Dy-DOTA integrated mesoporous silica nanoparticles as promising ultrahigh field magnetic resonance imaging contrast agents

Zheng, Xiaoyu; Pellico, Juan; Khrapitchev, Alexandr A; Sibson, Nicola R.; Davis, Jason J.

doi:10.1039/c8nr07198e

Cited by 27 publications

(38 citation statements)

References 37 publications

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“…( D ) MRI phantoms characterising the response of the system. Adapted with permission from reference [ 80 ]. Copyright (2018) The Royal Society of Chemistry.…”

Section: Figurementioning

confidence: 99%

Mesoporous Silica Nanoparticles in Bioimaging

2020

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A biomedical contrast agent serves to enhance the visualisation of a specific (potentially targeted) physiological region. In recent years, mesoporous silica nanoparticles (MSNs) have developed as a flexible imaging platform of tuneable size/morphology, abundant surface chemistry, biocompatibility and otherwise useful physiochemical properties. This review discusses MSN structural types and synthetic strategies, as well as methods for surface functionalisation. Recent applications in biomedical imaging are then discussed, with a specific emphasis on magnetic resonance and optical modes together with utility in multimodal imaging.

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“…( D ) MRI phantoms characterising the response of the system. Adapted with permission from reference [ 80 ]. Copyright (2018) The Royal Society of Chemistry.…”

Section: Figurementioning

confidence: 99%

Mesoporous Silica Nanoparticles in Bioimaging

2020

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“…[50] Ar ecent contribution to this research of latter lanthanide(III) CAs includes the integration of Dy III -DOTAm otifs into mesoporous silica NP scaffolds, generating impressive r 2 relaxivities at ultrahigh fields, reaching around 140 s À1 mm À1 . [51] The authors directly ascribed this high relaxivity to the effects of nanoscale confinement (high local paramagnetic density) on accentuated magnetization. [51] Nanoparticle-Based Probes for Bimodal High Field MR and Optical Imaging…”

Section: Supramolecular Probes For Bimodal High-field Mr and Optical mentioning

confidence: 99%

“…[51] The authors directly ascribed this high relaxivity to the effects of nanoscale confinement (high local paramagnetic density) on accentuated magnetization. [51] Nanoparticle-Based Probes for Bimodal High Field MR and Optical Imaging…”

Section: Supramolecular Probes For Bimodal High-field Mr and Optical mentioning

confidence: 99%

High‐Field MRI Contrast Agents and their Synergy with Optical Imaging: the Evolution from Single Molecule Probes towards Nano‐architectures

Harris

Biju²,

Parac-Vogt

2019

Chemistry A European J

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Contrast agents for magnetic resonance imaging have historically been based on paramagnetic metal complexes, particularly Gd3+ chelates, which tend to lose their contrast enhancement ability with increasing magnetic field strength. Emerging high‐field MRI applications require the development of novel contrast agents that exhibit high relaxation enhancement as a function of magnetic field strength. Paramagnetic ions such as Dy3+, Tb3+ or Ho3+ incorporated into supramolecular or inorganic nano‐architectures represent promising platforms for the development of high field MRI contrast agents. Furthermore, such platforms allow facile inclusion of multiple imaging modalities, therapeutic loading, and targeting vectors. This Minireview examines the application of contrast agents for high‐field MRI, which range from single molecules to nanoparticles. Approaches to create multimodal agents by combining high‐field MRI contrast properties with another imaging modality are also discussed.

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“…10). Mesoporous silica NPs are also used as promising [115][116][117][118] ultrahigh field MRI imaging contrast agents.…”

Section: Nps For Clinical Imaging Technologiesmentioning

confidence: 99%

Nanoparticles in Biomedicine-Focus on Imaging Applications

Zhou¹,

Wang²,

Du³

et al. 2018

Eng. Sci.

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Over the last two decades, nanotechnology has become one of the most dynamically evolving field of research. Various types of nanoparticles are widely exploited to extend our understanding of biological interactions at the molecular level. They are actively engaged in the biomedical research for imaging, biosensing, drug delivery and/or concurrent therapy. Recent progress on this field is briefly reviewed here with an emphasis placed on the wide imaging applications of nanoparticles. Collectively, this field will no doubt make greater impact after we gradually address any potential risks of nanoparticles.

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Dy-DOTA integrated mesoporous silica nanoparticles as promising ultrahigh field magnetic resonance imaging contrast agents

Abstract: Integrating Dy-DOTA motifs into mesoporous silica nanoparticle scaffolds significantly amplifies the ultrahigh field T2 relaxivity via a Curie outer-sphere mechanism.

Cited by 27 publications

References 37 publications

Mesoporous Silica Nanoparticles in Bioimaging

Mesoporous Silica Nanoparticles in Bioimaging

High‐Field MRI Contrast Agents and their Synergy with Optical Imaging: the Evolution from Single Molecule Probes towards Nano‐architectures

Nanoparticles in Biomedicine-Focus on Imaging Applications

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