Duration of Influenza A Virus Shedding in Hospitalized Patients and Implications for Infection Control

Leekha, Surbhi; Zitterkopf, Nicole L.; Espy, Mark J.; Smith, Thomas F.; Thompson, Rodney L.; Sampathkumar, Priya

doi:10.1086/520101

Cited by 126 publications

(105 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is important to notice how good the fitting process is despite the irregularity of the data and the stochastic process underlying the proposed SEIR network model. The best fitted random networks have values around ω = 1 5 and ρ = 1 7 , which are in good agreement with the medical data regarding AH1N1 influenza virus [1,37,38].…”

Section: Random Network Model Fittingsupporting

confidence: 83%

See 1 more Smart Citation

Modelling influenza A(H1N1) 2009 epidemics using a random network in a distributed computing environment

et al. 2015

View full text Add to dashboard Cite

In this paper we propose the use of a random network model for simulating and understanding the epidemics of influenza A(H1N1). The proposed model is used to simulate the transmission process of influenza A(H1N1) in a community region of Venezuela using distributed computing in order to accomplish many realizations of the underlying random process. These large scale epidemic simulations have recently become an important application of high-performance computing. The network model proposed performs better than the traditional epidemic model based on ordinary differential equations since it adjusts better to the irregularity of the real world data. In addition, the network model allows the consideration of many possibilities regarding the spread of influenza at the population level. The results presented here show how well the SEIR model fits the data for the AH1N1 time series despite the irregularity of the data and returns parameter values that are in good agreement with the medical data regarding AH1N1 influenza virus. This versatile network model approach may be applied to the simulation of the transmission dynamics of several epidemics in human networks. In addition, the simulation can provide useful information for the understanding, prediction and control of the transmission of influenza A(H1N1) epidemics.

show abstract

Section: Random Network Model Fittingsupporting

confidence: 83%

“…Therefore, the mean time in the exposed class E(t) has been assumed such that ω = 1 6 days −1 . The infectious period has been reported between four and seven days with ρ = 1 7 days −1 [37,38]. However, in young children and in immunocompromised or severely ill patients, the infectious period might be longer [39].…”

Section: Methodsmentioning

confidence: 99%

Modelling influenza A(H1N1) 2009 epidemics using a random network in a distributed computing environment

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In seasonal influenza, prolonged viral shedding can occur in children,15 immunocompromised people,16 and elderly hospitalized patients with comorbidities 17. With regard to 2009 H1N1 influenza, Ling et al 18.…”

Section: Discussionmentioning

confidence: 99%

Factors promoting the prolonged shedding of the pandemic (H1N1) 2009 influenza virus in patients treated with oseltamivir for 5 days

Ryoo

Kim

Sohn

et al. 2012

Influenza Resp Viruses

View full text Add to dashboard Cite

BackgroundThe duration of viral shedding is an important determinant of infectivity and transmissibility and provides vital information for effective infection prevention and control. However, few studies have evaluated viral shedding in patients admitted to hospital with 2009 H1N1 influenza and treated with oseltamivir.ObjectiveTo determine the incidence of prolonged 2009 H1N1 influenza viral shedding in patients treated for 5 days with oseltamivir and to identify factors that promote prolonged viral shedding.MethodsThis was a prospective, observational cohort study of 173 patients infected with 2009 H1N1 influenza (confirmed by RT‐PCR) who were admitted to isolation rooms in the emergency department of our hospital between August 25, 2009 and December 31, 2009. All of the patients were treated according to institutional protocols and received routine follow‐up RT‐PCR testing after 5 days of oseltamivir therapy. Prolonged viral shedding was defined as a positive follow‐up RT‐PCR result.ResultOf the 173 patients in our cohort, 88 (50·8%) showed persistent viral shedding after oseltamivir treatment. Viral shedding was significantly prolonged if antiviral therapy was started ≥2 days after symptom onset (OR 2·74, 95% CI 1·29–5·82), if there were major comorbidities (OR 3·07, 95% CI 1·29–7·32), and/or if respiratory symptoms were still present on the day 5 of antiviral treatment (OR 4·13, 95% CI 2·10–8·11).ConclusionsThe presence of major comorbidities, a delay in initiating antiviral treatment, and continuing respiratory symptoms after 5 days of antiviral treatment are associated with prolonged shedding of the 2009 H1N1 influenza virus.

show abstract

“…The median age of the patients was 44.2 years, and all of the patients had an established haematologic disease, having received at least one round of bone marrow transplantation. Patient one recovered from the acute virus infection and displayed prolonged virus shedding, as has been described by others [8,11]. Excluding this patient, the duration of the outbreak was 22 days (calculated from the first to the last detection of virus in the patients).…”

Section: Introduction Of Control Measuresmentioning

confidence: 66%

Outbreak of influenza virus A/H1N1 in a hospital ward for immunocompromised patients

2010

View full text Add to dashboard Cite

Duration of Influenza A Virus Shedding in Hospitalized Patients and Implications for Infection Control

Cited by 126 publications

References 20 publications

Modelling influenza A(H1N1) 2009 epidemics using a random network in a distributed computing environment

Modelling influenza A(H1N1) 2009 epidemics using a random network in a distributed computing environment

Factors promoting the prolonged shedding of the pandemic (H1N1) 2009 influenza virus in patients treated with oseltamivir for 5 days

Outbreak of influenza virus A/H1N1 in a hospital ward for immunocompromised patients

Contact Info

Product

Resources

About