Düşük Dozda N-Asetilsistein Uygulaması Diyabetik Yara İyileşmesini Hızlandırır mı?

Abstract

Oxidative stress and persistent inflammation play crucial role in the progression of diabetic wound complications. N-Acetylcysteine (NAC) is an amino acid derivative that promotes wound healing because of its ability of antioxidant properties. The aim of this study was to evaluate the effect of systemic NAC administration on oxidative stress, inflammatory markers, and collagen production in diabetic wound healing. Induction of diabetes was done by intraperitoneally administration of streptozotocin in Wistar rats. A dorsal circular wound was created in diabetic rats. After that subjects were treated with NAC (60 mg/kg) intraperitoneally to evaluate the wound healing potential of NAC. In the wound tissues of diabetic rats, lipid peroxidation and inflammatory markers were significantly increased (p<0.05). Superoxide dismutase and catalase activities, glutathione and NOx levels, and collagen production were significantly reduced in diabetic group (p<0.05). NAC administration increased antioxidant status and NOx levels, reduced lipid peroxidation and inflammatory marker levels in treated diabetic group compared to diabetic group (p<0.05). Additionally, in the diabetic NAC treatment group, collagen production was significantly increased and wound area was significantly smaller than diabetic group (p<0.05). Low dose NAC administration was found to be effective in diabetic wound healing by reducing oxidative stress and inflammation and increasing collagen production.