2012
DOI: 10.1186/2045-3701-2-24
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DUSPs, to MAP kinases and beyond

Abstract: Phosphatases are important regulators of intracellular signaling events, and their functions have been implicated in many biological processes. Dual-specificity phosphatases (DUSPs), whose family currently contains 25 members, are phosphatases that can dephosphorylate both tyrosine and serine/threonine residues of their substrates. The archetypical DUSP, DUSP1/MKP1, was initially discovered to regulate the activities of MAP kinases by dephosphorylating the TXY motif in the kinase domain. However, although DUSP… Show more

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Cited by 235 publications
(237 citation statements)
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References 94 publications
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“…Similarly, the need for priming phosphorylation on ERK with DI and serum as well as the sustained pERK signal through several hours (Fig. 5E) could be explained if saccharin inhibited the dual specificity ERK phosphatases (60).…”
Section: Discussionmentioning
confidence: 96%
“…Similarly, the need for priming phosphorylation on ERK with DI and serum as well as the sustained pERK signal through several hours (Fig. 5E) could be explained if saccharin inhibited the dual specificity ERK phosphatases (60).…”
Section: Discussionmentioning
confidence: 96%
“…These components could either be an interacting protein physically inhibiting the conformation required for autophosphorylation or constitutive down-regulation by phosphatases. A candidate phosphatase could be MKP1, which is likely to bind the CD domain (43).…”
Section: Discussionmentioning
confidence: 99%
“…Dusp1, a key negative regulator of the MAP kinase signaling pathway (Huang and Tan, 2012), previously related to the pathophysiology of depression in humans and animal models of depression (Duric et al, 2010) was upregulated by uCMS exposure. Importantly, MAP kinase pathway has been previously implicated in synaptic plasticity (Duric et al, 2010;Sweatt, 2004) and may partly explain the altered neuroplasticity observed in the dDG of uCMS-exposed animals.…”
Section: Transcriptional Changes Induced By Ucms and Common Reversal mentioning
confidence: 95%