2016
DOI: 10.1093/infdis/jiw122
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Duration of Dengue Viremia in Blood Donors and Relationships Between Donor Viremia, Infection Incidence and Clinical Case Reports During a Large Epidemic

Abstract: These parameters allow projections of dengue incidence from donor NAT yield data and vice versa, and suggest that viremic donations will be rare relative to clinical disease cases.

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Cited by 57 publications
(62 citation statements)
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“…Furthermore, ZIKV and DENV neutralization tests were performed on follow‐up samples from IgM positive individuals using reporter virus particles (RVP; Integral Molecular). These assays involve parallel titration of donor serum on RVPs bearing the structural proteins of ZIKV and the four DENVs, as previously described …”
Section: Methodsmentioning
confidence: 99%
“…Furthermore, ZIKV and DENV neutralization tests were performed on follow‐up samples from IgM positive individuals using reporter virus particles (RVP; Integral Molecular). These assays involve parallel titration of donor serum on RVPs bearing the structural proteins of ZIKV and the four DENVs, as previously described …”
Section: Methodsmentioning
confidence: 99%
“…Surprisingly, NAT has detected only five DENV positive donations since its introduction in blood screening in FP in 2013, accounting for a rate of 0·018% which is 30 times lower than what was reported in Brazil in 2012 . Mini pool NAT impairs the sensitivity of the screening and hence could have underestimated the number of positive donations as it was reported that the DENV RNA loads in blood donors are not very high (median 2·3–3·5 log copies/ml) . However, in contrast to Brazil, which was experiencing an epidemic during the study period, the circulation of DENV in FP over the past four years was low as suggested by the high prevalence (80%) of anti‐DENV antibodies in the FP adult population explaining the low NAT yield .…”
Section: Discussionmentioning
confidence: 74%
“…Surprisingly, NAT has detected only five DENV positive donations since its introduction in blood screening in FP in 2013, accounting for a rate of 0·018% which is 30 times lower than what was reported in Brazil in 2012 . Mini pool NAT impairs the sensitivity of the screening and hence could have underestimated the number of positive donations as it was reported that the DENV RNA loads in blood donors are not very high (median 2·3–3·5 log copies/ml) .…”
Section: Discussionmentioning
confidence: 90%
“…There is limited knowledge about the magnitude of viremia in RRV‐infected individuals, and there is no understanding of a threshold quantity of infectious RRV particles required for transfusion transmission. Investigating these paucities in our understanding could involve large‐scale donor‐recipient clinical studies, similar to those performed previously for other arboviruses . Mouse studies suggest that viremia is at its highest 1 day after infection (23,820 copies/µL), persisting for 5 days in most cases (average, 37 copies/µL), but can be extended to 9 days at a low viral load (6 copies/µL) in some individuals .…”
Section: Discussionmentioning
confidence: 94%