Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. A follow-up report at one year.

O’Driscoll, Shawn W.; Keeley, F. W.; Salter, Robert B.

doi:10.2106/00004623-198870040-00017

Cited by 531 publications

(353 citation statements)

References 0 publications

Supporting

Mentioning

324

Contrasting

Unclassified

Order By: Relevance

“…After macroscopic examination, 5 distal femora in each group were dissected at weeks 4, 8, and 16 and embedded in paraffin. Specimens were stained with Safranin O-fast green, and the histologic grading scale described by O'Driscoll et al (37) was used to evaluate the quality of the repaired tissue.…”

Section: Methodsmentioning

confidence: 99%

The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair

Matsumoto¹,

Kubo²,

Meszaros³

et al. 2008

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair

Matsumoto¹,

Kubo²,

Meszaros³

et al. 2008

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…Toluidine blue 31 and Levai-Laczko 32,33 stains were used. The slides were graded independently by three reviewers using the ICRS Visual Histological Scale, 34 the O'Driscoll Scale 35 and the semiquantitative Siebert score. 36 High-resolution micro-computed tomography ( CT) scans were made of all triphasic constructs (La Theta TM LCT-100, Aloka, Inc., Tokyo, Japan).…”

Section: Surgical Techniquesmentioning

confidence: 99%

“…The slides were then treated with toluidine blue 31 and Levai-Laczko 32,33 stains and finally graded independently by three reviewers including a specialist orthopedic surgeon and a musculoskeletal pathologist using the ICRS Visual Histological Visual Scale (Table A3), 34 the O'Driscoll Scale (Table A4) 35 and the semiquantitative Siebert score (Table A5) …”

Section: Histological Analysismentioning

confidence: 99%

A novel MSC‐seeded triphasic construct for the repair of osteochondral defects

Marquaß

Somerson

Hepp

et al. 2010

Journal Orthopaedic Research

View full text Add to dashboard Cite

Mesenchymal stem cells (MSC) are increasingly replacing chondrocytes in tissue engineering based research for treatment of osteochondral defects. The aim of this work was to determine whether repair of critical-size chronic osteochondral defects in an ovine model using MSC-seeded triphasic constructs would show results comparable to osteochondral autografting (OATS). Triphasic implants were engineered using a beta-tricalcium phosphate osseous phase, an intermediate activated plasma phase, and a collagen I hydrogel chondral phase. Autologous MSCs were used to seed the implants, with chondrogenic predifferentiation of the cells used in the cartilage phase. Osteochondral defects of 4.0 mm diameter were created bilaterally in ovine knees (n = 10). Six weeks later, half of the lesions were treated with OATS and half with triphasic constructs. The knees were dissected at 6 or 12 months. With the chosen study design we were not able to demonstrate significant differences between the histological scores of both groups. Subcategory analysis of O'Driscoll scores showed superior cartilage bonding in the 6-month triphasic group compared to the autograft group. The 12-month autograft group showed superior cartilage matrix morphology compared to the 12-month triphasic group. Macroscopic and biomechanical analysis showed no significant differences at 12 months. Autologous MSC-seeded triphasic implants showed comparable repair quality to osteochondral autografts in terms of histology and biomechanical testing.

show abstract

“…Blocks were decalcified in saturated EDTA, embedded in paraffin, and 8 mm sections were stained with Masson’s trichrome, hematoxylin and eosin, and Safranin-O, along with immunostaining for types I (C2456, Sigma, St. Louis, MO) and II (II-II6B3; DSHB, Iowa City, IA) collagen. Sections were graded by three blinded readers according to a semiquantitative scale adapted from two schemes to incorporate features of integration or “bonding,” total collagen, bone–cartilage architecture representing “structure” (from Odriscoll et al 38 ) or “subchondral bone” (from the ICRS Visual Histological Assessment 39 ), proteoglycan staining, and types I and II collagen staining (adapted from Matrix category of ICRS to separate scoring for each collagen). Here, as for MRI and gross grading scales, two scales were combined to obtain the maximum information on all features for biomaterial performance.…”

Section: Methodsmentioning

confidence: 99%

In SituCrosslinking Elastin-Like Polypeptide Gels for Application to Articular Cartilage Repair in a Goat Osteochondral Defect Model^*

Nettles¹,

Kitaoka²,

Hanson³

et al. 2008

Tissue Engineering Part A

View full text Add to dashboard Cite

The objective of this study was to evaluate an injectable, in situ crosslinkable elastin-like polypeptide (ELP) gel for application to cartilage matrix repair in critically sized defects in goat knees. One cylindrical, osteochondral defect in each of seven animals was filled with an aqueous solution of ELP and a biocompatible, chemical crosslinker, while the contralateral defect remained unfilled and served as an internal control. Joints were sacrificed at 3 (n = 3) or 6 (n = 4) months for MRI, histological, and gross evaluation of features of biomaterial performance, including integration, cellular infiltration, surrounding matrix quality, and new matrix in the defect. At 3 months, ELP-filled defects scored significantly higher for integration by histological and gross grading compared to unfilled defects. ELP did not impede cell infiltration but appeared to be partly degraded. At 6 months, new matrix in unfilled defects outpaced that in ELP-filled defects and scored significantly better for MRI evidence of adverse changes, as well as integration and proteoglycan-containing matrix via gross and histological grading. The ELP-crosslinker solution was easily delivered and formed stable, well-integrated gels that supported cell infiltration and matrix synthesis; however, rapid degradation suggests that ELP formulation modifications should be optimized for longer-term benefits in cartilage repair applications.

show abstract

Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. A follow-up report at one year.

Cited by 531 publications

References 0 publications

The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair

The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair

A novel MSC‐seeded triphasic construct for the repair of osteochondral defects

In SituCrosslinking Elastin-Like Polypeptide Gels for Application to Articular Cartilage Repair in a Goat Osteochondral Defect Model^*

Contact Info

Product

Resources

About

Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. A follow-up report at one year.

Cited by 531 publications

References 0 publications

The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair

The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair

A novel MSC‐seeded triphasic construct for the repair of osteochondral defects

In SituCrosslinking Elastin-Like Polypeptide Gels for Application to Articular Cartilage Repair in a Goat Osteochondral Defect Model*

Contact Info

Product

Resources

About

In SituCrosslinking Elastin-Like Polypeptide Gels for Application to Articular Cartilage Repair in a Goat Osteochondral Defect Model^*