Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study

Humes, David J.; Abdul‐Sultan, Alyshah; Walker, Alex J; Ludvigsson, Jonas F.; West, Joe

doi:10.1007/s10029-017-1716-6

Cited by 13 publications

(8 citation statements)

References 17 publications

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“…Even worse, with the day case surgery becoming increasingly common in inguinal hernia repair in China, patients' length of hospital stay decreases to 24 to 48 h, which makes it difficult to make the comprehensive evaluation on patients' risk for postsurgical VTE. Moreover, studies have found that the peak risk of VTE following inguinal hernia repair occurred in the first 2 weeks (19). A significant number of patients are not protected with anticoagulants, and can develop VTE after discharge from the hospital (20).…”

Section: Discussionmentioning

confidence: 99%

Rationale and design of a prospective, multicenter, randomized controlled trial of postoperative venous thromboembolism prophylaxis in Chinese adult patients with inguinal hernia (CHAT-3 trial)

Cao¹,

Zhang²,

et al. 2021

Ann Palliat Med

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Background: Venous thromboembolism (VTE) is one of the most common causes of preventable harm for patients in hospitals. Nearly half of all VTE events was estimated to occur after surgical procedure. The Caprini risk score is the most extensively used risk assessment tool in predicting postoperative VTE, which is too complicate for surgeons to use properly in their clinical practice.Methods: The CHAT-3 trial will be a prospective, multicenter, randomized, parallel-group trial, which is designed to identify patients at moderate or high risk of VTE after inguinal hernia surgery using the previously established three-factor model, and to use low molecular weight heparin (LMWH) for VTE prevention, in comparison to the current routine assessment and practice used in those patients. Totally, 1,008 patients planned to undergo inguinal hernia surgery will be enrolled, with cluster randomization at 1:1 ratio into intervention arm and control arm. The primary outcomes are the accordance of perioperative VTE prophylaxis based on current guidelines and the rate of pharmacological prophylaxis for VTE. The secondary outcomes are the occurrences of perioperative VTE, major bleeding, mortality of patients after inguinal hernia surgery, and trend of D-dimer during the follow-up period.Discussion: This study will create evidence that whether the administration based on a simple model is of efficacy and safety for VTE prophylaxis among Chinese patients underwent inguinal hernia surgery.

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Section: Discussionmentioning

confidence: 99%

Rationale and design of a prospective, multicenter, randomized controlled trial of postoperative venous thromboembolism prophylaxis in Chinese adult patients with inguinal hernia (CHAT-3 trial)

Cao¹,

Zhang²,

et al. 2021

Ann Palliat Med

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“…There are no large-scale studies in China to confirm the number of deaths caused by VTE after surgery. According to available statistics, VTE causes more than 296,000 deaths each year in the United States 15 , and the annual number of deaths secondary to VTE in the United Kingdom is more than 5 times that of breast cancer, AIDS, and traffic accidents 16 . Surgery itself is an important factor in the development of VTE.…”

Section: Discussionmentioning

confidence: 99%

Current prevalence of perioperative early venous thromboembolism and risk factors in Chinese adult patients with inguinal hernia (CHAT-1)

Wang

Chen

et al. 2020

Sci Rep

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Venous thromboembolism (VTE) is an important postoperative complication. We investigated and analyzed the current inguinal hernia treatment methods and occurrence of early postoperative VTE in Chinese adults. This study involved data for patients with inguinal hernia hospitalized in 58 general hospitals in mainland China from January 1st, 2017 to December 31st, 2017. Data were retrospectively analyzed using a questionnaire. After data inputting and cleaning, we stratified and statistically analyzed patients' data using Caprini scores to create a high-, middle-, and low-risk group. A total of 14,322 patients with inguinal hernia were admitted to the 58 participating hospitals. After data collation and cleaning, 13,886 patients (97.0%) met our inclusion and exclusion criteria. The percentages of laparoscopic surgery and open surgery were 51.2% and 48.8%, respectively. 16 VTEs occurred during the hospitalization, accounting for 0.1% of all adverse events (95% confidence interval (CI) 0.11-0.13). The incidence of VTE was 0.2% (95% CI 0.18-0.2) in the high-risk group and 0.02% (95% CI 0.01-0.03) in the middle-risk group, based on Caprini scoring, with a significant difference (p < 0.0001). No VTE occurred in the low-risk group. Only 3,250 (23.4%) patients underwent Caprini risk assessment regarding treatment, with 13.2% receiving any prevention and only 1.2% receiving appropriate prevention. The treatment of inguinal hernia in Chinese adults has progressed somewhat; however, the evaluation and prevention of perioperative VTE was seriously neglected, in our study, and the incidence of postoperative VTE was underestimated postoperatively. Risk factors continue to be inadequately considered. With developments in surgical techniques and materials, satisfactory results have been achieved in the diagnosis and treatment of inguinal hernia, worldwide 1. Regarding the various aspects of the diagnosis and treatment of adult inguinal hernia, the HerniaSurge Group released the latest version of adult inguinal hernia management guidelines in 2018 2. Along with the guidelines from several other international hernia associations, and other associations, the HerniaSurge Group guidelines discuss the problems related to the diagnosis and treatment of inguinal hernia, in different perspectives, among which, cited references included studies performed by Chinese

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“…Adult male patients who had no previous history of a venous thromboembolism were studied after their initial surgical repair of inguinal hernia. 13,16 Fifty-three (0.18%) of 28 782 men who had surgical repair of inguinal hernia developed venous thromboembolism, within 90 days postoperatively. The risk was highest within 30 days of surgery.…”

Section: Discussionmentioning

confidence: 99%

Complicated, Complete, Indirect, Irreducible Right Inguinoscrotal Hernia

Brumbaugh

Drake

Babij

2020

Journal of Diagnostic Medical Sonography

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Inguinal hernias are the most common of all hernias. A complicated hernia is irreducible, and the contents are obstructed or strangulated. Sonography is considered the imaging modality of choice for the diagnosis of abnormalities of the inguinal area. This case study is about a patient with an inguinal hernia that had not been repaired and progressed into a life-threatening, complicated inguinoscrotal hernia. The patient’s complaints and clinical findings required sonographic examinations of the abdomen, pelvis, inguinal canal, and scrotum. Sonographic findings were corroborated by findings with computed tomography (CT). After the compromised intestine was resected and the hernia was repaired, the patient developed a deep vein thrombosis (DVT), identified sonographically. The patient was successfully treated and discharged.

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Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study

Cited by 13 publications

References 17 publications

Rationale and design of a prospective, multicenter, randomized controlled trial of postoperative venous thromboembolism prophylaxis in Chinese adult patients with inguinal hernia (CHAT-3 trial)

Rationale and design of a prospective, multicenter, randomized controlled trial of postoperative venous thromboembolism prophylaxis in Chinese adult patients with inguinal hernia (CHAT-3 trial)

Current prevalence of perioperative early venous thromboembolism and risk factors in Chinese adult patients with inguinal hernia (CHAT-1)

Complicated, Complete, Indirect, Irreducible Right Inguinoscrotal Hernia

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