Duration of labor with spontaneous onset at the University of Ilorin Teaching Hospital, Ilorin, Nigeria

Ijaiya, Munirdeen A; Adesina, KT; Raji, Hadijat Olaide; Aboyeji, Abiodun P.; Olatinwo, Abdul Waheed O..; Adeniran, Abiodun S; Adebara, Idowu; Isiaka-Lawal, Salamat

doi:10.4103/1596-3519.82074

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Additionally, various tissues, organs and factors are involved in the process of parturition; this includes endocrine and paracrine signaling by the mother and the fetus, involving hormones secreted from the placenta, fetal membranes, uterus, decidua and other adjacent tissues, cytokines produced in the uterus, and smooth muscle cell membrane receptors. Alterations in these signaling mechanisms ultimately induce contraction of the uterine smooth muscle, leading to parturition ( 3 – 6 ). This evidence suggests that uterine smooth muscle contraction is a crucial trigger of the childbirth process.…”

Section: Introductionmentioning

confidence: 99%

Roles and mechanisms of TRPC3 and the PLCγ/PKC/CPI-17 signaling pathway in regulating parturition

et al. 2017

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The aim of the current study was to investigate the role of phospholipase C (PLC)γ/protein kinase C (PKC)/C-kinase-activated protein phosphatase-1 (CPI-17) signaling pathways in uterine smooth muscle during parturition. Samples of uterine tissue were collected from pregnant patients who underwent a caesarean section for preterm delivery, full-term delivery with labor onset, full-term delivery without labor onset, and from a non-pregnant control group undergoing surgery for cervical intraepithelial neoplasia III. Immunohistochemistry, and western blotting were used to assess the association between TRPC3 levels and parturition and the influence of calcium ion channels. In addition, pregnant mice were used to explore the effect of uterine canonical transient receptor potential 3 (TRPC3) expression on the parturition-triggering mechanism and PLCγ/PKC/CPI-17 signaling pathways. Pregnant mouse uterine smooth muscle cells were cultivated, with and without TRPC3 silencing, and the expression levels of PLCγ, PKC and CPI-17, the upstream and downstream factors of the TRPC3 pathway, were measured in pregnant mouse uterine smooth muscle cells, in order to provide a theoretical basis for the prevention and treatment of premature labor. In the preterm and full-term without labor onset patient groups, the TRPC3 gene expression in the mSMCs was significantly overexpressed when compared with the non-pregnant group (P<0.05); however, TRPC3 expression was not elevated in the full-term with labor onset group, exhibiting no significant difference compared with the non-pregnant group (P>0.05). During pregnancy, compared with the non-pregnant controls, Cav1.2, Cav3.1 and Cav3.2 gene expression levels were markedly increased (P<0.05) in mSMCs from the preterm delivery group and the full-term with labor onset group, however were non-significantly increased in the full-term without labor onset group. The level of TRPC3 was highest in the preterm group, while the levels of Cav1.2, Cav3.1 and Cav3.2 were highest in the full-term with labor onset group. In the preterm, LPS-treated preterm and full-term groups, TRPC3, MAPK, ERK1/2, P-ERK, Cav3.2, Cav3.1 and Cav1.2 were all expressed at higher levels than in the unfertilized group. In the LPS-treated preterm group, the levels of TRPC3, MAPK, ERK1/2, P-ERK, Cav3.2, Cav3.1 and Cav1.2 were increased compared with the preterm group. Furthermore, following transfection of small interfering TRPC3 (siTRPC3) into cells, it was demonstrated that the levels of TRPC3, PLCγ, PKC, CPI-17, P-CPI-17, Cav1.2, Cav3.1 and Cav3.2 expression were lower in the LPS siTRPC3 group when compared with that of the LPS-treated untransfected control group.

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Section: Introductionmentioning

confidence: 99%

Roles and mechanisms of TRPC3 and the PLCγ/PKC/CPI-17 signaling pathway in regulating parturition

et al. 2017

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“…To assess the rate of oxytocin for labor augmentation, 41 studies were eligible, including either all women in labor, 16 , 22 , 33 , 34 , 40 , 41 , 42 , 43 vaginal births only, 9 , 31 , 37 , 39 , 44 , 45 , 46 women with uncomplicated singleton cephalic pregnancies at term, 11 , 17 , 18 , 19 , 32 , 35 , 38 , 47 , 48 , 49 , 50 , 51 or other criteria. 36 , 52 , 53 , 54 Data collection methods were by nonvalidated medical records, 11 , 16 , 17 , 19 , 28 , 32 , 33 , 40 , 41 , 42 , 43 , 45 , 46 , 51 , 54 clinical observations, 9 , 18 , 28 , 31 , 34 , 35 , 36 , 37 , 38 , 48 , 49 , 50 , 53 questionnaires, ...…”

Section: Resultsmentioning

confidence: 99%

“… 36 , 52 , 53 , 54 Data collection methods were by nonvalidated medical records, 11 , 16 , 17 , 19 , 28 , 32 , 33 , 40 , 41 , 42 , 43 , 45 , 46 , 51 , 54 clinical observations, 9 , 18 , 28 , 31 , 34 , 35 , 36 , 37 , 38 , 48 , 49 , 50 , 53 questionnaires, 44 or interviews with women, 39 , 47 whereas 4 studies had no methods described. 18 , 23 , 29 , 52 Studies reported up to 24% missing data. 30 , 33 , 45 , 46 Figure 2 presents average rates of oxytocin for labor augmentation in each country in studies after the year 2000.…”

Section: Resultsmentioning

confidence: 99%

Labor augmentation with oxytocin in low- and lower-middle-income countries: a systematic review and meta-analysis

Kujabi

MIKKELSEN

Housseine

et al. 2022

AJOG Global Reports

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Prevention of primary caesarean delivery: comprehensive management of dystocia in nulliparous patients at term

Ragusa

Gizzo

Noventa

et al. 2016

Arch Gynecol Obstet

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Duration of labor with spontaneous onset at the University of Ilorin Teaching Hospital, Ilorin, Nigeria

Abstract: Interestingly, duration of labor was not significantly different among multiparas and nulliparas although it was shorter. Correlation existed between duration of labor and maternal age and individual parity.

Cited by 5 publications

References 17 publications

Roles and mechanisms of TRPC3 and the PLCγ/PKC/CPI-17 signaling pathway in regulating parturition

Roles and mechanisms of TRPC3 and the PLCγ/PKC/CPI-17 signaling pathway in regulating parturition

Labor augmentation with oxytocin in low- and lower-middle-income countries: a systematic review and meta-analysis

Prevention of primary caesarean delivery: comprehensive management of dystocia in nulliparous patients at term

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