Duration of Response to Intramuscular Versus Low Dose Intradermal Hepatitis B Booster Immunization

The response to a booster dose, given by the same route 18 months after the completion of the primary vaccination scheme, was studied in hospital staff members who responded with anti-HBs levels in the range of 10-99 IU/l after three intradermal (i.d., n = 51) or intramuscular (i.m., n = 11) doses of recombinant hepatitis B virus (HBV) vaccine administered at 0, 1 and 6 months. At the time of boostering the anti-HBs levels had declined to < 10 IU/l in 44/51 (86%) of the i.d. and 10/11 of the i.m. vaccines. All i.m. and 90% of i.d. vaccinees responded to the booster dose with anti-HBs level > or = 10 IU/l, and with geonmetric mean titres 1,074 IU/l and 121 IU/l, respectively. It was concluded that all i.m. and 90% of i.d. vaccinees with an initial anti-HBs response of 10-99 IU/l after three doses of HBV vaccine (among whom the anti-HBs levels in the majority had declined < 10 IU/l) mounted an anti-HBs level > or = 10 IU/l after a booster dose. The anti-HBs concentrations were generally higher after i.m. than i.d. booster doses in accordance with the response to primary vaccination.

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Response to a booster dose 18 months after a low anti-HBs response (10–99 IU/l) to three doses of intradermally or intramuscularly administered recombinant hepatitis B vaccine

Struve

Aronsson

Frenning

et al. 1995

Infection

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Intradermal hepatitis B vaccination in a 300-bed primary care hospital: Experience with a recombinant vaccine in a four-dose schedule

McMaster

Roper

Carter

1993

American Journal of Infection Control

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Persistence of antibody to hepatitis B surface antigen after low-dose, intradermal hepatitis B immunization and response to a booster dose

Bryan¹,

Sjögren²,

MacArthy³

et al. 1992

Vaccine

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Duration of Response to Intramuscular Versus Low Dose Intradermal Hepatitis B Booster Immunization

Cited by 8 publications

References 16 publications

Response to a booster dose 18 months after a low anti-HBs response (10–99 IU/l) to three doses of intradermally or intramuscularly administered recombinant hepatitis B vaccine

Response to a booster dose 18 months after a low anti-HBs response (10–99 IU/l) to three doses of intradermally or intramuscularly administered recombinant hepatitis B vaccine

Intradermal hepatitis B vaccination in a 300-bed primary care hospital: Experience with a recombinant vaccine in a four-dose schedule

Persistence of antibody to hepatitis B surface antigen after low-dose, intradermal hepatitis B immunization and response to a booster dose

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