Duration of anthelmintic efficacy of doramectin and ivermectin injectable solutions against naturally acquired nematode infections of cattle

Williams, Justin; Loyacano, A.F.; Broussard, S.D.; Coombs, D. F.; Walstrom, D. J.

doi:10.1016/s0304-4017(97)00074-5

Cited by 7 publications

(6 citation statements)

References 8 publications

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“…En la Tabla 1 puede observarse que a lo largo del tiempo ambos tratamientos fueron reduciendo la cantidad de huevos por gramo de heces. El test t de Student reveló que las diferencias existentes entre ambos tratamientos fueron estadísticamente significativas (p<0,05 Estos resultados no coinciden con un trabajo que expresa una eficacia clínica menor para la doramectina, indicando que en sus estudios los recuentos de huevos fecales comenzaron a aumentar nuevamente a partir de los días catorce a veintiocho y que su nivel alcanzó casi el inicial entre los días 28 a 42 post-tratamiento 10 .…”

Section: Resultados Y Discusiónunclassified

Efecto antihelmíntico de ivermectina y doramectina en bovinos destetados del sur paraguayo

et al. 2019

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Efecto antihelmíntico de ivermectina y doramectina en bovinos destetados del sur paraguayo Báez, M.C.; Lara, M.B.; Ortega, O.; Torres, M.W.; Bogarín, L.R. Resumen Báez, M.C.; Lara, M.B.; Ortega, O.; Torres, M.W.; Bogarín, L.R.: Efecto antihelmíntico de ivermectina y doramectina en bovinos destetados del sur paraguayo. Rev. Vet. 30: 2, XX-XX, 2019. El objetivo de la investigación fue determinar el efecto antihelmíntico de ivermectina y doramectina en bovinos desmamantes de las ciudades de Abaí y Caapucú (departamentos de Caazapá y Paraguari, Paraguay). A tal efecto se tomaron muestras de 40 bovinos con cargas parasitarias superiores a 400 huevos por gramo de heces, divididos en dos grupos de veinte animales cada uno. Un grupo fue medicado con ivermectina y el otro con doramectina, en ambos casos a dosis de 0,2 mg/kg de peso, vía subcutánea. Las dosis se repitieron 15 días después. Los análisis coprológicos (McMaster) se efectuaron a los 15, 30, 45 y 60 días. Al final, en los animales tratados con ivermectina y doramectina se constataron respectivamente niveles de 83 y 8 huevos por gramo de heces (p<0,05). Si bien ambos fármacos desencadenaron la disminución de huevos en materia fecal, el efecto de doramectina fue acentuadamente superior al de ivermectina. Palabras clave: vacunos desmamantes, parasitosis, ivermectina, doramectina. Abstract Báez, M.C.; Lara, M.B.; Ortega, O.; Torres, M.W.; Bogarín, L.R.: Antihelminthic effect of ivermectin and doramectin on weaned cattle from southern Paraguay. Rev. Vet. 30: 2, XX-XX, 2019. The objective of the investigation was to determine the antihelminthic effect of ivermectin and doramectin on weaned cattle from Abaí and Caapucú (Departments of Caazapá and Paraguari, Paraguay). For this purpose, stool samples of 40 bovine with parasitic loads higher than 400 eggs per gram were collected and divided into two groups of twenty animals each. One group was medicated with ivermectin and the other with doramectin, in both cases with a dose of 0,2 mg/kg subcutaneously. A second treatment was repeated 15 days later. The coprological analyses (McMaster technique) were made at 15, 30, 45 and 60 days. At the end of the assay, levels of 83 and 8 eggs per gram of feces (p<0,05) were determined for ivermectin and doramectin groups, respectively. Although both drugs caused the decrease of eggs per gram, the effect of doramectin was clearly higher compared to ivermectin.

