Dural-Based Frontal Lobe Hemangioblastoma

Lacerda, Rafael Antônio Vicente; Júnior, Antônio Gilvan Teixeira; Filho, Euler Nicolau Sauaia; Filho, Leonardo José Monteiro de Macêdo; Antônio, André Soldati; Cabral, Jan; Júnior, Francisco Ramos; Júnior, José Telmo Valença

doi:10.1016/j.wneu.2019.05.175

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…Magnetic resonance imaging (MRI) is the “gold standard” for differential diagnosis. On T1-weighted enhancement imaging, the tumor shows uniform nodular enhancement, and its cystic portion shows high signal on T2-weighted imaging and no enhancement on contrast-enhanced imaging ( 20 , 21 ). 4) Angioleiomyoma are mesenchymal tumors consisting of well-differentiated smooth muscle cells and blood vessels with thick walls.…”

Section: Discussionmentioning

confidence: 99%

Pontine Myopericytoma: Case Report and Literature Review

et al. 2022

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Myopericytoma (MPC) is a benign soft tissue tumor that develops from perivascular myoid cells and is part of the perivascular tumor group. MPC most commonly occurs in the subcutaneous soft tissues of the extremities, while intracranial MPC is remarkably rare. Herein, we report the case of a 45-year-old woman with myopericytoma who had a 2-week history of recurrent dizziness. Magnetic resonance imaging (MRI) revealed an irregular mass in the pons, with nodular enhancement of the mass on contrast-enhanced scans. The mass was considered a vascular lesion and was highly suspected to be a hemangioblastoma, prompting surgical intervention for the patient. The postoperative pathological report corrected the initial diagnosis, hemangioblastoma, to MPC. Intracranial MPC is extremely rare and there are no detailed imaging sources for this condition; furthermore, MPC occurrence in the pons has not been reported previously. This report presents the etiological characteristics intracranial MPC as visualized through MRI data alongside a comparative discussion on other reported diagnoses that resemble MPC. The case findings will provide a more widespread understanding for radiologists regarding the differential diagnosis of intracranial blood-rich supply lesions.

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Section: Discussionmentioning

confidence: 99%

Pontine Myopericytoma: Case Report and Literature Review

et al. 2022

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“…In 2019, Vicente et al . [ 45 ] described another case, a 64-year-old woman with a left frontal parasagittal supratentorial hemangioblastoma adjacent to the dura. That year, Bian et al .…”

Section: Discussionmentioning

confidence: 99%

Sporadic supratentorial hemangioblastoma with meningeal affection: A case report and literature review

Ortega

Claramonte

Martín

et al. 2021

Surgical Neurology International

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Background: Hemangioblastomas are vascular tumors, of benign behavior, that originate in the central nervous system. Supratentorial hemangioblastomas are extremely rare and are generally associated with Von Hippel-Lindau disease (VHL). The involvement of structures by contiguity, such as blood vessels or meninges, is something exceptional. There are few references in the literature of supratentorial hemangioblastomas with meningeal involvement and most of them are described in reports or small case series. Methods: We performed a systematic review of the literature to observe the characteristics of patients with supratentorial hemangioblastomas with meningeal involvement. In addition, we present the case of a 43-year-old male patient with a sporadic supratentorial hemangioblastoma with both, meningeal and vascular involvement that recurred years after treatment. Results: The patients presented supratentorial tumors with meningeal involvement, we had a 1.2:1 ratio male-female distribution. The mean age was 50 years. Most tumors were located in the cerebral hemispheres, the lobe affected most frequently was the frontal lobe. About 67% of the cases were sporadic and only 21% were related to VHL disease. There were three cases of recurrence after surgery. Conclusion: Supratentorial hemangioblastomas are extremely rare lesions. It is rare for supratentorial hemangioblastomas to invade adjacent structures such as blood vessels or meninges, however, when this happens, it is recommended a preoperative vascular imaging study, especially in parasagittal hemangioblastomas where superior longitudinal sinus may be involved. In these cases, en bloc surgical resection is difficult and the probability of recurrence is higher. Although clinical trials and studies with a greater casuistry are necessary to establish guidelines for the management of supratentorial hemangioblastomas, nowadays, contribution of new cases is useful for understanding this pathology.

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“…The main differential diagnosis of hemangioblastoma includes angiomatous meningioma, vascular malformation and hemangioma, juvenile pilocytic astrocytoma, and metastatic renal cell carcinoma. 10 In addition to the combination of tumor location, radiological data, and medical history, immunohistochemical detection is also very useful. The stromal cells of hemangioblastoma usually express NSE (5/5 in this group), S-100 (2/2 in this group), CD56 (2/2 in this group), EGFR (6/6 in this group), vimentin (5/5 in this group), inhibin-α (0/3 in this group), and D2-40 (0/1 in this group), but do not express GFAP, CD10, EMA, CgA, or Syn.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Hemangioblastoma Without Von Hippel-Lindau Syndrome: A Report of 6 Cases

et al. 2020

Int J Surg Pathol

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Background. Hemangioblastoma occurs mainly in the cerebellum and rarely in the cerebrum. Objective. The present study aimed to analyze the clinical manifestations and radiological and pathological features of cerebral hemangioblastoma, and to improve the recognition of this tumor and avoid misdiagnosis. Methods. The characteristics of 6 patients with cerebral hemangioblastoma were analyzed, and a retrospective review of cerebral hemangioblastoma reported in the literature was performed. Results. All 6 patients were female, aged from 22 to 70 years (55 years on average), and all cases were wild-type sporadic, in which 4 cases occurred in the frontal lobe and 2 cases occurred in the parietal lobe. Imaging revealed a solid tumor in 4 cases, a cystic tumor in 1 case, and a mixed tumor in 1 case. Microscopically, the morphology and immunophenotype of tumor cells were not different from those of classical hemangioblastoma. All 6 patients survived tumor free during the follow-up period. Conclusions. Cerebral hemangioblastoma often simulates the imaging characteristics of meningioma or glioma. Enough attention should be paid to differential diagnosis before the operation, and exact diagnosis relies on the pathological examination.

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Dural-Based Frontal Lobe Hemangioblastoma

Cited by 6 publications

References 34 publications

Pontine Myopericytoma: Case Report and Literature Review

Pontine Myopericytoma: Case Report and Literature Review

Sporadic supratentorial hemangioblastoma with meningeal affection: A case report and literature review

Cerebral Hemangioblastoma Without Von Hippel-Lindau Syndrome: A Report of 6 Cases

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