 Furthermore, DD occurs in all forms of epilepsy (including non-familial forms) with equal frequency, and there is no correlation with the severity of the epilepsy. 28 There are no reports of anticonvulsant drugs increasing the incidence of DD in races other than white people.…”

Section: Epilepsymentioning

confidence: 99%

Clinical associations of Dupuytren’s disease

Hart

Hooper

2005

Postgraduate Medical Journal

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Dupuytren’s disease (DD) is a common progressive fibrotic condition affecting the palmar and digital fascia. Although its management is undertaken by hand surgeons, it is commonly seen by other doctors as an incidental finding. In many cases it is believed to be associated with other medical conditions, although the evidence for such associations is not always clear. This review considers the evidence behind these associations and discusses the aetiology of DD. By doing so, it is hoped that this review will permit a better understanding of the relevance of DD as a clinical sign.

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Section: Epilepsymentioning

confidence: 99%

Clinical associations of Dupuytren’s disease

Hart

Hooper

2005

Postgraduate Medical Journal

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“…Each adjusted grade was scored from 3 (moderate) to 20 (extreme 10) (table 1). From these details, the score assigned to each adjusted technical grade (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) was multiplied by the average number of days a year that the climber had spent climbing at that grade for each decade. The same was calculated for every decade that each climber had climbed for his or her whole climbing career to date.…”

Section: Climbing Intensity Calculationsmentioning

confidence: 99%

Can rock climbing lead to Dupuytren’s disease?

Logan

Mason²,

Dias³

et al. 2005

Br J Sports Med

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Objectives: To determine if rock climbing is a significant factor in the development of Dupuytren's disease in men, and, if so, what is the most likely related factor. Methods: Questionnaires were distributed to all 1100 members of the Climbers' Club of Great Britain. These detailed basic information about the climber, the presence of Dupuytren's disease, and any known risk factors for its development. Results: About half (51%) of the questionnaires were returned. The respondents were almost entirely male. It was revealed that 19.5% of male climbers had developed Dupuytren's disease. There was a significantly higher life time intensity of climbing activity in those with the disease. An earlier age of onset of the disease was found in climbers compared with the general population. Conclusions: This study further strengthens the hypothesis that repetitive trauma to the palmar fascia predisposes to the development of Dupuytren's disease in men.

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“…9,10 . Em pacientes não epilépticos a incidência de doenca de Dupuytren tem sido estimada entre 0,5% (mulheres na menopausa), 1 % (homens adultos jovens), 9% (mulheres acima de 75 anos) e 18% (homens acima de 75 anos) 11 . Critchley e col. em 1976 relataram incidência de 56% em 361 pacientes epilépticos crônicos e todos haviam recebido barbitúricos como monoterapia ou em combinação com outras drogas.…”

Section: Relato Do Casounclassified

“…Critchley e col. em 1976 relataram incidência de 56% em 361 pacientes epilépticos crônicos e todos haviam recebido barbitúricos como monoterapia ou em combinação com outras drogas. Nenhum dos 19 pacientes que não haviam sido tratados com barbitúricos apresentaram contraturas 11 . Alguns autores acreditavam ser a contratura relacionada com o tipo de epilepsia, sua duração e tempo de tratamento 8,10 .…”

Section: Relato Do Casounclassified

“…Blanquart e colaboradores observaram que 11 de 16 pacientes melhoraram dentro de 1 a 4 meses após a terapia com fenobarbital ter sido suspensa e os outros melhoraram mais tarde 12 . O grande aumento de relatos desta doença após 1940, entre pacientes epilépticos, demonstra que a gênese da contratura seja relacionada com a introdução no mercado dos medicamentos anticonvulsivantes 3,[8][9][10][11][12] .…”

Section: Relato Do Casounclassified

See 1 more Smart Citation

Doenças de Dupuytren e de Ledderhose associadas ao uso crônico de anticonvulsivantes: relato de caso

Coral

Zanatta

Teive

et al. 1999

Arq. Neuro-Psiquiatr.

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RESUMO -Relatamos o caso de um paciente que após uso crônico de anticonvulsivantes, sem epilepsia definida, desenvolveu contraturas das aponeuroses palmar (doença de Dupuytren) e plantar (doença de Ledderhose). Discutimos as principais dessas complicações, os fatores predisponentes e sua estreita relação com o uso de anticonvulsivantes, particularmente de fenobarbital.PALAVRAS-CHAVE: doença de Dupuytren, doença de Ledderhose, anticonvulsivantes. Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants: case reportABSTRACT -We present the case of a patient that after chronic use of anticonvulsant drugs without proven epilepsy , developed Dupuytren's and Ledderhose's diseases. We discuss the most frequent predisponent factors, and their relationship with chronic use of anticonvulsants, particularly phenobarbitone.

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Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants.

Cited by 73 publications

References 7 publications

Clinical associations of Dupuytren’s disease

Clinical associations of Dupuytren’s disease

Can rock climbing lead to Dupuytren’s disease?

Doenças de Dupuytren e de Ledderhose associadas ao uso crônico de anticonvulsivantes: relato de caso

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