Duration of Caffeine for Apnea of Prematurity—A Randomized Controlled Trial

Pournami, Femitha; Prabhakar, Jyothi; Nandakumar, Anand; Nair, P. M. C.; Jain, Naveen

doi:10.1007/s12098-021-03659-y

Cited by 11 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Likewise, there is no clear expert consensus as to when caffeine treatment should be discontinued. In a study of neonates of 26 to 32 weeks' gestational age with AOP, 120 infants were randomized to be treated with caffeine until the seventh apnea-free day or for a fixed time period that culminated at 34 weeks of postmenstrual age [34]. Results were similar between groups, and the study suggests that caffeine may be stopped as early as 33 to 34 weeks of postmenstrual age without risking recurrence of apnea [34].…”

Section: Methylxanthinementioning

confidence: 96%

“…In a study of neonates of 26 to 32 weeks' gestational age with AOP, 120 infants were randomized to be treated with caffeine until the seventh apnea-free day or for a fixed time period that culminated at 34 weeks of postmenstrual age [34]. Results were similar between groups, and the study suggests that caffeine may be stopped as early as 33 to 34 weeks of postmenstrual age without risking recurrence of apnea [34]. A survey of caffeine use in neonates with AOP in the United States found that caffeine was most frequently discontinued at the postmenstrual age of 34 weeks (62%) and that most of them were not discharged home on caffeine therapy (70%) [35].…”

Section: Methylxanthinementioning

confidence: 99%

See 1 more Smart Citation

Treating Apnea of Prematurity

Pergolizzi¹,

Kraus²,

Magnusson³

et al. 2022

Cureus

View full text Add to dashboard Cite

Premature babies often suffer apnea of prematurity as a physiological consequence of an immature respiratory system. Hypercapnia may develop, and neonates with apnea of prematurity are at an increased risk of morbidity and mortality. The long-term effects of apnea of prematurity or their treatments are less clear. While a number of treatment options exist for apnea of prematurity, there is no clear-cut "first-line" approach or gold standard of care. Effective treatments, such as caffeine citrate, carbon dioxide inhalation, nasal continuous positive airway pressure, nasal intermittent positive pressure ventilation, and others, may be associated with safety concerns. More conservative treatments are available, such as kangaroo care, postural changes, and sensory stimulation, but they may not be effective. While apnea of prematurity resolves spontaneously as the respiratory system matures, it can complicate neonatal care and may have both short-term and long-term consequences. The role, if any, that apnea of prematurity may play in mortality of preterm neonates is not clear.

show abstract

Section: Methylxanthinementioning

confidence: 96%

Section: Methylxanthinementioning

confidence: 99%

Treating Apnea of Prematurity

Pergolizzi¹,

Kraus²,

Magnusson³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…Caffeine Therapy in Apnea of Prematurity: Traditional Review Özmert Muhammet Ali ÖZDEMİR a a Pamukkale Üniversitesi Tıp Fakültesi, Neonatoloji BD, Denizli, Türkiye Bu çalışma, Türk Neonatoloji Derneği "Prematüre Bebek Yönetimi; Deneyim ve Kanıta Dayalı Güncel Yaklaşımlar" Sempozyumu'nda (26)(27)(28)(29) Mayıs 2022, Antalya) sözlü olarak sunulmuştur.…”

Section: Prematüre Apnesinde Kafein Tedavisi: Geleneksel Derlemeunclassified

“…Ayrıca bu çalışmada, 26-29 GH ile 30-32 GH'yi içeren subgrup analizi yapıldığında; 29 gebelik haftası ve altında doğanlarda apne %74 sonlanırken, 30-32 GH'de apne %96 sonlanmakta, yani daha düşük gebelik haftasında doğanlarda apne tekrarının daha fazla görüldüğü bildirilmiştir. 27 Chung ve ark.nın 2010-2017 yılları arasında ≤1.500 g prematüre bebeklerde (n=686) yaptıkları bir başka çalışmada; 30 GH ve altında doğanlara rutin, 30 GH üstünde doğanlara ise semptomatik olanlara standart kafein tedavisi (20 mg/kg yükleme ve 5-10 mg/kg/gün idame) uygulanmıştır. 28 Düzeltilmiş yaşı 34 haftaya ulaştığında; apnesi olmayan veya 3-4 gün apne ile ilişkili semptomu saptanmayanlarda kafein kesilmiş, bu bebeklerden 280'i kafein kesildikten sonra kan kafein düzeyleri ile izleme alınmıştır.…”

Section: Kafein Etki Mekanizmasiunclassified

Caffeine Therapy in Apnea of Prematurity: Traditional Review

ÖZDEMİR¹

2023

Turkiye Klinikleri J Pediatr

View full text Add to dashboard Cite

prematurity, increases neural excitation by preventing gammaaminobutyric acid release, increases the sensitivity of the central nervous system to blood carbon-dioxide levels, thus it stimulates and maintains respiration in infants with apnea. In this review, the effect of caffeine, which is the first choice in the treatment of apnea in premature infants, information about who, when, in which dose, and for how long we should use it, has been tried to be given in the light of the recent literature data.

show abstract

“…Prakash and colleagues explored optimum duration of therapy by comparing continuation of caffeine till 34 wk postmenstrual age (PMA) vs. stopping caffeine after a 7 d apnea-free period, in neonates of 26-32 wk gestation [2]. They were willing to accept a 10% absolute difference in the incidence of 'recurrence of apnea of prematurity (RAP)' against a presumed baseline risk of 1% among those given caffeine till 34 wk PMA.…”

mentioning

confidence: 99%