The paper presents a performance analysis of low power CMOS Integrated "Voltage Differencing Buffered Amplifier Ion Sensitive Field Effect Transistor" (VDBA-ISFET). The main focus is on simulation of power and performance analysis along with the comparison with existing devices, which is used for water quality monitoring. This approach can improve the calibration of device to a fairly wide range without the use of a high speed digital processor. The conventional devices generally used consume high power and are not stable for long term monitoring. The conventional device has a drawback of low value of slew rate, high power consumption, and non linear characteristics but in this novel design, the device exhibits a better slew rate, piece-wise linear characteristics, and seen consuming low power of the order of 11.3µW. The functionality of the circuit is tested using Tanner simulator version 15 for CMOS process model. The proposed circuit reduces total power consumption per cycle, increases speed of operation, fairly linear and is simple to implement.This device has a simple architecture, and hence is very suitable for water quality monitoring applications.