Duración del tratamiento antibiótico en la infección intraabdominal

Maseda, Emilio; Gilsanz, F.

doi:10.1016/s0213-005x(10)70030-6

Cited by 4 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that prolonged usage of antimicrobials does not improve outcomes but instead is associated with the emergence of resistant pathogens, healthcare-associated infections, antimicrobial-related cost, and adverse effects [7,8]. Given the aforementioned risks of prolonged antimicrobial therapy, current guidelines suggest shorter treatment duration and discontinuation of antimicrobials once inflammatory markers and other signs of infection resolve [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Use of Procalcitonin to Guide Discontinuation of Antimicrobial Therapy in Patients with Persistent Intra-Abdominal Collections: A Case Series

Gabriel

Pate

Franco‐Paredes

et al. 2020

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

Objective. Limited evidence exists for the use of procalcitonin (PCT) to guide the duration of antimicrobial therapy in patients with intra-abdominal abscesses (IAA). In this case series, we describe clinical presentations and outcomes using PCT to guide cessation of antimicrobial therapy in patients with persistent IAA who exhibited clinical improvement. Methods. A retrospective analysis of patients with IAA who had PCT levels available to review was performed in a tertiary academic teaching institution in the United States between 2017 and 2018. Demographics, clinical characteristics, and outcomes were obtained from the medical records. Patients were followed up for a minimum of 180 days after completion of antimicrobial therapy to determine if evidence of recurrence or mortality was present. Results. We identified four patients with IAA. They underwent early drainage of the source of infection and received empiric antimicrobial therapy according to individual risk factors and clinical scenarios. Antimicrobials were discontinued after clinical and radiographic improvement and evidence of normal PCT levels, regardless of the persistence of fluid collections. No evidence of recurrence or mortality was observed during the follow-up period. Conclusions. We found PCT to be a useful aid in the medical decision-making process to safely discontinue antimicrobial therapy in a series of patients with persistent intra-abdominal collections despite early drainage and appropriate course of antimicrobial therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Use of Procalcitonin to Guide Discontinuation of Antimicrobial Therapy in Patients with Persistent Intra-Abdominal Collections: A Case Series

Gabriel

Pate

Franco‐Paredes

et al. 2020

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

show abstract

Procalcitonin-guided therapy may reduce length of antibiotic treatment in intensive care unit patients with secondary peritonitis: A multicenter retrospective study

Maseda

Suárez-de-la-Rica

Anillo

et al. 2015

Journal of Critical Care

View full text Add to dashboard Cite

Basis for selecting optimum antibiotic regimens for secondary peritonitis

Maseda

Giménez²,

Gilsanz

et al. 2015

Expert Review of Anti-infective Therapy

View full text Add to dashboard Cite

Adequate management of severely ill patients with secondary peritonitis requires supportive therapy of organ dysfunction, source control of infection and antimicrobial therapy. Since secondary peritonitis is polymicrobial, appropriate empiric therapy requires combination therapy in order to achieve the needed coverage for both common and more unusual organisms. This article reviews etiological agents, resistance mechanisms and their prevalence, how and when to cover them and guidelines for treatment in the literature. Local surveillances are the basis for the selection of compounds in antibiotic regimens, which should be further adapted to the increasing number of patients with risk factors for resistance (clinical setting, comorbidities, previous antibiotic treatments, previous colonization, severity…). Inadequate antimicrobial regimens are strongly associated with unfavorable outcomes. Awareness of resistance epidemiology and of clinical consequences of inadequate therapy against resistant bacteria is crucial for clinicians treating secondary peritonitis, with delicate balance between optimization of empirical therapy (improving outcomes) and antimicrobial overuse (increasing resistance emergence).

show abstract

Duración del tratamiento antibiótico en la infección intraabdominal

Cited by 4 publications

References 32 publications

Use of Procalcitonin to Guide Discontinuation of Antimicrobial Therapy in Patients with Persistent Intra-Abdominal Collections: A Case Series

Use of Procalcitonin to Guide Discontinuation of Antimicrobial Therapy in Patients with Persistent Intra-Abdominal Collections: A Case Series

Procalcitonin-guided therapy may reduce length of antibiotic treatment in intensive care unit patients with secondary peritonitis: A multicenter retrospective study

Basis for selecting optimum antibiotic regimens for secondary peritonitis

Contact Info

Product

Resources

About