2018
DOI: 10.1096/fasebj.2018.32.1_supplement.727.7
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Duration Dependent Effects of Intermittent Hypoxia (IH) on Adult Hippocampal Neurogenesis

Abstract: Patients with sleep apnea commonly exhibit cognitive decline and injury to the hippocampal formation. Rodents exposed to IH, a primary consequence of the condition, also show impaired hippocampal based learning and memory. While these impairments correlate with suppressed long‐term potentiation, synaptic plasticity is only one process that supports normal function in this brain structure. Adult neurogenesis is also important for maintaining normal hippocampal physiology. Although Hypoxia Inducible Factor 1a (H… Show more

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