Dupuytren's disease. Its association with abnormal liver function in alcoholism and epilepsy

Pojer, J; Radivojević, Milan; Williams, T. Franklin

doi:10.1001/archinte.129.4.561

Cited by 40 publications

(9 citation statements)

References 26 publications

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“…Over the age of 60 the corresponding figures were 88% (male) and 50% (female). A similar high prevalence of 55% has been confirmed in a more recent investigation (Pojer et al, 1972). Somewhat lower figures were reported by Early (1962) andWalshe (1972).…”

Section: Dupytren's Contracturesupporting

confidence: 81%

“…Somewhat lower figures were reported by Early (1962) andWalshe (1972). In view of the high prevalence of D.C. among alcoholics, Pojer et al (1972) wondered whether a disturbance in liver function is common to both clinical situations (see section on liver). Although Lund (1941) found no correlation between daily dosage of luminal ingestion and the presence of D.C., he considered that this drug was a possible causative factor, especially as there was a very considerably reduced incidence of D.C. in patients on bromide therapy.…”

Section: Dupytren's Contracturementioning

confidence: 99%

“…Finally, Pojer et al (1972) have reported an association between Dupytren's contracture in epileptic patients and elevated levels of some hepatic excretory and hepatocellular enzymes, but the exact nature of this association is unclear (Lancet, 1972). Andreasen et al (1973) found raised serum aminotransferase and plasma prothrombin time in addition to the previously reported changes in alkaline phosphatase, calcium, and bilirubin in their 51 outpatient epileptics.…”

Section: Enzyme Inductionmentioning

confidence: 99%

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Chronic Antiepileptic Toxicity: A Review

Reynolds

1975

Epilepsia

272

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Section: Dupytren's Contracturesupporting

confidence: 81%

Section: Dupytren's Contracturementioning

confidence: 99%

Section: Enzyme Inductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Antiepileptic Toxicity: A Review

Reynolds

1975

Epilepsia

272

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“…Chronic alcoholic patients with cirrhosis of the liver had a prevalence of DD of 66%, and alcoholic patients without cirrhosis 27%. 23 Other studies confirmed this, [24][25][26] and the belief that alcohol was an aetiological factor became established.…”

Section: Alcoholmentioning

confidence: 76%

Clinical associations of Dupuytren’s disease

Hart

Hooper

2005

Postgraduate Medical Journal

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Dupuytren’s disease (DD) is a common progressive fibrotic condition affecting the palmar and digital fascia. Although its management is undertaken by hand surgeons, it is commonly seen by other doctors as an incidental finding. In many cases it is believed to be associated with other medical conditions, although the evidence for such associations is not always clear. This review considers the evidence behind these associations and discusses the aetiology of DD. By doing so, it is hoped that this review will permit a better understanding of the relevance of DD as a clinical sign.

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“…This is supported by the good response to steroid treatment in our patient, which was also reported by others.5 Most patients described with this syndrome had a malignancy, especially ovarian adenocarcinoma.9 This syndrome can also occur in non-malignant diseases, such as chronic alcoholism leading to cirrhosis,'0 and after the use of drugs such as phenobarbitone or isoniazid. [10][11][12][13] In malignancy the cause of the syndrome remains an enigma. Interestingly, however, mesothelial tissue seems to play a part, as it must in all patients with ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Palmar fasciitis and arthritis in a patient with an extraovarian adenocarcinoma of the coelomic epithelium.

Willemse¹,

Mulder²,

Tempel³

et al. 1991

Annals of the Rheumatic Diseases

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Case report A 54 year old white woman presented in September 1986 with increasing abdominal distension and stool frequency. Weight loss amounted to 8 kg over three months. The menses had ceased at 51 years, and she was gravida 2 para 2. On physical examination she had an asthenic habitus and cachectic, height 162 cm, weight 56 kg, with diffusely pigmented skin, more apparent on pressure points-for example, over the knuckles, elbows, and knees. The right knee and proximal interphalangeal joint of the third right finger were swollen and painful. There was no history of previous arthritis or Raynaud's disease. A physical examination showed massive ascites, and after abdominal paracentesis a mobile mass of about 12 cm was felt in the left upper abdomen. Gynaecological examination showed a normal uterus, the adnexa could not be properly felt. Laboratory investigations showed raised lactic dehydrogenase (785 (normal <245 U/1)) and raised tumour marker CA 125 (1478 (normal <36 U/1)), but a normal carcinoembryonic antigen and haemoglobin concentration. Antinuclear factor, antiperinuclear factor, and IgM rheumatoid factor were negative; the C reactive protein and erythrocyte sedimentation rate were all normal. There was no eosinophilia. An abdominal ultrasound showed a large amount of ascites and a massively infiltrated omentum, but a normal liver, no signs of ureteral obstruction, and normal ovaries and uterus. Gastroscopy and a barium enema were also normal. An exploratory laparotomy was then performed. The omentum was massively infiltrated with tumour, and throughout the whole abdominal cavity nodules up to 2 mm were present. No tumour was felt in pancreas, gall bladder, stomach, large and small bowel. The uterus appeared normal, but on the surface of the otherwise apparently normal ovaries there were also numerous superficial tumour nodules. Microscopical examination of the intraperitoneal implants showed an undifferentiated serous cystadenocarcinoma, but in both ovaries only superficial tumour implants were found. Additional immunofluorescence testing of this tissue was negative for carcinoembryonic antigen and positive for epithelial membrane antigen, concordant with an adenocarcinoma, probably of primary coelomic origin.About three weeks after the operation she received six monthly courses of combination chemotherapy with intravenous carboplatin 300 mg/m2 and cyclophosphamide 750 mg/M2. The ascites disappeared and ultrasound scan and tumour marker CA 125 indicated a partial remission. During cytostatic treatment she complained of increasing pain in all finger joints and in the right knee, which became swollen and warm. Despite treatment with oral naproxen 250 mg four times a day she developed progressive swelling of the metacarpophalangeal and interphalangeal joints of both hands, and of the elbows and complained of stiff shoulders. A bone scan showed increased activity in the small and large joints (fig 1). A flexion contracture of the intrinsic hand muscles and palmar fascia

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Dupuytren's disease. Its association with abnormal liver function in alcoholism and epilepsy

Cited by 40 publications

References 26 publications

Chronic Antiepileptic Toxicity: A Review

Chronic Antiepileptic Toxicity: A Review

Clinical associations of Dupuytren’s disease

Palmar fasciitis and arthritis in a patient with an extraovarian adenocarcinoma of the coelomic epithelium.

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