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Section: Resultados Y Discusiónunclassified

Efecto antihelmíntico de ivermectina y doramectina en bovinos destetados del sur paraguayo

et al. 2019

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“…The problem is greater under intensive grazing systems in humid and warm regions where a high level of infection occurs, and particularly with high stocking rates. The adverse effects of trichostrongyle infection have been minimised by introducing control programmes (Fisher and Jacobs 1995, Eysker and others 1998), based on epidemiological knowledge and on the ability of modern anthelmintic compounds to remove worms from the host, combined with specific management practices (Herd 1988, Williams and others 1988,1997, Craig 1995). The environmental conditions in humid and warm temperate regions of both the northern and southern hemispheres allow for long growing seasons and year‐round grazing, with the opportunity for near optimal larval development in most months.…”

Section: Methodsmentioning

confidence: 99%

“…A longer period of protection against infective trichostrongyle larvae will delay egg excretion, leading to a lower level of contamination on pastures. Macrocyclic lactone molecules have been shown to persist longer than other anthelmintic compounds (Armour and others 1985, Weatherley and others 1993, Entrocasso and others 1996, Williams and others 1997). Recently, new long‐acting formulations have been developed to extend the anthelmintic activity of the avermectin family, and they have been marketed worldwide.…”

Section: Methodsmentioning

confidence: 99%

Effects of treatments with endedocide on the weight gain of grazing cattle in a warm temperate climate

Mercier

Steffan

White³

2001

Veterinary Record

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Five groups of 20 weaned beef calves were injected subcutaneously with either an ivermectin, a doramectin, an abamectin long-acting formulation, an ivermectin long-acting formulation or a saline control, at turnout and 60 and 120 days later. The animals grazed the same pasture and were sampled and weighed at turnout and 30, 60, 90, 120, 150 and 180 days later. At turnout the mean bodyweights of all the groups were similar and faecal culture showed that they had a mixed strongyle infection of Cooperia, Haemonchus, Ostertagia, Oesophagostomum and Trichostrongylus species. After 180 days, the mean bodyweight gains of each group were respectively 62.1 kg, 102.2 kg, 106.4 kg, 107.3 kg and 110.1 kg for the control, ivermectin, doramectin, ivermectin long-acting and abamectin long-acting groups. All the products significantly improved the weight gains of the cattle, and significantly reduced their faecal egg counts.

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Section: Introductionmentioning

confidence: 99%

“…The advantages of persistent anthelmintic efficacy of the injectable formulations of IVM, DRM and MXD in strategical programs for controlling gastrointestinal nematodes and lungworm in cattle are well documented (Williams et al, 1992(Williams et al, , 1997Jones et al, 1993). However, some studies have shown that cattle treated with MXD pour-on achieved an advantage over the other endectocide compounds in attaining a highly and persistent level of nematode control and weight gains in beef calves (Williams et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Licking induced changes to the pattern of moxidectin milk elimination after topical treatment in dairy cows

Imperiale

Sallovitz

Farías

et al. 2009

Vet Pharm & Therapeutics

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Pour-on administration of the macrocyclic lactones anti-parasitic compounds in beef and dairy cattle is now worldwide accepted. However, the information available on their milk excretion pattern, after topical administration is rather limited. Additionally, the cattle licking behaviour has been proven to affect the kinetics of these anti-parasitic compounds. The purpose of this study was to investigate the influence of the natural licking behaviour on the plasma and milk disposition of moxidectin (MXD), topically administered (500 microg/kg) in lactating dairy cows. Ten lactating Holstein dairy cows (705 kg body weight) were allocated into two experimental groups (n = 5). The licking was prevented during 5 days postadministration in animals in group I, and the remaining cows (group II) were allowed to lick freely. MXD concentrations profiles were measured in plasma and milk over 15 days posttreatment. The licking restriction period caused marked changes in MXD disposition kinetics both in plasma and milk. Both plasma and milk MXD concentrations (partial AUC 0-5 days) were significantly lower (P < 0.05) in licking-restricted cows. After the 5-day of restriction period, the animals were allowed to lick freely, which permitted the oral ingestion of MXD, situation clearly reflected both in plasma profile and milk excretion pattern. Despite the enhanced MXD milk concentrations measured in free-licking cows, drug concentrations did not reach the maximum MXD residues limit.

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Duration of anthelmintic efficacy of doramectin and ivermectin injectable solutions against naturally acquired nematode infections of cattle

Cited by 7 publications

References 8 publications

Efecto antihelmíntico de ivermectina y doramectina en bovinos destetados del sur paraguayo

Efecto antihelmíntico de ivermectina y doramectina en bovinos destetados del sur paraguayo

Effects of treatments with endedocide on the weight gain of grazing cattle in a warm temperate climate

Licking induced changes to the pattern of moxidectin milk elimination after topical treatment in dairy cows

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