Duration of untreated depression influences clinical outcomes and disability

Ghio, Lucio; Gotelli, Simona; Cervetti, Alice; Respino, Matteo; Natta, Werner; Marcenaro, Maurizio; Serafini, Gianluca; Vaggi, Marco; Amore, Mario; Murri, Martino Belvederi

doi:10.1016/j.jad.2015.01.014

Cited by 139 publications

(85 citation statements)

References 19 publications

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“…Future studies should consider this variable when exploring the SI with MDD. 52 4) we did not distinguish between those with single and recurrent illness episodes and future studies can clarify this problem.…”

Section: Strengths and Limitationsmentioning

confidence: 61%

Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China

Ge¹,

Jiang²,

Wang³

et al. 2020

NDT

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These authors contributed equally to this work Background: A growing body of research suggests that major depressive disorder (MDD) is one of the most common psychiatric conditions associated with suicide ideation (SI). However, how a combination of easily accessible variables built a utility clinically model to estimate the probability of an individual patient with SI via machine learning is limited. Methods: We used the electronic medical record database from a hospital located in western China. A total of 1916 Chinese patients with MDD were included. Easily accessible data (demographic, clinical, and biological variables) were collected at admission (on the first day of admission) and were used to distinguish SI with MDD from non-SI using a machine learning algorithm (neural network). Results: The neural network algorithm distinguished 1356 out of 1916 patients translating into 70.08% accuracy (70.68% sensitivity and 67.09% specificity) and an area under the curve (AUC) of 0.76. The most relevant predictor variables in identifying SI from non-SI included free thyroxine (FT4), the total scores of Hamilton Depression Scale (HAMD), vocational status, and free triiodothyronine (FT3). Conclusion: Risk for SI among patients with MDD can be identified at an individual subject level by integrating demographic, clinical, and biological variables as possible as early during hospitalization (at admission).

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Section: Strengths and Limitationsmentioning

confidence: 61%

Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China

Ge¹,

Jiang²,

Wang³

et al. 2020

NDT

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“…Bei einer rechtzeitigen und adäquaten Therapie kann hingegen sowohl die Symptomatik verbessert als auch die Dauer der depressiven Episode auf durchschnittlich 4 Monate reduziert werden [12]. Der frühe Therapiebeginn ist entscheidend für den Behandlungserfolg depressiver Erkrankungen [13] und ein wichtiges Kriterium für die Rückkehr an den Arbeitsplatz [14].…”

Section: Introductionunclassified

Rückkehr an den Arbeitsplatz nach depressiver Erkrankung - Evaluation einer retrospektiven Fall-Kontroll-Studie eines betriebsnahen integrierten Versorgungsmodells

Reifferscheid

Wege

Riesbeck

et al. 2018

Fortschr Neurol Psychiatr

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“…Duration of untreated depression influences clinical outcomes and disability. 2 Late-diagnosed patients with BD may have more disadvantages. Impulsivity is a multidimensional feature of BD, as well as of many other psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Impulsivity, Unplanned Pregnancies, and Contraception Among Women with Bipolar Disorder

Eroğlu¹,

Luş

2020

NDT

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Background: Impulsivity is one of the principal symptoms of bipolar and related disorders (BD). Unsafe sex and unplanned pregnancies are serious problems in clinical practice. The aim of this study was to investigate impulsivity levels, contraception methods, and levels of planned pregnancies among women with bipolar and related disorders (WBD). Methods: Fifty-eight euthymic women with BD (bipolar disorder type I, II, or other) were matched by education levels with a control group of 59 healthy women. Data about their demographic, clinical-Barratt Impulsiveness Scale (BIS-11), Hamilton Depression Rating Scale, and Young Mania Rating Scale scores-and reproductive health features were obtained and compared between the groups. Results: No difference was found regarding BIS-11 (total, nonplanning, motor, and attentional subscales) scores between the WBD and control groups. The overall rate of contraception use was higher in WBD (96.6%), but they generally preferred "traditional" methods (i.e., withdrawal and calendar). The total rate of unplanned pregnancies in WBD was 49.52%. Rate of unplanned pregnancies in WBD was significantly different from women without bipolar disorder (49.52% vs 15.04%). Discussion: Levels of impulsivity in euthymic WBD under treatment were similar to those of healthy women in the control sample. WBD paid attention to contraception although they usually used traditional methods. The findings indicate that most WBD use contraception, yet the contraception is potentially ineffective especially if WBD have more unplanned pregnancies. The provision of an effective contraception method in WBD is suggested for all clinicians, in order to prevent sexually transmitted diseases and unplanned pregnancies, and thus protect the health of both mother and fetus.

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Duration of untreated depression influences clinical outcomes and disability

Cited by 139 publications

References 19 publications

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

Rückkehr an den Arbeitsplatz nach depressiver Erkrankung - Evaluation einer retrospektiven Fall-Kontroll-Studie eines betriebsnahen integrierten Versorgungsmodells

<p>Impulsivity, Unplanned Pregnancies, and Contraception Among Women with Bipolar Disorder</p>

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