“…Black, 2012;Raggi et al, 2007). Withdrawal and depression can further complicate the patient's situation and make intervention attempts more difficult as the disease advances (Appleby, Roy, Valenti, & Lee, 2007;Onor et al, 2007;Tsuno & Homma, 2009;Williams & Tappen, 2007Wood, Womack, & Hooper, 2009). …”