Dutch validation of the low anterior resection syndrome score

Hupkens, B.; Breukink, Stéphanie O.; Briel, C. Olde Reuver of; Tanis, Pieter J.; Noo, Mirre E. de; Duijvendijk, Peter van; Westreenen, Henderik L. van; Dekker, Jan Willem T.; Chen, T. Y. T.; Juul, Therese

doi:10.1111/codi.14228

Cited by 40 publications

(52 citation statements)

References 21 publications

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“…The original Danish validation as well as some other translations, on the other hand, correlated the score with only one additional quality of life related question: "Overall, how much is your QoL influenced by your bowel dysfunction?," with four response options: "not at all," "a little," "some," or "a lot." (4,5,7,9) The discriminative validity of the arabic LARS score was equivalent to previous studies, with statistically significant differences according to tumor location, type of mesorectal excision, coloanal or colorectal anastomosis and administration or not of radiotherapy. As to age and sex, no significant difference has been accordingly proven.…”

Section: Discussionsupporting

confidence: 73%

Validation of the arabic version of the low anterior resection syndrome score

Essangri

Majbar²,

Benkabbou

et al. 2020

Preprint

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Purpose: Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome. The aim of this study is to translate this tool into arabic and test its psychometric properties in rectal cancer patients, in order to ease its use in clinical practice and future research. Methods: The LARS questionnaire was translated to arabic and administered to a total of 143 patients. A subgroup of 42 patients took the test twice for test-retest reliability. Internal consistency was examined through cronbach’s alpha. The score results were correlated to the EORTC QLQ-C30 questionnaire for convergent validity assessment while discriminant validity was established through the ability of the LARS score to differentiate patients with different clinical and pathological criteria. Results: The arabic version of the LARS score was completed by 143 patients. The internal consistency was demonstrated through a cronbach alpha score of 0.66. The agreement between the test and retest was established by a Bland Altman plot with 95% limits of agreement. 85.6% of patients remained in the same LARS category. The LARS score showed negative correlation with all five of the QLQ-C30 functional scales as well as positive correlation to the diarrhea symptom scale. The questionnaire score differed between patients according to their tumor location, Chemoradiotherapy, type of mesorectal excision and anastomosis. Conclusion: The Arabic version of the LARS score shows good psychometric properties and can be used for bowel dysfunction assessment in clinical and research settings.

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Section: Discussionsupporting

confidence: 73%

Validation of the arabic version of the low anterior resection syndrome score

Essangri

Majbar²,

Benkabbou

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The LARS score is a validated scoring system for bowel dysfunction after low anterior resection for colorectal cancer. The Dutch version was recently validated [23]. This score covers the five most bothersome issues in terms of prevalence and impact of QoL, namely incontinence for flatus and liquid stool, frequency, clustering, and urgency.…”

Section: Lars Scorementioning

confidence: 99%

“…A statistically significant association exists between a higher LARS score and an impaired QoL. The test-retest reliability of the LARS score is good, with an interclass correlation coefficient of 0.79 [23]. Fecal incontinence quality of life score (FIQL score)…”

Section: Lars Scorementioning

confidence: 99%

Pelvic floor rehabilitation to improve functional outcome and quality of life after surgery for rectal cancer: study protocol for a randomized controlled trial (FORCE trial)

Kalkdijk-Dijkstra

Heijden

Westreenen

et al. 2020

Trials

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Background: After low anterior resection (LAR), up to 90% of patients develop anorectal dysfunction. Especially fecal incontinence has a major impact on the physical, psychological, social, and emotional functioning of the patient but also on the Dutch National Healthcare budget with more than €2000 spent per patient per year. No standardized treatment is available to help these patients. Common treatment nowadays is focused on symptom relief, consisting of lifestyle advices and pharmacotherapy with bulking agents or antidiarrheal medication. Another possibility is pelvic floor rehabilitation (PFR), which is one of the most important treatments for fecal incontinence in general, with success rates of 50-80%. No strong evidence is available for the use of PFR after LAR. This study aims to prove a beneficial effect of PFR on fecal incontinence, quality of life, and costs in rectal cancer patients after sphincter-saving surgery compared to standard treatment. Methods: The FORCE trial is a multicenter, two-armed, randomized clinical trial. All patients that underwent LAR are recruited from the participating hospitals and randomized for either standard treatment or a standardized PFR program. A total of 128 patients should be randomized. Optimal blinding is not possible. Stratification will be done in variable blocks (gender and additional radiotherapy). The primary endpoint is the Wexner incontinence score; secondary endpoints are health-related and fecal-incontinence-related QoL and cost-effectiveness. Baseline measurements take place before randomization. The primary endpoint is measured 3 months after the start of the intervention, with a 1-year follow-up for sustainability research purposes. Discussion: The results of this study may substantially improve postoperative care for patients with fecal incontinence or anorectal dysfunction after LAR. This section provides insight in the decisions that were made in the organization of this trial.

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“…To date, a multitude of translation and validation studies have proven this tool to be both valid and reliable in different languages, countries and cultural contexts, yet the LARS score has never been translated into Arabic. [8][9][10][11][12][13][14][15][16][17] In Arabic speaking countries, colloquial Arabic varies between regions, with spoken versions being different from the Modern Standard Arabic and not always being mutually comprehensible [18]. The aim of this study is to translate the LARS score into Moroccan Arabic and to test its psychometric properties in Moroccan rectal cancer patients in order to allow its use as a low anterior resection syndrome assessment tool in clinical practice and future research.…”

Section: Introductionmentioning

confidence: 99%

Validation of the Moroccan arabic version of the low anterior resection syndrome score

Essangri¹,

Majbar²,

Benkabbou³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome. The aim of this observational study is to translate this tool into arabic and test its psychometric properties in rectal cancer patients, in order to ease its use in clinical practice and future research.Methods: The LARS questionnaire was translated to arabic and administered to a total of 143 patients. A subgroup of 42 patients took the test twice for test-retest reliability. Internal consistency was examined through cronbach’s alpha. The score results were correlated to the EORTC QLQ-C30 questionnaire for convergent validity assessment, while discriminant validity was established through the ability of the LARS score to differentiate patients with different clinical and pathological criteria.Results: The Moroccan Arabic version of the LARS score was completed by 143 patients. The internal consistency was demonstrated through a cronbach alpha score of 0.66. The agreement between the test and retest was established by a Bland Altman plot with 95% limits of agreement. 85.6% of patients remained in the same LARS category. The LARS score showed negative correlation with all five of the QLQ-C30 functional scales as well as positive correlation to the diarrhea symptom scale. The questionnaire score differed between patients according to their tumor location, chemoradiotherapy, type of mesorectal excision and anastomosis. Conclusion: The Moroccan Arabic version of the LARS score shows good psychometric properties and can be used for bowel dysfunction assessment in clinical and research settings.

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Dutch validation of the low anterior resection syndrome score

Abstract: The good psychometric properties of the Dutch version of the LARS score are comparable overall to the earlier validations in other countries. Therefore, the Dutch translation can be considered to be a valid tool for assessing LARS in Dutch rectal cancer patients.

Cited by 40 publications

References 21 publications

Validation of the arabic version of the low anterior resection syndrome score

Validation of the arabic version of the low anterior resection syndrome score

Pelvic floor rehabilitation to improve functional outcome and quality of life after surgery for rectal cancer: study protocol for a randomized controlled trial (FORCE trial)

Validation of the Moroccan arabic version of the low anterior resection syndrome score

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