Duration of periconceptional folic acid supplementation in women booking for antenatal care

Abstract

National and international guidelines recommend that all women planning a pregnancy should take a 400μg supplement of folic acid (FA) each day, starting periconceptionally prior to the closure of the neural tube (1,2) . In recent kinetic studies, it has been shown that it takes 12 weeks of daily supplementation with 400μg FA to achieve the level of red cell folate (RCF) associated with reduced risk of neural tube defects (NTDs) (3) . The aim of this cross-sectional observational study was to analyse in detail the use of FA supplementation including timing of commencement and duration of usage; in women presenting for antenatal care in the first trimester of pregnancy.Women were recruited at their convenience in the first trimester, and their clinical and sociodemographic details computerised. Maternal weight and height were measured and body mass index (BMI) calculated. Detailed FA supplementation questionnaires were completed under the supervision of a trained researcher. This study population was representative of the national obstetric population (4) .While almost all of the 856 women (96·7 %) were taking FA at enrolment; only one in four women took FA for at least 12 weeks preconceptionally (n = 208, 24·5 %). Amongst the women who supplemented with FA preconceptionally, 43·8 % (162/370) reported taking FA for less than the required 12 weeks to achieve optimal red cell folate (RCF) levels for NTD prevention. Amongst women who only took FA post-conceptionally, almost two-thirds (61 %) commenced it after day 28 of their pregnancy when the neural tube had already closed.As the timing and duration of FA supplementation is suboptimal both before and after conception, we recommend that current national FA guidelines need to be reviewed and revised to address these important issues.

The determinants of maternal homocysteine in pregnancy: findings from the Ottawa and Kingston Birth Cohort

“…Clinical trials may point to a benefit of preconception folic acid and/or multivitamin intake on the risk of pregnancy complications. Periconceptional uptake of folic acid is suboptimal worldwide, including in Canada (56)(57)(58)(59)(60)(61)(62)(63) . Therefore, promoting timely uptake in the wider population of reproductive-age women is necessary in addition to targeting at-risk groups.…”