Duyun compound green tea extracts regulate bile acid metabolism on mice induced by high-fat diet

Zhou, Xiaolu; Li, Yaling; Mu, Ren; Wang, Chuanming; Song, Yuyan; Zhou, Caibi; Mei, Xin

doi:10.1017/s0007114522003166

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Furthermore, previous studies have shown that EGCG can bind to bile acids and alter the structure of mixed micelles composed of bile salts, phospholipids, and cholesterol, thereby reducing cholesterol solubility and potentially impacting lipid absorption. These findings provide insights into how EGCG-bile salt interactions may influence the bioavailability and cellular uptake of EGCG, as well as its effects on lipid metabolism [ 50 , 51 ]. These in vitro results suggest encapsulation of EGCG in WPI- and NaCas-stabilized emulsions can improve its intestinal absorption and bioavailability when administered orally [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Whey Protein Sodium-Caseinate as a Deliverable Vector for EGCG: In Vitro Optimization of Its Bioaccessibility, Bioavailability, and Bioactivity Mode of Actions

Korin,

Gouda,

Youssef

et al. 2024

Molecules

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Epigallocatechin gallate (EGCG), the principal catechin in green tea, exhibits diverse therapeutic properties. However, its clinical efficacy is hindered by poor stability and low bioavailability. This study investigated solid particle-in-oil-in-water (S/O/W) emulsions stabilized by whey protein isolate (WPI) and sodium caseinate (NaCas) as carriers to enhance the bioavailability and intestinal absorption of EGCG. Molecular docking revealed binding interactions between EGCG and these macromolecules. The WPI- and NaCas-stabilized emulsions exhibited high encapsulation efficiencies (>80%) and significantly enhanced the bioaccessibility of EGCG by 64% compared to free EGCG after simulated gastrointestinal digestion. Notably, the NaCas emulsion facilitated higher intestinal permeability of EGCG across Caco-2 monolayers, attributed to the strong intermolecular interactions between caseins and EGCG. Furthermore, the emulsions protected Caco-2 cells against oxidative stress by suppressing intracellular reactive oxygen species generation. These findings demonstrate the potential of WPI- and NaCas-stabilized emulsions as effective delivery systems to improve the bioavailability, stability, and bioactivity of polyphenols like EGCG, enabling their applications in functional foods and nutraceuticals.

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Section: Resultsmentioning

confidence: 99%

Whey Protein Sodium-Caseinate as a Deliverable Vector for EGCG: In Vitro Optimization of Its Bioaccessibility, Bioavailability, and Bioactivity Mode of Actions

Korin,

Gouda,

Youssef

et al. 2024

Molecules

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Matcha alleviates obesity by modulating gut microbiota and its metabolites

Luo,

Wen,

Huang

et al. 2024

Current Research in Food Science

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Effects of different iodine levels on the DNA methylation of intrinsic apoptosis-associated genes and analysis of gene–environment interactions in patients with autoimmune thyroiditis

Zhou

Jin

et al. 2023

Br J Nutr

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Iodine, is an essential nutrient that may change the occurrence of autoimmune thyroiditis (AIT). Apoptosis and DNA methylation participate in the pathogenesis and destructive mechanism of AIT. We detected the methylation and the expression of mRNA of intrinsic apoptosis-associated genes (YWHAG, ING4, BRSK2, and GJA1) to identify the potential interactions between the levels of methylation in these genes and different levels of iodine. 176 adult patients with AIT in Shandong Province, China, were included. The MethylTargetTM assay was used to verify the levels of methylation. We used PCR to detect the mRNA levels of the candidate genes. Interactions between methylation levels of the candidate genes and iodine levels were evaluated with multiplicative and addictive interaction models and GMDR. In the AIT group, YWHAG_1 and six CpG sites, and BRSK2_1 and eight CpG sites were hypermethylated, whereas ING4_1 and one CpG site were hypomethylated. A negative correlation was found between methylation levels of YWHAG and mRNA expression. The combination of iodine fortification, YWHAG_1 hypermethylation, and BRSK2_1 hypermethylation was significantly associated with elevated AIT risk. A four-locus model (YWHAG_1×ING4_1×BRSK2_1×iodine level) was found to be the best model of the gene-environment interactions. We identified abnormal changes in the methylation status of YWHAG, ING4, and BRSK2 in patients with AIT in different iodine levels. Iodine fortification not only affected the methylation levels of YWHAG and BRSK2 but also interacted with the methylation levels of these genes and may ultimately increase the risk of AIT.

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Duyun compound green tea extracts regulate bile acid metabolism on mice induced by high-fat diet

Cited by 3 publications

References 37 publications

Whey Protein Sodium-Caseinate as a Deliverable Vector for EGCG: In Vitro Optimization of Its Bioaccessibility, Bioavailability, and Bioactivity Mode of Actions

Whey Protein Sodium-Caseinate as a Deliverable Vector for EGCG: In Vitro Optimization of Its Bioaccessibility, Bioavailability, and Bioactivity Mode of Actions

Matcha alleviates obesity by modulating gut microbiota and its metabolites

Effects of different iodine levels on the DNA methylation of intrinsic apoptosis-associated genes and analysis of gene–environment interactions in patients with autoimmune thyroiditis

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