Duration of environmental enrichment influences the magnitude and persistence of its behavioral effects on mice

Amaral, Olavo B.; Vargas, Rafael S.; Hansel, Gisele; Izquierdo, Iván; Souza, Diogo O.

doi:10.1016/j.physbeh.2007.09.009

Cited by 58 publications

(49 citation statements)

References 34 publications

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“…For example, Kobayashi et al [29] observed that cognitive functions of adult rats were improved to a similar extent after a shorter (3 months) and longer (>14 months) enrichment, while the improvement was stronger after the long enrichment in aged rats. In addition, Amaral et al [2] reported that reduced locomotion behavior in an open field persisted after a prolonged (8 weeks), but not after a shorter (4 weeks), housing duration. This discrepancy between the effect of EE on the physiological properties and on the behavioral measures has recently been pointed out by Eckert and Abraham [10].…”

Section: Environmental Enrichment Increased Cellular Excitability In mentioning

confidence: 99%

Environmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner

Valero-Aracama

Sauvage

Yoshida

2015

Behavioural Brain Research

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Section: Environmental Enrichment Increased Cellular Excitability In mentioning

confidence: 99%

Environmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner

Valero-Aracama

Sauvage

Yoshida

2015

Behavioural Brain Research

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“…In experimental models, some authors have described how exposure to enriched environments prevents the effects of dark-rearing on the rat visual cortex [65]. Recent studies have outlined the importance of the duration of environmental enrichment, as this is relevant to the persistence of its effects on behaviour [66].…”

Section: Environmental Enrichmentmentioning

confidence: 99%

Vascular Endothelial Growth Factor: Adaptive Changes in the Neuroglialvascular Unit

Argandoña

Bengoetxea²,

Ortuzar³

et al. 2012

CNR

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Brain postnatal development is modulated by adaptation and experience. Experience-mediated changes increase neuronal activity leading to increased metabolic demands that involve adaptive changes including ones at the microvascular network. Therefore, vascular environment plays a key role in central nervous system (CNS) development and function in health and disease. Trophic factors are crucial in CNS development and cell survival in adults. They participate in protection and proliferation of neuronal, glial and endothelial cells. Among the most important molecules are: the proangiogenic vascular endothelial growth factor (VEGF), the neurotrophin brain derived neurotrophic factor (BDNF), insulin growth factor (IGF-I) and the glycoprotein erythropoietin (EPO). We propose the term angioglioneurins to define molecules acting on the three components of the neurogliovascular unit. We have previously reported the effects of environmental modifications on the three components of the neurogliovascular unit during the postnatal development. We have also described the main role played by VEGF in the experience-induced postnatal changes. Angioglioneurin administration, alone or in combination with other neuroprotective strategies such as environmental enrichment, has been proposed as a non-invasive therapeutic strategy against several CNS diseases.

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“…However, studies conducted with mice in age groups similar to those used here did not find significant results for spatial memory tasks 7,8,15 . EE duration seems to influence the magnitude of behavior effects in mice, as do the age when they are housed 16 and the EE protocols used 17 . A long duration EE is associated with higher habituation to novelty and hippocampal neurogenesis in mice 18 .…”

Section: Discussionmentioning

confidence: 99%

The influence of enriched environment on spatial memory in Swiss mice of different ages

Druzian

Melo

Souza

2015

Arq. Neuro-Psiquiatr.

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The objective of this study was to evaluate the influence of enriched environment on spatial memory acquisition in mice of three different age groups. Weanling, young, and young adult female Swiss mice were housed in a standard control or enriched environment for 50 days, and their spatial memory was tested with the Morris Water Maze. We did not observe an experimental effect for spatial memory acquisition, and there was neither an effect of time of analysis nor an interaction between experimental group and time of analysis. Regarding effects of experimental group and training day in relation to latency in finding the hidden platform, we did find an effect in the experimental young adult mice group (p = 0.027), but there was no interaction between these factors in all three groups. Based on these findings environmental enrichment did not enhance spatial memory acquisition in female Swiss mice in the tested age groups.

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Duration of environmental enrichment influences the magnitude and persistence of its behavioral effects on mice

Cited by 58 publications

References 34 publications

Environmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner

Environmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner

Vascular Endothelial Growth Factor: Adaptive Changes in the Neuroglialvascular Unit

The influence of enriched environment on spatial memory in Swiss mice of different ages

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