Durability of Artificial Urinary Sphincter With Prior Radiation Therapy

Functional outcomes of artificial urinary sphincter implantation with distal bulbar double cuff in men with and without a history of external beam radiotherapy: an analysis of a prospective database

“…This is further supported by data (94 patients, 31 irradiated) published by Jhavar et al. in 2017 with a median FU of 62 months, which showed no statistical significance with respect to AUS revision (26% vs 20%), erosion (13% vs 20%), infection (7% vs 7%), and removal rates (23% vs 10%), between both cohorts.…”

“…Sathianathen et al [7] concluded from a prospective database (77 patients, 29 irradiated) evaluating the outcomes of AUS in irradiated men with SUI, that the rates of continence (86.2% vs 87.5%), the incidence of infection (3.4% vs 0%), erosion (3.4% vs 2.0%), and revision surgery (10.3% vs 12.5%), did not differ between irradiated and non-irradiated patients. This is further supported by data (94 patients, 31 irradiated) published by Jhavar et al [17] in 2017 with a median FU of 62 months, which showed no statistical significance with respect to AUS revision (26% vs 20%), erosion (13% vs 20%), infection (7% vs 7%), and removal rates (23% vs 10%), between both cohorts.…”

Impact of radiation therapy on artificial urinary sphincter implantation in male patients: A multicenter study

“…Radiation causes tissue alteration through local fibrosis and endarteritis. This results in poor local vascularization and reduced ability to respond to infection and healing 7,9,10,14,14,15 …”

Radiotherapy is associated with reduced continence outcomes following implantation of the artificial urinary sphincter in men with post-radical prostatectomy incontinence

“…While Jhavar et al . concluded that prior radiation did not alter AUS postoperative outcomes,[ 24 ] Suardi et al . reported that at 1 and 3 years after adjuvant radiotherapy, urinary continence recovery was 51% and 59% as opposed to 81% and 87% for those not receiving adjuvant radiotherapy.…”

“…[ 25 ] This is confirmed in the reports of higher rates of persistent urinary incontinence post-AUS implantation in those men treated with adjuvant and neoadjuvant radiotherapy, with rates ranging from 5% to 48%. [ 19 23 24 25 26 27 28 29 30 31 32 33 34 ]…”