Duration of Exercise as a Key Determinant of Improvement in Insulin Sensitivity in Type 2 Diabetes Patients

Abstract

Exercise duration and intensity are important parameters in exercise prescription and play a major role in improving insulin sensitivity (including transient and persistent improvement effects following cessation of training) in patients with type 2 diabetes mellitus (T2DM). However, whether duration or intensity of exercise is the more important factor has yet to be established. Therefore, we aimed to determine whether exercise prescriptions differing in duration and intensity differ in their ability to aid T2DM patients to retain insulin sensitivity following the conclusion of a period of training. Sedentary T2DM patients (age 51.2 ± 1.3 years) were assigned to either a low-intensity (50% V 4 O 2peak , n = 27) or a high-intensity exercise group (75% V 4 O 2peak , n = 28), and followed a 12-week exercise program of 5 sessions/week and 240 kcal/session. Insulin sensitivity (oral glucose tolerance test, ISI) was measured when subjects were sedentary and at 16-24 h and 15 days after the final training bout. The low-intensity group spent more training time to training per exercise session than the high-intensity group (56.1 ± 3.0 min/session vs. 34.3 ± 2.4 min/ session) (P < 0.01), but the total amount of energy expended was the same. ISI was increased in both groups 16-24 h after the final training session, but only the low-intensity group still had elevated ISI 15 days after the cessation of training. These findings suggest that in T2DM patients, the persistent traininginduced improvements in insulin sensitivity may be more dependent on exercise duration than exercise intensity in regimens with the same level of energy expenditure.

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“…Obtained results showed that our training program has positively influenced glucose uptake and insulin action. Our study results are in accordance with another study result's conducted by Jing Li and colleagues [18]. In their study titled "Duration of exercise as a key determinant of improvement in insulin sensitivity in type 2 diabetes", they observed an increased glucose uptake and insulin action improvement even 15 days after exercise training cessation.…”

Resistance to the Beneficial Effects of Exercise in Type 2 Diabetes: Are Some Individuals Programmed to Fail?

“…In one report, a greater and more persistent training effect was observed in individuals in a low volume/moderate intensity exercise training group compared to individuals in a low volume/vigorous intensity group (33). Other studies have reported that duration of exercise is also critical in determining the magnitude of the training effect regardless of volume or intensity (42,78). Furthermore, recent evidence demonstrated that the type-and not duration-of exercise was the key to improvements in HbA1c levels in individuals with T2D (34).…”

Near‐normalization of glycaemic control with glucagon‐like peptide‐1 receptor agonist treatment combined with exercise in patients with type 2 diabetes

“…Physical activity is one of the three cornerstone recommendations (along with diet and medication) in the treatment of type 2 diabetes . Exercise training improves aerobic capacity and muscular strength and is often associated with fat loss and increased muscle mass.…”