Duration of Antibiotic Therapy in Sepsis Secondary to Urinary Stones: A Retrospective Observational Study

Béïque, L; Witherspoon, Luke; Zvonar, Rosemary; Suh, Kathryn N.; Squires, Janet; Roberts, Matthew; Rowe, Neal; Watterson, James; Nott, Caroline

doi:10.4212/cjhp.v72i4.2921

Cited by 2 publications

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“…In this study, it was suggested that higher satisfaction levels were observed in the study group than in the control group, indicating that the combined approach more effectively fulfills patients' physical and psychological needs, liorate pain and enhance sleep quality. Due to widespread neglect of urinary calculi, recurrent episodes are common, significantly contributing to patients' feelings of despair [24,25].…”

Section: Discussionmentioning

confidence: 99%

Effects of integrated nursing and psychological intervention on pain relief and patient satisfaction in urinary calculi patients

Chen

2024

Am J Transl Res

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January 2020 and June 2022. Participants were divided into a control group (n=48), receiving routine nursing and psychological intervention, and a study group (n=46), receiving integrated nursing and psychological intervention. We compared pain intensity, pain relief rate, patient satisfaction, Numeric Rating Scale (NRS) score, Pittsburgh Sleep Quality Index (PSQI) score, Self-rating Depression Scale (SDS) score, Self-rating Anxiety Scale (SAS) score, and quality of life scores between the groups. Results: The study group had shorter hospital stays and lower hospitalization costs than the control group (both P < 0.05). Pain relief and satisfaction rates were higher in the study group (both P < 0.05). Post-intervention, both groups showed significant reductions in NRS, PSQI, SDS, and SAS scores, with greater reductions in the study group (all P < 0.05). Quality of life scores increased in both groups, more so in the SG (P < 0.05). The study group also had fewer adverse events (P < 0.05). Both groups showed decreased serum creatinine and blood urea nitrogen levels post-intervention, with a more significant decline in the study group (P < 0.05). Education, marital status, and occupation were major factors influencing outcomes in urinary calculi patients. Conclusion: Integrated nursing and psychological intervention significantly alleviates pain, improves emotional well-being, enhances sleep quality, increases overall life quality, and contributes to high patient satisfaction among urinary calculi patients.

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Section: Discussionmentioning

confidence: 99%

Effects of integrated nursing and psychological intervention on pain relief and patient satisfaction in urinary calculi patients

Chen

2024

Am J Transl Res

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“…One study showed that urogenous sepsis is a dangerous complication after PCNL ( 21 ). The occurrence of urogenous sepsis not only aggravates the primary disease and reduces the effect of PCNL surgery but also prolongs the treatment time and increases the treatment cost and the risk of death, which has become one of the issues of high clinical concern.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and predictors of urogenous sepsis after percutaneous nephrolithotomy for idiopathic calcium oxalate nephrolithiasis

Chen¹,

Li²,

Chen³

et al. 2023

Transl Androl Urol

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Background The aim of this study was to use bioinformatics approaches to screen and identify the key genes of idiopathic calcium oxalate nephrolithiasis, and explore its potential molecular mechanism. Methods The GSE73680 kidney stone data set was downloaded from the Gene Expression Omnibus (GEO). R software (The R Foundation for Statistical Computing) was used to screen differentially expressed genes. GeneMANIA and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) databases were used to analyze related genes interacting with crucial genes, and a protein-protein interaction (PPI) network was constructed. The differential genes were then subjected to the Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment analysis using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) database. The clinical data of 156 patients who received percutaneous nephrolithotomy (PCNL) therapy at our facility between January 2013 and December 2017 were retrospectively analyzed. The various parameters associated with postoperative urogenous sepsis were identified using multivariable logistic regression analysis. Results The study discovered one differentially expressed gene was nucleotide-binding oligomerization domain-containing protein 2 ( NOD2 ). GO and KEGG analysis showed that NOD2 might affect the occurrence of idiopathic calcium oxalate kidney stones by affecting inflammation, receptor expression, immune environment, necrosis, apoptosis, and other pathways. The clinical parameter of patients who participated in the study, including preoperative urinary white blood cell (WBC) count, preoperative urinary nitrite, stone diameter, operation time, WBC count, and WBC D values, were statistically different between the systemic inflammatory response syndrome (SIRS) group and the urosepsis group. According to multivariate logistic regression analysis, the preoperative urine nitrite, calculus diameter, blood WBC, and NOD2 expression 3 hours after surgery were all independently associated with the urosepsis development. Conclusions Preoperative urinary nitrite positive status, postoperative WBC count ≥2.98×10 9 /L 3 hours after operation, stone diameter >6 cm, and low expression of NOD2 in renal papillary tissue are more likely to cause the urinary source of idiopathic calcium oxalate nephrolithiasis after PCNL urogenous sepsis. These parameters also offer a viable treatment paradigm for the perioperative management of PCNL in treating idiopathic calcium oxalate kidney stones.

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Duration of Antibiotic Therapy in Sepsis Secondary to Urinary Stones: A Retrospective Observational Study

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Cited by 2 publications

References 7 publications

Effects of integrated nursing and psychological intervention on pain relief and patient satisfaction in urinary calculi patients

Effects of integrated nursing and psychological intervention on pain relief and patient satisfaction in urinary calculi patients

Risk factors and predictors of urogenous sepsis after percutaneous nephrolithotomy for idiopathic calcium oxalate nephrolithiasis

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