Duration and morbidity of chronic immune thrombocytopenic purpura in children: five‐year follow‐up of a Nordic cohort

Abstract

In a Nordic cohort of children with chronic ITP, one half had recovered 5 years after diagnosis, more than half never required hospitalization and <10% experienced serious bleeding episodes, always with a platelet count <20 × 10(9) /L. Aggressive management can be restricted to the minority of children with continuing severe thrombocytopenia and frequent, clinically significant bleeding events.

Clinical outcome of childhood chronic immune thrombocytopenia: A 38‐year experience from a single tertiary center in Thailand

“…Information on long‐term outcomes and clinically predictive factors for disease remission of chronic ITP in children is scarce and what studies have been done have reported varying results . There are no definite clinical parameters for predicting clinical outcome or remission, since all studies, including ours, had limitations due to the retrospective study design .…”

“…Information on long-term outcomes and clinically predictive factors for disease remission of chronic ITP in children is scarce and what studies have been done have reported varying results. 9,11,12 There are no definite clinical parameters for predicting clinical outcome or remission, since all studies, including ours, had limitations due to the retrospective study design. 10 However, our study was long-term (over 38 years) and included 113 children with chronic ITP who were followed up for a median duration of almost 6 years (range 0.5-24 years) and had a median time to remission of 7.1 years (95% CI: 4.8-11.0).…”

“…Remission rates at various times have been reported in other series: 30–60% at 5 years, 44% and 65% at 10 years, and 61% at 15 years . Blanchette and Price reviewed seven studies including 251 childhood chronic ITP cases conducted for varying periods of time between 1952 and 2000 and found that the overall number of cases achieving remission ranged from 10 to 63%, but patient follow‐up times and sample sizes varied considerably among the reports.…”

Treatment of Chronic Immune Thrombocytopenic Purpura with Homeopathic Dilutions of Patient Blood

“…in chronic ITP. Rosthoi et al [7] observed a spontaneous recovery within 3 months in less than 5% of the children, and within 2 years, in 35% of the children. Similarly, Coccia et al [8] report a spontaneous remission rate of 42.8% within a period of 9-90 months, and calculate a probability of spontaneous remission of 24% at 4 years and of 50% at 8 years.…”

IL‐10 polymorphisms and T‐cell subsets could affect the clinical presentation and outcome of childhood immune thrombocytopenia in Egyptian population

“…However, approximately, 20-30% of children have persistent thrombocytopenic states for more than 6-12 months, which is called chronic ITP with increasing risk of bleeding (5,6). Fortunately, 30-60% of chronic childhood ITP patients regains normal platelet count and gets spontaneous remission within 5 years from initial diagnosis (7). IL-10 is an important immunoregulatory cytokine with mainly an anti-inflammatory role in the immune system.…”