Duramycin-porphyrin conjugates for targeting of tumour cells using photodynamic therapy

Broughton, Laura J.; Giuntini, Francesca; Savoie, Huguette; Bryden, Francesca; Boyle, Ross W.; Maraveyas, Anthony; Madden, Leigh A.

doi:10.1016/j.jphotobiol.2016.09.001

Cited by 14 publications

(6 citation statements)

References 80 publications

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“…porfimer sodium, verteporfin, temoporfin). [17][18][19][20][21] The addition of heavy atoms, usually transition metals, 22 the encapsulation of the PS into nanoparticles 23 and the use of supramolecular structures 24 are among the strategies employed to design new tetrapyrrolic PS for PDT. Furthermore, conjugation to bioactive molecules, such as antibodies, 25 significantly increases the selectivity of the PDT agent towards the targeted cancerous cells.…”

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confidence: 99%

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Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Savoie

Figliola

Marchal

et al. 2018

Photochem Photobiol Sci

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The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER- and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.

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confidence: 99%

“…Furthermore, conjugation to bioactive molecules, such as antibodies, 25 significantly increases the selectivity of the PDT agent towards the targeted cancerous cells. 18,26,27 However, cyclic tetrapyrrolic compounds are often Photo-induced anticancer activity and singlet oxygen production of prodigiosenes…”

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confidence: 99%

Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Savoie

Figliola

Marchal

et al. 2018

Photochem Photobiol Sci

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“…Several porphyrins are now approved for a variety of diseases, including cancers [149,150,151] and age-related macular degeneration [152,153].…”

Section: Other Applications Of Porphyrinsmentioning

confidence: 99%

Application of Porphyrins in Antibacterial Photodynamic Therapy

2019

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Antibiotics are commonly used to control, treat, or prevent bacterial infections, however bacterial resistance to all known classes of traditional antibiotics has greatly increased in the past years especially in hospitals rendering certain therapies ineffective. To limit this emerging public health problem, there is a need to develop non-incursive, non-toxic, and new antimicrobial techniques that act more effectively and quicker than the current antibiotics. One of these effective techniques is antibacterial photodynamic therapy (aPDT). This review focuses on the application of porphyrins in the photo-inactivation of bacteria. Mechanisms of bacterial resistance and some of the current ‘greener’ methods of synthesis of meso-phenyl porphyrins are discussed. In addition, significance and limitations of aPDT are also discussed. Furthermore, we also elaborate on the current clinical applications and the future perspectives and directions of this non-antibiotic therapeutic strategy in combating infectious diseases.

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“…For an excellent review of organ-specific PDT clinical trials, see van Straten et al 37 Generally, targeting moieties for tetrapyrroles have included small molecules such as folic acid, 38 sterols, 39 and alkylphosphocholine, 40,41 peptides, 42,43 proteins, 44 nanoparticles, 45−47 gels, 48,49 antibody fragments, and antibody species. 50 Antibodies are Y-shaped macromolecular proteins, produced naturally by B-cells in blood upon activation of the immune system.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Generally, targeting moieties for tetrapyrroles have included small molecules such as folic acid, sterols, and alkylphosphocholine, , peptides, , proteins, nanoparticles, − gels, , antibody fragments, and antibody species . Antibodies are Y-shaped macromolecular proteins, produced naturally by B-cells in blood upon activation of the immune system. , ADCs represents an opportunity to personalize the treatment of cancers by targeting of specific antigens which can be overexpressed by certain cancer cells .…”

Section: Introductionmentioning

confidence: 99%

Photosensitizer Antibody–Drug Conjugates: Past, Present, and Future

Sandland

Boyle

2019

Bioconjugate Chem.

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This Review aims to highlight key aspects of tetrapyrrole-based antibody–drug conjugates (ADCs) and significant developments in the field since 2010. Many new conjugation methods have been developed and employed in the past decade, and associated with this, there has been a rising interest in theranostic conjugates. We have investigated the physicochemical properties that tetrapyrroles need to possess in order to be viable photosensitizers for conjugation to antibodies. Differences in conjugation strategies are discussed, and structure–activity relationships of tetrapyrrole–antibody conjugates are reported, where available. As the elegance of bioconjugation techniques has increased, it has paved the way for exceptionally phototoxic, yet highly selective, tetrapyrrole–antibody conjugates, with photocytotoxicities in the nanomolar range, to be synthesized and biologically evaluated.

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Duramycin-porphyrin conjugates for targeting of tumour cells using photodynamic therapy

Abstract: Duramycin, through binding with phosphatidylethanolamine (PE),

Cited by 14 publications

References 80 publications

Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Application of Porphyrins in Antibacterial Photodynamic Therapy

Photosensitizer Antibody–Drug Conjugates: Past, Present, and Future

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