Dydrogesterone<i>vs</i>progesterone for luteal-phase support: systematic review and meta-analysis of randomized controlled trials

Barbosa, Marina W. P.; Silva, Lívia R.; Navarro, Paula Andrea; Ferriani, Rui Alberto; Nastri, C.O.; Martins, W.P.

doi:10.1002/uog.15814

Cited by 54 publications

(34 citation statements)

References 39 publications

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“…Where a significant difference was observed, we determined the number needed to treat for an additional beneficial (NNTB) or harmful (NNTH) outcome. The random-effects model was chosen because the true effect size should not be assumed to be the same across studies; additionally, the random-effects model incorporates the observed heterogeneity among studies, obtaining more conservative CIs [14][15][16] . Heterogeneity was assessed by the I 2 statistic; wherever it was moderate (I 2 > 30%) or substantial (I 2 > 50%), we explored the possible explanations by conducting subgroup analyses, sensitivity analyses and cumulative meta-analyses.…”

Section: Summary Measures and Synthesis Of Resultsmentioning

confidence: 99%

Blastocyst vs cleavage‐stage embryo transfer: systematic review and meta‐analysis of reproductive outcomes

Martins

Nastri²,

Rienzi

et al. 2017

Ultrasound in Obstet & Gyne

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119

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Objectives (RR, 1.10 (95% CI,12 Correspondence to: Prof. W. P. Martins, SEMEAR Fertilidade, Av Aurea Apparecida Braghetto Machado, 220 Ribeirão Preto -SP, 14021-460 Brazil (e-mail: wpmartins@gmail.com) Accepted: 4 October 2016RCTs, 2418 women, I 2 = 64%), cumulative pregnancy (RR, 0.89 (95% CI,), four RCTs, 524 women, I 2 = 63%) and miscarriage (RR, 1.08 (95% CI,, 10 RCTs, 763 pregnancies, I 2 = 0%). There was moderate-quality evidence of a decrease in the number of women with surplus embryos after the blastocyst-stage embryo transfer (RR, 0.78 (95% CI,

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Section: Summary Measures and Synthesis Of Resultsmentioning

confidence: 99%

Blastocyst vs cleavage‐stage embryo transfer: systematic review and meta‐analysis of reproductive outcomes

Martins

Nastri²,

Rienzi

et al. 2017

Ultrasound in Obstet & Gyne

Self Cite

119

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“…In a randomized study, a lower risk of preterm birth was associated with oral micronized progesterone than placebo [ 27 ]. Additionally, in a recent meta-analysis, oral dydrogesterone was as effective as vaginal progesterone for luteal phase support in assisted reproduction [ 28 ]. It has also been reported that intramuscular progesterone administration is associated with implantation, clinical pregnancy, and delivery rates that are comparable to those resulting from treatment with vaginal progesterone during stimulated IVF cycles [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Oral Dydrogesterone and Vaginal Progesterone on Threatened Abortion: A Systematic Review and Meta-Analysis

Lee

Park

Kim

et al. 2017

BioMed Research International

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Objective To conduct systematic analyses to evaluate the efficacy of progesterone therapy for the prevention of miscarriages in pregnant women experiencing threatened abortion. Methods In November 2016, we performed a systematic literature search and identified 51 articles in PubMed, Embase, and Cochrane databases. We identified nine randomized trials that included 913 pregnant women (including 322 treated with oral dydrogesterone, 213 treated with vaginal progesterone, and 378 control subjects) who met the selection criteria. Results The incidence of miscarriage was significantly lower in the total progesterone group than in the control group (13.0% versus 21.7%; odds ratio, 0.53; 95% confidence interval (CI), 0.36 to 0.78; P = 0.001; I2, 0%). Moreover, the incidence of miscarriage was significantly lower in the oral dydrogesterone group than in the control group (11.7% versus 22.6%; odds ratio, 0.43; 95% CI, 0.26 to 0.71; P = 0.001; I2, 0%) and was lower in the vaginal progesterone group than in the control group, although this difference was nonsignificant (15.4% versus 20.3%; odds ratio, 0.72; 95% CI, 0.39 to 1.34; P = 0.30; I2, 0%). However, the incidence of miscarriage was not different between the oral dydrogesterone and vaginal progesterone groups. Conclusion Progesterone therapy, especially oral dydrogesterone, can effectively prevent miscarriage in pregnant women experiencing threatened abortion.

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“…In terms of route of administration, progesterone used as LPS in our study was oral Dydrogesterone (10 mg twice daily). This route of use in the study was supported by systematic review and meta-analysis of RCT done by Barbosa et al who ended up in a conclusion that the use of oral dydrogesterone seems to be as effective as vaginal progesterone for LPS in ART cycles and appears to be better tolerated [21]; furthermore, oral route efficacy confirmed in IVF by Phase III-RCT that compares the efficacy, safety, and tolerability of oral dydrogesterone versus micronized vaginal progesterone for LPS [22]. Similar reports on equivalent efficacy were documented from RCTs in Iran and India [23,24].…”

Section: Discussionmentioning

confidence: 80%

Pregnancy Rate Following Luteal Phase Support in Polycystic Ovary Women Using Letrozole With or Without Gonadotropin as Ovulation Induction

Alizzi

2018

Asian J Pharm Clin Res

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Objective: The objective of the study was to evaluate the effect of luteal phase progesterone supplementation on pregnancy rates in anovulatory infertile polycystic ovary women using letrozole with or without gonadotropin as ovulation induction (OI).Method: A prospective randomized clinical study conducted in the infertility clinic - Al-Yarmouk Teaching Hospital, Baghdad/Iraq from June 2016 to January 2018. A total of 149 infertile polycystic ovary women who achieved ovulation using letrozole alone or with gonadotropin as OI protocol enrolled. Accordingly, the study group divided into two: Group A (letrozole group, no=99) and Group B (letrozole gonadotropin group, no=50). After triggering with human Chorionic Gonadotropin, the women in each group were randomly divided into two subgroup women with luteal phase support (LPS) and women without. The primary outcome measure was pregnancy rate.Results: The study shows that pregnancy rate was higher with letrozole group using LPS although the difference did not reach statistical significant (p=0.08). After adjustment of possible confounders; patients receiving letrozole with gonadotropin with LPS had significantly higher successful pregnancy rate.Conclusion: Administration of LPS after OI in infertile polycystic ovarian syndrome women may improve pregnancy rate.

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Dydrogesteronevsprogesterone for luteal-phase support: systematic review and meta-analysis of randomized controlled trials

Abstract: Objectives To compare the effects of dydrogesterone and progesterone for luteal-phase support (LPS) in women undergoing assisted reproductive techniques (ART). Methods

Cited by 54 publications

References 39 publications

Blastocyst vs cleavage‐stage embryo transfer: systematic review and meta‐analysis of reproductive outcomes

Blastocyst vs cleavage‐stage embryo transfer: systematic review and meta‐analysis of reproductive outcomes

The Influence of Oral Dydrogesterone and Vaginal Progesterone on Threatened Abortion: A Systematic Review and Meta-Analysis

Pregnancy Rate Following Luteal Phase Support in Polycystic Ovary Women Using Letrozole With or Without Gonadotropin as Ovulation Induction

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