Duration of Pregnancy After Carbon Dioxide Laser Conization of the Cervix

Raio, Luigi; Ghezzi, Fabio; Naro, Edoardo Di; Gómez, Ricardo; Lüscher, KP

doi:10.1097/00006254-199806000-00012

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“…However Sagot reported no significant difference in rate of preterm delivery in the same patients before and after laser conization (Sagot et al, 1995). There is association between the risk of preterm delivery and the cone specimens height of 1.0 cm or higher (Raio et al, 1997;Sadler et al, 2004). The height of cone specimens of our patients was 1.0-1.5 cm; but the risk of low birth weight infant was 10% which was not higher than the risk of 9.3-11.6% in our general population (data from 1998-2007 Vital Statistic Report of the Faculty of Medicine Siriraj Hospital).…”

Section: Discussionmentioning

confidence: 99%

Long Term Outcomes of Laser Conization for High Grade Cervical Intraepithelial Neoplasia in Thai Women

Wongtiraporn

Laiwejpithaya²,

Sangkarat³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Aim: To report long term outcomes of laser conization for high grade cervical intraepithelial neoplasia (CIN) in Thai women. Materials and Methods: A retrospective cohort study was conducted in patients undergoing laser conization due to abnormal cervical cytology suggesting neoplasia during 1989 to 1994 and having follow-up data until December 2010. Conization was performed under colposcopy using a 0.5-mm CO 2 laser beam with power density of 18,000-20,000 watts/cm 2 , and the surgical base was vaporized using a low power defocused beam. The follow-up protocol included cervical cytology and colposcopy. Long term outcome measures were failure rate (persistence and recurrence), post-conization status of transformation zone, and obstetric outcomes. Results: Of 104 patients undergoing conization, 71 had therapeutic conization for high grade CIN and were followed up for a median time of 115 (range 12-260) months. There was one case of persistent and one of recurrent disease comprising a failure rate of 2.8%. The post treatment transformation zone was well visualized in 68.3% of 63 patients with an intact uterus. Sixteen patients achieved 25 pregnancies; none had second trimester miscarriage. The obstetric outcomes were unremarkable. Conclusions: Laser conization under colposcopic visualization for the treatment of high grade CIN in Thai women has a low failure rate of 2.8%. The post-conization transformation zone could not be evaluated completely in approximately 30% of cases; therefore the follow-up protocol should include both cytology and colposcopy. Obstetric outcomes are not adversely affected by this therapeutic procedure.

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Section: Discussionmentioning

confidence: 99%