“…Following the ISP study report (https://interstellarprobe.jhuapl.edu/ Interstellar-Probe-MCR.pdf; McNutt et al, 2022;Brandt et al, 2022b), a pragmatic mission concept (launch window starts in 2036), traveling well beyond the heliopause, and in anticipation of the IMAP mission (McComas et al, 2018) at ∼1 AU (launch in 2025) acting as a high-res "guide" to ISP, this paper highlighted the importance of studying the physics of the interactions pertaining to the expanding solar wind that meets the plasma, gas and dust flows of the VLISM, forming the complex and vast region of our astrosphere (see also Brandt et al, 2022a;Dialynas et al, 2022a;DeMajistre et al, 2022;Hill et al, 2022;Lavraud et al, 2022;Mostafavi et al, 2022;Opher et al, 2022;Provornikova et al, 2022;Sokół et al, 2022;Sterken et al, 2022). We focused on three fundamental open science questions that can only be addressed by exploiting a combination of in-situ charged particle, plasma waves and fields measurements with remotely sensed ENAs, that are measured simultaneously on the future ISP mission.…”