2022
DOI: 10.1007/s00213-022-06243-0
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Duration- and sex-dependent neural circuit control of voluntary physical activity

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Cited by 10 publications
(10 citation statements)
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“…To determine whether neural activity within unique DS subregions is necessary for normal fear extinction, a cocktail of the GABA A /GABA B receptor agonists Musc/Bac was injected directly into the DMS or DLS prior to fear extinction. Increasing confidence that Musc/Bac can successfully inhibit neural activity in DS subregions is the observation that the same Musc/Bac cocktail as used here inhibits neural activity in the DMS and DLS elicited by a bout of voluntary wheel running [36]. Similar to prior reports [36], neither DMS nor DLS inhibition altered general locomotor activity (Figures 3F and 3L).…”
Section: Discussionsupporting
confidence: 84%
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“…To determine whether neural activity within unique DS subregions is necessary for normal fear extinction, a cocktail of the GABA A /GABA B receptor agonists Musc/Bac was injected directly into the DMS or DLS prior to fear extinction. Increasing confidence that Musc/Bac can successfully inhibit neural activity in DS subregions is the observation that the same Musc/Bac cocktail as used here inhibits neural activity in the DMS and DLS elicited by a bout of voluntary wheel running [36]. Similar to prior reports [36], neither DMS nor DLS inhibition altered general locomotor activity (Figures 3F and 3L).…”
Section: Discussionsupporting
confidence: 84%
“…Microinjectors were left in place for 2 min after infusion to allow for diffusion. Microinjections occurred 15 min prior to fear extinction training, as this was the timepoint used in our prior studies using these drugs [32, 36]. All rats were exposed to mock infusion procedures in the infusion room once a day for 2 days prior to microinjections to habituate rats to the microinjection procedure.…”
Section: Methodsmentioning
confidence: 99%
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“…When motivation for reward is absent, the dorsal striatum emerges as the prevailing circuit with a bias toward habit formation, and with changes in relative synaptic strength arising in the DMS vs. DLS due to the DAT Val559 mutation. Emerging evidence suggests that engagement of striatal circuitry during operant learning differs by sex [ 66 ]. Intriguingly, the impacts of ADE in DAT Val559 mice also differ in a sex- and region-specific manner with DAT Val559 females displaying alterations in DA dynamics specific to the ventral striatum [ 46 ].…”
Section: Discussionmentioning
confidence: 99%
“…When motivation for reward is absent, the dorsal striatum emerges as the prevailing circuit with a bias toward habit formation, and with changes in relative synaptic strength arising in the DMS vs DLS due to the DAT Val559 mutation. Emerging evidence suggests that engagement of striatal circuitry during operant learning differs by sex[65]. Intriguingly, the impacts of ADE in DAT Val559 mice also differ in a sex- and region-specific manner with DAT Val559 females displaying alterations in DA dynamics specific to the ventral striatum[45].…”
Section: Discussionmentioning
confidence: 99%