Dye Dilution Curves and Cardiac Output in Newborn Infants

Prec, Klara J.; Cassels, Donald E.

doi:10.1161/01.cir.11.5.789

Cited by 52 publications

(20 citation statements)

References 12 publications

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“…They deduced that there was in these infants a right-left shunt, probably through a patent ductus arteriosus. Prec & Cassels (1955) found that a large proportion of infants less than 15 hr old showed abnormal dye dilution curves after injection of T-1824 into the umbilical vein. These were attributed to persistent patency of the ductus arteriosus.…”

Section: Discussionmentioning

confidence: 98%

The constriction of the ductus arteriosus caused by oxygen and by asphyxia in newborn lambs

Born¹,

Dawes²,

Mott³

et al. 1956

The Journal of Physiology

163

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Section: Discussionmentioning

confidence: 98%

The constriction of the ductus arteriosus caused by oxygen and by asphyxia in newborn lambs

Born¹,

Dawes²,

Mott³

et al. 1956

The Journal of Physiology

163

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“…Values for cardiac index in newborn infants range from 2.5 to 4.0 liters/min/m 2 [11,26]; in the adult the average value for cardiac index is 3.12 liters/min/m 2 [7]. Mean systemic arterial pressure increases from approximately 60 to 70 mm Hg [20,34] in the immediate newborn period, to 100 mm Hg at puberty [12].…”

Section: Age-related Changes In Rbf In Human Infantsmentioning

confidence: 99%

Maturational Changes in Renal Blood Flow in Piglets

1970

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ExtractCardiac output, renal blood flow, and intrinsic renal vascular resistance were measured in piglets ranging in age from 6 h to 45 days. During this period of time the mean cardiac output increased from 0.9 to 6.5 liters/min/m . These data demonstrate that the large increase in renal blood flow in the pig during the first 6 weeks of life was due to both an increase in cardiac output as well as a decrease in renal vascular resistance. By 6 weeks of age, cardiac output was at adult levels. Since in the adult pig the kidney receives 20 % of the cardiac output, increases in renal blood flow beyond 6 weeks of age must result from further decreases in renal vascular resistance. SpeculationIn the human infant, cardiac index is comparable to values observed in the adult. It appears, therefore, that the entire increase in renal blood flow observed during year 1 of life is due to steadily decreasing renal vascular resistance. Since glomerular filtration rate is modified by the relative resistances in the glomerular afferent and efferent arterioles, the parallel increases in filtration rate during infancy may be related to the same mechanism.Introduction mates renal plasma flow by not more than 30-40%. Rates of flow reach mature levels (1,200 ml/min/1.73 Numerous studies have shown that renal blood flow m

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“…This is mainly becauise only those metho(ds wlhichi require no active cooperationi on the part of' the suibject can be applied to inf:aints. Moreover, there is an additional problem in obtaining reliable data dturing the early neonatal period, since there is conisiderable evidence to stuggest that many healthfy newborni infants, especially those born premncatuirely, continue to have some left to right slhuint dturing at least the 1st wk of life (8)(9)(10)(11). This wouild restult in rapid recirctulation, distturbing the uiptake of soluble inert gases and thereby cauising Qc eff' to be tunderestimiiated.…”

Section: Introductionmentioning

confidence: 99%