Duration of opioid use and association with socioeconomic status, daily dose and formulation: a two-decade population study in Queensland, Australia

Adewumi, Adeleke D.; Maravilla, Joemer Calderon; Alati, Rosa; Hollingworth, Samantha; Hu, Xuelei; Loveday, Bill; Connor, Jason P.

doi:10.1007/s11096-020-01079-0

Cited by 12 publications

(7 citation statements)

References 43 publications

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“…35,36 In addition to opioids and polysubstance use, there are multiple known characteristics of drug-induced death, including socioeconomic status (SES) and demographic characteristics. These traits are associated with long-term OA use 37,38 and drug-induced death. [39][40][41] Analyses of associations between filled prescriptions and drug-induced death should be adjusted for such characteristics due to possible mediation or confounding.…”

Section: Introductionmentioning

confidence: 99%

Patterns of filled prescriptions and the association with risk of drug‐induced death. A population‐based nested case‐control register study

Amundsen,

Odsbu,

Skurtveit

et al. 2024

Pharmacoepidemiology and Drug

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PurposeOpioid analgesics (OA) and other pharmaceuticals have been associated with drug‐induced deaths. However, there is a lack of knowledge regarding patterns of use of these pharmaceuticals in the population and regarding such associations. We identify and describe subgroups of people with different patterns of filled prescriptions of OA and other relevant pharmaceuticals and examine associations with drug‐induced deaths. In addition, we estimate the proportion of drug‐induced deaths with a filled OA prescription and OA as cause of death.MethodsA Norwegian population‐based nested case‐control register study with cases (drug‐induced deaths 2010–2018, N = 2388) and population controls matched for age, gender and year of inclusion (N = 21 465). Patterns of filled prescriptions for opioid analgesics (OA), benzodiazepines and benzodiazepine‐related drugs, gabapentinoids, ADHD medication and antidepressants/antipsychotics were explored by k‐means cluster analysis. Associations with drug‐induced deaths were estimated by conditional logistic regression adjusted for sociodemographic characteristics. Overlap of filled OA prescriptions and OA as cause of death was estimated.ResultsFive clusters were identified: ‘few prescriptions’, ‘weak OA’, ‘ADHD medication’, ‘sedative/psychiatric morbidity’ and ‘strong OA’. The ‘strong OA’ cluster had higher socioeconomic status compared to the other groupings. The risk of drug‐induced death was also highest in this cluster (OR = 35.5; CI 25.6–49.3) and, for 68% (CI 64–73) of cases, filled prescriptions for OA was indicated as the underlying cause of death.ConclusionsThe cluster analysis identified a subgroup with filled prescriptions of OA and other pharmaceuticals and a higher socioeconomic status than other subgroups. This subgroup had a high risk of drug‐induced death that needs to be addressed.

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Section: Introductionmentioning

confidence: 99%

Patterns of filled prescriptions and the association with risk of drug‐induced death. A population‐based nested case‐control register study

Amundsen,

Odsbu,

Skurtveit

et al. 2024

Pharmacoepidemiology and Drug

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“…The analgesia produced by opioids is derived by its complex interaction with receptors of the Central Nervous System [ 1 ]. Though effective and largely used worldwide [ 4 – 6 ], opioids are associated with a wide variety of pernicious side effects [ 1 , 7 ]. When administered at higher doses, the probability of addiction and abuse increases over the long-term [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…In Brazil, the more privileged the area, the higher the opioid sales [ 18 ]. However, in Australia, living in lower socioeconomic conditions was associated with a higher risk of receiving an opioid prescription [ 6 ]. Regarding dental insurance, the association with opioid use is still unclear [ 18 , 20 , 22 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Association of sociodemographic factors with the prescription pattern of opioids for dental patients: A systematic review protocol

et al. 2021

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Introduction Oral health practitioners are responsible for a significant share of opioid prescriptions that seem to be influenced by many aspects, including sociodemographic factors. However, there is no consensus on the factors associated with opioid prescription in Dentistry. Objective To identify whether patients’ sociodemographic factors are associated with the prescription pattern of opioids in Dentistry. Materials and methods This systematic review will include observational studies (cross-sectional, case-control, and cohort). Electronic searches will be conducted in MEDLINE (PubMed), EMBASE, Scopus, Web of science, LILACS, SciELO, and Google Scholar. Grey literature will also be consulted. Two independent reviewers will screen all retrieved articles for eligibility, extract data, and assess the methodological quality of the included studies. The results will be presented as a narrative synthesis and, where possible, a meta-analysis will be conducted. Certainty of the evidence will be assessed with the Grading of Recommendations, Assessment, Development, and Evaluation approach. Systematic review registration number PROSPERO CRD42020211226.

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“…However, long-term opioid therapy may result in dose escalation and opioid-induced hyperalgesia, a condition in which the patient becomes especially sensitive to painful stimuli. Furthermore, patients with the lowest SES had the highest probability of receiving opioid prescriptions for more than 4 mos 2 . The baseline pain levels of these patients may also be affected by conditions such as fibromyalgia or chronic regional pain syndrome.…”

mentioning

confidence: 99%

Clinical Staging, Concurrent Treatment, and Epidural Steroid Injection Delivery Technique in a Population With Low Socioeconomic Status

Miranda

Zia

2023

Am J Phys Med Rehabil

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Duration of opioid use and association with socioeconomic status, daily dose and formulation: a two-decade population study in Queensland, Australia

Cited by 12 publications

References 43 publications

Patterns of filled prescriptions and the association with risk of drug‐induced death. A population‐based nested case‐control register study

Patterns of filled prescriptions and the association with risk of drug‐induced death. A population‐based nested case‐control register study

Association of sociodemographic factors with the prescription pattern of opioids for dental patients: A systematic review protocol

Clinical Staging, Concurrent Treatment, and Epidural Steroid Injection Delivery Technique in a Population With Low Socioeconomic Status

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