Dust Content, Radiology and Pathology in Simple Pneumoconiosis of Coalworkers (Further Report)

Rossiter, C. E.; Rivers, Desiree; Bergman, I.; Casswell, C.; Nagelschmidt, G.

doi:10.1016/b978-1-4832-1329-3.50041-x

Cited by 25 publications

(14 citation statements)

References 4 publications

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“…In the previous papers in this series (Rivers et al, 1960;Rossiter et al, 1967) there were not enough cases to be able to make a detailed study of subgroups. The re-analysis with further cases has shown that the material is not homogeneous; the Scottish subjects and those with a nodular pattern of small opacities on the radiographs show peculiar relations between radiological appearance and dust content of the lungs.…”

Section: Discussionmentioning

confidence: 85%

Relation between content and composition of coalworkers' lungs and radiological appearances

Rossiter

1972

Occupational and Environmental Medicine

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Rossiter, C. E. (1972). Brit. J. indusir. Med., 29,[31][32][33][34][35][36][37][38][39][40][41][42][43][44] Relation between content and composition of coalworkers' lungs and radiological appearances. The relation between radiological category of simple pneumoconiosis and dust content of the lung has been studied on a mixed group of 221 miners, of whom 76 had progressive massive fibrosis radiologically.The average radiological scores based on 11 independent readings for the films showing simple pneumoconiosis only were related, by multiple regression, to the coal, mineral, quartz, and iron contents of the lungs. Three subgroups were found which showed differing relations. Films of poor technique tended to be read in the middle categories whatever the content of the lungs. The lungs of Scottish miners all contained soot, from working in naked light pits, and their radiological scores were much higher than expected from the lung dust contents. The few films showing nodular sized small opacities were also over-read, suggesting that nodularity may be some response to dust other than simple accumulation. There were 98 subjects in the resulting homogeneous group of cases with simple pneumoconiosis only. On a revised scale to correct for slight non-linearity, the regression coefficients of radiological score on the total mineral and coal contents of the lung were in the ratio of 3*8 to 1. The iron content did not add much to this regression relation even though by itself it correlated well with the amount of simple pneumoconiosis. Probably most of the variation of radiological appearance with iron reflects variation with coal and mineral. The mineral and quartz contents were highly correlated (r = 0-96), but relations including quartz were not as close fitting as those including mineral. There was a small, but significant, residual relation of radiological score to years in coalmining.The background categories of simple pneumoconiosis in the 76 radiographs showing some evidence of progressive massive fibrosis were generally read higher than expected from the relation to dust content derived from the simple pneumoconiosis cases only. This was most true for those showing most evidence of progressive massive fibrosis.A series of 45 miners, almost exclusively from Nagelschmidt, 1956; Faulds. King, and NagelSouth Wales, was studied by Rivers, Wise, King, schmidt, 1959) had related content and composition and Nagelschmidt (1960), who compared the radio-of the dust to pathology, and Gough, James, and logical appearances of the miners' chest radiographs Wentworth (1949) had related radiological appeartaken shortly before death with the dust composition ance to pathology, this was the first study relating and content of their lungs. Although other workers radiological appearance to dust content and compo- (King and Nagelschmidt, 1945; King, Maguire, and sition, and to pathology. Rivers and his colleagues (1960), on the original series of 45 coalworkers' lungs, showed that the mineral content of the lung contributed nine time...

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Section: Discussionmentioning

confidence: 85%

Relation between content and composition of coalworkers' lungs and radiological appearances

Rossiter

1972

Occupational and Environmental Medicine

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“…The separation of p, m, and n types has not been so clearly validated. However, nodular cases have been shown to be more frequently associated with serum rheumatoid factors (Caplan et al, 1962), and lung dust analysis does not correlate so clearly with category as for the other types (Rossiter et al, 1967). A reduced gas transfer factor has been found to be associated with pinhead opacities (Englert and De Coster, 1965;Lyons et al, 1967), and the latter have also been linked with focal emphysema (Ryder et al, 1970).…”

Section: Inter-observer Errormentioning

confidence: 99%

An elaboration of small opacity types (p, m, and n) in simple pneumoconiosis

Lindars

1971

Occupational and Environmental Medicine

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“…Although proximal acinar emphysema attributable to the accumulation of coal mine dust cannot be read as such on radiographs, its existence apparently led to a marked degree of overreading of coniotic changes (25). Small rounded opacities of p-type were associated with more circumscribed emphysema than larger opacities (26,2 7), although irregular shadows exhibited a greater degree of emphysema, as well as a larger decrement in forced expiratory volume (FEV1) or gas transfer, than rounded ones (27,28).…”

Section: Human Responsesmentioning

confidence: 99%

“…Furthermore, it was estimated that the prevalence then obtaining should at least be halved during the succeeding 35 years, but overall progression appeared to be greater in men with some evidence of disease at the inception of the program. [25][26][27][28][29][30][31][32][33][34] 35-44 45-54 55-59 AGE FIGURE 1. Prevalence of pneumoconiosis, as a percentage of men Xrayed, in relation to age for 30 collieries surveyed repeatedly over a period of 22 years.…”

Section: Prevalence Dust Levelsmentioning

confidence: 99%

Prevalence and pathogenesis of pneumoconiosis in coal workers.

Heppleston

1988

Environ Health Perspect

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Dust dose and composition do not appear to account wholly for changes in the prevalence of coal workers' pneumoconiosis in Europe. In certain coal pits high progression evidently occurred with relatively low dust exposure or vice versa, whereas progression in relation to dust levels might be variable. Exceptionally high quartz concentrations occur in coal mine dust when pneumoconiosis may progress with unusual rapidity. Under such circumstances lesions resembling silicotic nodules may be found, but with the customarily lower levels of quartz the pathological features assume the form characteristic of coal workers. Morphological changes in relation to dust content of human and animal lungs, as well as cellular behavior, have not accounted completely for the epidemiological findings. Considering all the pathological evidence helps explain the pathogenesis of pneumoconiosis and vagaries of progression. The origin of progressive massive fibrosis cannot be explained simply in terms of dust burden or immunological features, and the role of an infective factor cannot be dismissed. Moreover, lipid secretion by alveolar epithelium introduces a new element that could affect the development of simple and complicated pneumoconiosis. In vitro, cytotoxicity appeared to be too variable for predictive purposes, though direct assay of fibrogenicity using the macrophage fibrogenic factor suggested that dust dose was more important than dust composition. Assessing individual susceptibility presents serious obstacles.

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Dust Content, Radiology and Pathology in Simple Pneumoconiosis of Coalworkers (Further Report)

Cited by 25 publications

References 4 publications

Relation between content and composition of coalworkers' lungs and radiological appearances

Relation between content and composition of coalworkers' lungs and radiological appearances

An elaboration of small opacity types (p, m, and n) in simple pneumoconiosis

Prevalence and pathogenesis of pneumoconiosis in coal workers.

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