Dye-guided sentinel lymphadenectomy in clinically node-positive and node-negative breast cancer patients

Noguchi, Masakuni; Tsugawa, Koichiro; Kawahara, Futoshi; Bando, Etsuro; Miwa, Koichi

doi:10.1016/s0959-8049(98)80195-0

Cited by 4 publications

(6 citation statements)

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“…Many investigators have reported results obtained with lymphatic mapping and sentinel lymph node biopsy in patients with breast carcinoma. Currently, staining with blue dye, radiocolloid, or both is used for sentinel lymph node biopsy in these patients, yielding detection rates ranging from 66% to 98%,7–14 from 82% to 98%,15–22 and from 90% to 96%, respectively 23–29. Generally, radiocolloid localization appears to detect sentinel lymph nodes more frequently than vital blue dye.…”

Section: Discussionmentioning

confidence: 99%

“…In 1996, Albertini et al1 reported a combined procedure using both of these agents. Since these reports, there have been many studies of lymphatic mapping and sentinel lymph node biopsy in breast carcinoma 8–29. More detailed evaluation of sentinel lymph nodes using serial sectioning or cytokeratin (CK) immunohistochemistry has improved the staging accuracy of sentinel lymph node biopsy 8, 9, 22, 27–29.…”

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confidence: 99%

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Sentinel lymph nodes with technetium‐99m colloidal rhenium sulfide in patients with esophageal carcinoma

Kato

Miyazaki

Nakajima

et al. 2003

Cancer

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BACKGROUND The authors assessed the detection of sentinel lymph nodes in patients with esophageal squamous cell carcinoma (SCC) using technetium‐99m colloidal rhenium sulfide. They studied whether an analysis of sentinel lymph nodes using cytokeratin (CK) immunohistochemistry increased the accuracy of staging. METHODS The authors observed 25 patients with thoracic esophageal carcinomas who underwent radical esophagectomy. The day before surgery, technetium‐99m colloidal rhenium sulfide was injected into the submucosa at four sites around the primary tumor. Lymphoscintigraphy was performed. Esophagectomy and regional lymph node dissection were performed 17 hours after the technetium‐99m injection. After surgery, the resected lymph nodes were evaluated by CK staining. RESULTS Lymphoscintigraphy detected sentinel lymph nodes in 92% of the patients (23 of 25 patients). The accuracy of sentinel lymph node was 91.3% (21 of 23 patients), the sensitivity was 86.7% (13 of 15 patients), and the false‐negative rate was 8.7% (2 of 23 patients). A comparison of the number of sentinel lymph nodes and clinicopathologic factors showed that there was a significant association between the number of sentinel lymph nodes and lymph node status (P < 0.01), pathologic stage (P < 0.05), and the number of metastatic lymph nodes (P < 0.05). Occult metastasis was detected by CK staining in 14 (56%) of the 25 patients and in 23 (1.7%) of 1406 lymph nodes. Because the 2 false‐negative (sentinel lymph node–negative and nonsentinel lymph node–positive) patients who had occult metastases in the sentinel lymph nodes, the accuracy of sentinel lymph node evaluation using CK staining was 100% (23 of 23). CONCLUSIONS Lymphatic mapping with technetium‐99m colloidal rhenium sulfide was used to identify the lymphatic basin and was feasible in patients with esophageal SCC. An analysis of sentinel lymph nodes using CK immunohistochemistry increased the accuracy of sentinel lymph node. Cancer 2003;98:932–9. © 2003 American Cancer Society. DOI 10.1002/cncr.11559

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Sentinel lymph nodes with technetium‐99m colloidal rhenium sulfide in patients with esophageal carcinoma

Kato

Miyazaki

Nakajima

et al. 2003

Cancer

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“…The lateral lymph node, which was the original sentinel lymph node for the thumb area, was occupied by tumor cells; the lymph flow changed and the blue staining decreased. The subscapular lymph node was thus recognized as the sentinel lymph node in our case: the original sentinel lymph node was not dyed, and the lymph channels which were dyed flowed to the gate of the node in cases of severe metastasis (5, 7). This suggests that cases with metastasis in several lymph nodes have a lower detection rate in the original sentinel lymph nodes because of the change in lymph flow, as in our case.…”

