Dutasteride nanocapsules for hair follicle targeting: Effect of chitosan-coating and physical stimulus

Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence

“…Additionally, a mechanical massage upon skin application increased the amount of drug accumulated by about 5 times. 59 The systemic adverse reactions of cyclosporine, an immunosuppressive drug used against various autoimmune skin diseases (eg, areata alopecia and other scarring baldness), have also been proposed to be circumvented by topical application of PLA nanoparticles loading this drug. In this way, cyclosporine, which presented a limited skin penetration due to its high molecular weight and high lipophilicity, had its follicular uptake increased with the selective deposition of the 150 nm-nanoparticles compared to a non-colloidal vehicle.…”

“… [ 57 ] Diphencyprone and Minoxidil Nanostructured lipid carriers and nanoemulsions 177 and 194 Female nude mice (ICR-Foxn1nu) Follicular uptake by squarticles was 2- and 7-fold higher for diphencyprone and minoxidil, respectively, compared to the free drug controls. [ 58 ] Dutasteride Poly-(ɛ-caprolactone)-lipid-core, coated with chitosan nanoparticles 199 Skin from porcine ears Both coated and non-coated nanoparticles targeted the hair follicles compared to a drug solution, which is appropriate aiming the topical treatment of alopecia [ 59 ] Finasteride Liquid crystalline formulation 154–170 Dorsal skin of male hairless mice Liquid crystalline formulation increased the drug penetration in the skin compared with control. [ 34 ] Finasteride PLA nanoparticles 300 PDMS membrane as a simplified model of human epidermis The nanoparticles prolonged the time finasteride remained on the skin.…”

“…A manual massage of these nanocapsules upon skin application also increased latanoprost accumulation into the hair follicles by approximately 2 times. 62 This same polymer has already been used to prepare nanocapsules of dutasteride, 59 another highly lipophilic drug that acts as a selective and competitive inhibitor of both type-1 and type-2 isoenzymes of 5-α-reductase. 84 The nanocapsules were coated with chitosan to provide a positive surface charge to the nanosystem.…”

“…Additionally, a mechanical massage upon skin application increased the amount of drug accumulated by about 5 times. 59 …”

Comparing the delivery to the hair bulb of two fluorescent molecules of distinct hydrophilicities by different nanoparticles and a serum formulation

“…There are several reported studies that analyze the skin and follicular permeation of drug delivery systems (Abd et al, 2018;Blume-Peytavi et al, 2010;Lauterbach and Müller-Goymann, 2015;Ossadnik et al, 2006;Patzelt et al, 2011;Teichmann et al, 2007). Recently, some nanocarriers were developed to deliver topically drugs with interesting potential to treat acne vulgaris, hidradenitis suppurativa, androgenic alopecia and inflammation-based skin and hair disorders (Angelo et al, 2020;Pereira et al, 2021;Tolentino et al, 2021;Ushirobira et al, 2020). The authors have compared the developed vehicles with commercial ones or with the drug in solution and they have elegantly quantified which percentage of the drug penetrated into the skin specifically through the follicular pathway (Angelo et al, 2020;Pereira et al, 2021;Tolentino et al, 2021;Ushirobira et al, 2020).…”