DXA-based hip structural analysis of once-weekly bisphosphonate-treated postmenopausal women with low bone mass

Bonnick, Sydney Lou; Beck, Thomas; Cosman, Felicia; Hochberg, Marc C.; Wang, H.; Papp, Anne E. de

doi:10.1007/s00198-008-0762-4

Cited by 38 publications

(20 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HSA parameters included CTh, endosteal and outer (i.e., subperiosteal) diameters, cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), section modulus (Z), and buckling ratio (BR). The CSA is the total mineralized bone surface area in the cross-section and excludes marrow and soft tissue voids [22,23]; it has been observed to be highly correlated to DXA BMC, as expected because its equation is related to DXA BMC by a constant factor [24]. The CSMI describes the distribution of bone mass about the neutral axis of bending [12], and Z defines the maximum bending stress [22].…”

Section: Methodsmentioning

confidence: 99%

Effect of monthly ibandronate on hip structural geometry in men with low bone density

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Effect of monthly ibandronate on hip structural geometry in men with low bone density

et al. 2011

View full text Add to dashboard Cite

show abstract

“…According to the previous DXA-based HSA studies that analyzed the effects of anti-osteoporosis drugs on the geometry [14][15][16] , distinct effects on the femoral neck and shaft were observed. In the current study using non-invasive CT scanning of the proximal femur, all of the biomechanical parameters, CSMI, SM and BR, worsened significantly with advancing age in the femoral neck, while those in the femoral shaft did not change.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in bone density, geometry and biomechanical properties of the proximal femur: CT-based 3D hip structure analysis in normal postmenopausal women

Ito

Nakata

Nishida

et al. 2011

Bone

View full text Add to dashboard Cite

The geometry as well as bone mineral density (BMD) of the proximal femur contributes to fracture risk. How and the extent to which they change due to natural aging is not fully understood.We assessed BMD and geometry in the femoral neck and shaft separately, in 59 normal Japanese postmenopausal women aged 54 to 84 years, using clinical computed tomography (CT) and commercially available software, at baseline and 2 year follow up.This system detected significant reductions over the 2-year interval in total BMD (%change/year=-0.900±0.257, p<0.0005), cortical cross-sectional area (CSA) (-0.800±0.423 %/year, p<0.05) and cortical thickness (-1.120± 0.453 %/year, p<0.01) in the femoral neck. In the femoral shaft, cortical BMD decreased significantly (-0.642± 0.188 %/year, p<0.005). Regarding biomechanical parameters in the femoral neck, the cross-sectional moment of inertia (CSMI) and section modulus (SM) decreased (-1.38± 3.65 %/year, p<0.01 and -1.37± 2.96 %/year, p<0.005) and the buckling ratio (BR) increased significantly (1.48± 4.81 %/year, p<0.05), whereas no changes were found in the femoral shaft.The distinct patterns of age-related changes in the geometry and biomechanical properties in the femoral neck and shaft suggest that improved geometric measures are possible with the current 3 non-invasive method using clinical CT.

show abstract

“…The hip structure analysis (HSA) is applied to measure proximal femur geometry and strength using DXA. 17,18 The HSA has demonstrated age trends, racial and gender differences, and treatment effects on patients with osteoporosis, [18][19][20][21][22][23][24][25][26] as well as age-related differences in structural geometry and strength of the femur. 27 Raloxifene and bisphosphonates (alendronate, risedronate) have positive effects on the structural geometry of the proximal femur in Japanese women with osteoporosis.…”

mentioning

confidence: 99%

Correlation between a Bone Resorption Marker and Structural Geometry of the Proximal Femur in Osteoporotic Women Treated with Raloxifene

Takada

Iba

Yoshizaki³

et al. 2012

J Orthop Surg (Hong Kong)

View full text Add to dashboard Cite

purpose. To assess correlations between a bone resorption marker and the structural geometry of the proximal femur in raloxifene-treated postmenopausal women with osteoporosis. Methods. 45 postmenopausal, osteoporotic women aged 57 to 79 (mean, 67) years underwent raloxifene treatment (60 mg/day) for 12 months. Serum type-I collagen crosslinked N-telopeptide (sNTX) as the bone resorption marker was measured at baseline and 6 months, whereas hip structure analysis (HSA) parameters of the femur (neck, intertrochanter, and shaft) were measured at baseline and 12 months using dual energy X-ray absorptiometry. The HSA parameters included areal bone mineral density (BMD), inner diameter, mean cortical thickness, crosssectional area, section modulus, and buckling ratio. Correlations between sNTX and HSA parameters were analysed using Pearson's R. results. At baseline, sNTX correlated inversely with BMD, cross-sectional area, mean cortical thickness, Correlation between a bone resorption marker and structural geometry of the proximal femur in osteoporotic women treated with raloxifene

show abstract

DXA-based hip structural analysis of once-weekly bisphosphonate-treated postmenopausal women with low bone mass

Abstract: HSA offers insight into the potential mechanisms of fracture risk reduction from pharmacologic intervention. In the current study, treatment with once-weekly bisphosphonates resulted in significant improvements in hip geometric parameters.

Cited by 38 publications

References 47 publications

Effect of monthly ibandronate on hip structural geometry in men with low bone density

Effect of monthly ibandronate on hip structural geometry in men with low bone density

Age-related changes in bone density, geometry and biomechanical properties of the proximal femur: CT-based 3D hip structure analysis in normal postmenopausal women

Correlation between a Bone Resorption Marker and Structural Geometry of the Proximal Femur in Osteoporotic Women Treated with Raloxifene

Contact Info

Product

Resources

About