Durable palliation of breast cancer chest wall recurrence with radiation therapy, hyperthermia, and chemotherapy

Zagar, Timothy M.; Higgins, Kristin; Miles, Edward F.; Vujašković, Željko; Dewhirst, Mark W.; Clough, Robert; Prosnitz, Leonard R.; Jones, Ellen L.

doi:10.1016/j.radonc.2010.10.020

Cited by 39 publications

(18 citation statements)

References 36 publications

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“…However, there was no difference in survival between the two treatment arms. Recent studies have analysed the combination of radiotherapy, hyperthermia and concurrent chemotherapy in this patient population [74].…”

Section: Specific Sites Of Metastasesmentioning

confidence: 99%

ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2)

Cardoso¹,

et al. 2014

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Section: Specific Sites Of Metastasesmentioning

confidence: 99%

ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2)

Cardoso¹,

et al. 2014

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“…These patients were heavily pretreated with prior radiotherapy (85%) and systemic therapy (89%). Analyzing patients by response, those achieving a complete response (80%) had a median overall survival of 23 months, while partial responders (20%) had a median overall survival of 5.4 months (p = 0.01) [42]. …”

Section: Hyperthermia In Breast Cancer Recurrencesmentioning

confidence: 99%

Role of Hyperthermia in Breast Cancer Locoregional Recurrence: A Review

Maluta¹,

Kolff

2015

Breast Care

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In patients with locoregional recurrences of breast cancer not suitable for resection, subsequent local control is difficult to maintain in previously irradiated areas when reirradiation alone or reirradiation with chemotherapy is used. Due to the limited number of treatment options there is a high risk of subsequent failure and uncontrollable local disease. In this group of patients, local hyperthermia combined with radiotherapy increases the clinical response and local control, adding limited acute and late toxicity, as has been shown in randomized trials. Hyperthermia is an artificial elevation of tissue temperature (range 40-44°C for 30-60 min). If hyperthermia is applied shortly before or after radiation, the effect of radiation is enhanced by influencing intratumoral hypoxia and by inhibiting sublethal damage repair in the tumor. Moreover, hyperthermia combined with radiation reduces the total dose of radiation needed compared to radiation alone, of which a higher dose is needed to obtain the same effect. Few data are available on the combination of radiotherapy and hyperthermia with chemotherapy, although the results of trimodality treatment consisting of reirradiation and hyperthermia together with liposomal doxorubicin are promising. Therefore, this literature review was performed to provide more comprehensive data on the mechanism and use of hyperthermia in locoregional recurrence of breast cancer.

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“…Thus, only few series using EBRT alone [53,54,55] or in combination with hyperthermia for re-irradiation of the chest wall have been published so far [56,57,58,59,60,61]. Additionally, simultaneous radiochemotherapy as a further treatment option has been investigated in a limited number of trials [62,63,64]. …”

Section: Therapy Of Isolated Locoregional Recurrences After Mastectommentioning

confidence: 99%

Current Treatment of Isolated Locoregional Breast Cancer Recurrences

et al. 2015

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Patients with isolated locoregional breast cancer recurrences should be treated with curative intent. Mastectomy is regarded as the standard of care for patients with ipsilateral breast tumor recurrence. In a selected group of patients, partial breast irradiation after second breast-conserving surgery is a viable alternative to mastectomy. If a second breast conservation is performed, additional irradiation should be mandatory, especially in patients who had not been irradiated previously. In case of re-irradiation, the largest experience exists for multi-catheter brachytherapy. Prospective clinical trials are needed to clearly define selection criteria, long-term local control, and toxicity. In patients with resectable locoregional breast cancer recurrences after mastectomy, multi-modal therapy comprising complete resection, radiation therapy in previously unirradiated patients, and systemic therapy results in 5-year disease-free and overall survival rates of 69% and 88%, respectively. In radiation-naive patients with unresectable, isolated locoregional recurrences, radiation therapy is mandatory. In selected patients with previous irradiations and unresectable locoregional recurrences, a second irradiation as part of an individual treatment concept can be applied. The increased risk of severe toxicity should always be weighed up against the potential clinical benefit. A combination therapy with hyperthermia can further improve the treatment results.

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Durable palliation of breast cancer chest wall recurrence with radiation therapy, hyperthermia, and chemotherapy

Cited by 39 publications

References 36 publications

ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2)

ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2)

Role of Hyperthermia in Breast Cancer Locoregional Recurrence: A Review

Current Treatment of Isolated Locoregional Breast Cancer Recurrences

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