More than 635 000 positional observations of planets and spacecraft of different types, mostly radiotechnical ones , have been used for estimating possible changes of the gravitation constant, the solar mass, and semi-major axes of planets, as well as the value of the astronomical unit, related to them. The analysis of the observations has been performed on the basis of the EPM2010 ephemerides of IAA RAS in post-newtonian approximation.The EPM ephemerides are computed by numerical integration of the equations of motion of the nine major planets, the Sun, the Moon, asteroids and trans-neptunian objects.The estimation of change for the geliocentric gravitation constant GM ⊙ has been obtainedThe positive century changes of semi-major axes ȧi /a i have been determined simultaneously for the planets Mercury, Venus, Mars, Jupiter, Saturn provided with high-accuracy sets of the observations, as expected if the geliocentric gravitation constant is decreasing in century wise. Perhaps, loss of the mass of the Sun M ⊙ the produces change of GM ⊙ due to the solar radiation and the solar wind compensated partially by the matter dropping on the Sun.It was been found from the obtained GM ⊙ change and taking into account the maximal limits of the possible M ⊙ change that the gravitation constant Ġ/G falls within the interval −4.2 • 10 −14 < Ġ/G < +7.5 • 10 −14 in year with the 95% probability.The astronomical unit (au) is only connected with the geliocentric gravitation constant by its definition. The decrease of GM ⊙ obtained in this paper should correspond to the century decrease of au. However, it has been shown that the present accuracy level of observations does not permit to evaluate the au change. The attained possibility of fining the GM ⊙ change from high-accuracy observations points that fixing the connection between GM ⊙ and au at the certain time moment is desirable, as it is inconvenient highly to have the changing value of the astronomical unit.