Section: Discussionmentioning

confidence: 87%

Sentinel Lymph Nodes Study in 30 Cases of Melanoma

Ishihara

Nakamura

Kageshita

et al. 2001

The Journal of Dermatology

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In 30 cases of melanoma, we attempted to detect sentinel lymph nodes using 1-2% patent blue dye and were able to detect them in 27 cases (90%): 19 cases out of 21 cases in the groin area (90%), 5 out of 5 cases in the axilla area (100%), and 3 out of 4 cases in the neck area (75%). The numbers of sentinel lymph nodes were one in 16 cases, two in 7 cases, three in 2 cases, and four in 2 cases. The cases with three and four nodes were all in the groin area. In 22 cases, tumor metastasis was negative in sentinel lymph nodes. Sentinel lymph nodes were detected in 36 out of 174 samples, and tumor metastasis was negative except in these sentinel lymph nodes (false negative 0%). In the groin area, sentinel lymph nodes were located around the femoral and great saphenous vein junction. In the axilla area, sentinel lymph nodes were located in the central, lateral and subscapular lymph nodes. In the head and neck area, sentinel lymph nodes were found in the submandibular and occipital lymph nodes. The positions of sentinel lymph nodes differed a little with tumor location. By accumulating cases, it should become possible to predict the positions of sentinel lymph nodes before operations. Sentinel lymph node biopsy is easy and requires only a small incision.

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“…[1][2][3] The current standard of care to evaluate the status of axillary metastasis is sentinel lymph node biopsy (SLNB). 2,4 In the presence of a positive sentinel lymph node (SLN), the standard of care is to perform a complete axillary dissection, usually during a second operation which is often associated with increased morbidity and cost, as intraoperative frozen section analysis is often inaccurate in determining the presence of metastasis in axillary lymph nodes. 2,5 US and MRI are two modalities often used in the treatment of breast cancer patients, particularly in the pre-operative setting.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Accuracy of Ultrasound Compared to Magnetic Resonance Imaging in the Ability to Detect Metastatic Breast Cancer to the Axilla

Ramirez

Scholle

Buckmaster

et al. 2012

Surgical Techniques Development

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Sentinel lymph node biopsy (SLNB) is routinely used in the staging of invasive breast cancer. The aim of this study was to investigate the diagnostic accuracy of ultrasonography (US) compared to magnetic resonance imaging (MRI) in the pre-operative assessment of metastatic disease to the axilla in breast cancer patients at our community hospital. We retrospectively reviewed a prospectively collected database of 277 patients seen at our breast center from 2009 to 2010. Patients with invasive breast cancer were then evaluated for axillary metastasis. Lymph nodes were sampled using fine needle aspiration (FNAB) or core biopsy. Histopathology of the sentinel lymph nodes (SLN) or results of the axillary dissection were compared to US or MRI results. A total of 228 patients had invasive breast cancer. In these patients, 122 lymph nodes were sampled. Pathology proven metastases to axillary lymph nodes were found in 76 cases. Accuracy and sensitivity were higher in US than MRI in detecting metastatic disease to the axilla (70.2%, 84.6%, P<0.001 and 60.0%, 52.6%, P <0.1, respectively). US was more accurate than MRI at detecting metastatic breast cancer in the axilla in our community hospital. Axillary US should be a routine part of assessment of breast cancer patients

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Dye-guided sentinel lymphadenectomy in clinically node-positive and node-negative breast cancer patients

Cited by 4 publications

References 0 publications

Sentinel lymph nodes with technetium‐99m colloidal rhenium sulfide in patients with esophageal carcinoma

Sentinel lymph nodes with technetium‐99m colloidal rhenium sulfide in patients with esophageal carcinoma

Sentinel Lymph Nodes Study in 30 Cases of Melanoma

Assessment of the Accuracy of Ultrasound Compared to Magnetic Resonance Imaging in the Ability to Detect Metastatic Breast Cancer to the Axilla

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