The research investigated the impact of cowbone ash blended cement concrete (CBABC) on compressive strength, considering various mix ratios and curing periods. The study involved several phases: production of cowbone ash (CBA) from waste cowbones, characterization of CBA's physical and chemical properties, and formulation of CBABC mixes with 0%, 5%, and 10% CBA as partial replacements of cement. Concrete samples were prepared at ratios of 1:2:4 and 1:3:6 and cured for 7, 14, and 28 days. Cubic CBAC specimens sized 100mm by 100mm by 100mm underwent testing for compressive strength under both aggressive and non-aggressive conditions after 7, 14 and 28-days curing period. Analysis of oxide composition revealed a high calcium oxide content in CBA, constituting 68.34% by weight. With increasing CBA proportion, CBAC mixes showed enhanced workability. Under water curing at 28 days curing conditions, CBAC concrete exhibited average compressive strengths of 12.47 N/mm², 26.34 N/mm² and 20.34 N/mm² for 0%, 5% and 10% CBA content, respectively. Upon exposure to aggressive conditions, both conventional concrete (0% CBA) and CBABC concrete experienced decreased compressive strength. Notably, the CBABC mix with 5% CBA displayed greater resistance to aggressive conditions compared to other mixes. In conclusion, CBABC with 5% CBA replacement demonstrates potential for application in aggressive environments, particularly in Sodium Sulphate (Na2SO4), offering a durable alternative to conventional Grade C25 concrete mixes.