Dynamic Aging: Channeled Through Microenvironment

Tan, Qing‐Qing; Liang, Na; Zhang, Xiaoqian; Li, Jun

doi:10.3389/fphys.2021.702276

Cited by 15 publications

(8 citation statements)

References 214 publications

(241 reference statements)

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“…Cell surface CD38 depletes extracellular levels of NAD(P)H, which has pronounced effects on the microenvironment by affecting the availability of metabolic and signaling molecules. 43, 44 . In addition, cells that express CD38 can influence cell localization and motility through homotypic interactions with other CD38-expressing cells and CD31 on ECs.…”

Section: Resultsmentioning

confidence: 99%

Dysregulated CD38 expression in blood and skin immune cells of patients with hidradenitis suppurativa

Dimitrion

Hamzavi

Yin

et al. 2023

Preprint

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Background: Hidradenitis suppurativa (HS) is a multifactorial, inflammatory skin disease. Increased systemic inflammatory comorbidities and serum cytokines highlight systemic inflammation as a feature of HS. However, the specific immune cell subsets contributing to systemic and cutaneous inflammation have not been resolved. Objective: Identify features of peripheral and cutaneous immune dysregulation. Methods: Here, we generated whole-blood immunomes by mass cytometry. We performed a meta-analysis of RNA-seq data, immunohistochemistry, and imaging mass cytometry to characterize the immunological landscape of skin lesions and perilesions from patients with HS. Results: Blood from patients with HS exhibited lower frequencies of natural killer cells, dendritic cells, and classical (CD14+CD16-) and nonclassical (CD14-CD16+) monocytes, as well as higher frequencies of Th17 cells and intermediate (CD14+CD16+) monocytes than blood from healthy controls. Classical and intermediate monocytes from patients with HS had increased expression of skin-homing chemokine receptors. Furthermore, we identified a CD38+ intermediate monocyte subpopulation that was more abundant in the immunome of blood from patients with HS. Meta-analysis of RNA-seq data found higher CD38 expression in lesional HS skin than in perilesional skin, and markers of classical monocyte infiltration. Imaging mass cytometry showed that CD38+ classical monocytes and CD38+ monocyte-derived macrophages were more abundant in lesional HS skin. Conclusion: Circulating and cutaneous immune cells in patients with HS harbor dysregulated expression of CD38.

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Section: Resultsmentioning

confidence: 99%

Dysregulated CD38 expression in blood and skin immune cells of patients with hidradenitis suppurativa

Dimitrion

Hamzavi

Yin

et al. 2023

Preprint

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“…The secretory profile is constantly influenced by intrinsic characteristics, which depend on the cell type and its differentiation stage, as well as extrinsic factors such as the change in the cellular environment. Indeed, a clear remodeling of the secretory profile can be observed in cells undergoing senescence [ 58 ]. Examining the secretome of senescent cells reveals modifications in the levels of soluble, insoluble, and extracellular vesicle (EV)-related components.…”

Section: Characteristics Of Saspmentioning

confidence: 99%

Exploring the Communication of the SASP: Dynamic, Interactive, and Adaptive Effects on the Microenvironment

Giroud

Bouriez

Paulus

et al. 2023

IJMS

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Cellular senescence is a complex cell state that can occur during physiological ageing or after exposure to stress signals, regardless of age. It is a dynamic process that continuously evolves in a context-dependent manner. Senescent cells interact with their microenvironment by producing a heterogenous and plastic secretome referred to as the senescence-associated secretory phenotype (SASP). Hence, understanding the cross-talk between SASP and the microenvironment can be challenging due to the complexity of signal exchanges. In this review, we first aim to update the definition of senescence and its associated biomarkers from its discovery to the present day. We detail the regulatory mechanisms involved in the expression of SASP at multiple levels and develop how SASP can orchestrate microenvironment modifications, by focusing on extracellular matrix modifications, neighboring cells’ fate, and intercellular communications. We present hypotheses on how these microenvironmental events may affect dynamic changes in SASP composition in return. Finally, we discuss the various existing approaches to targeting SASP and clarify what is currently known about the biological effects of these modified SASPs on the cellular environment.

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“…Cell surface CD38 depletes extracellular levels of NAD(P)H, which has pronounced effects on the microenvironment by affecting the availability of metabolic and signaling molecules. [43,44]. In addition, cells that express CD38 can in uence cell localization and motility through homotypic interactions with other CD38-expressing cells and CD31 on ECs.…”

Section: Lesional Endothelial Cells Express Cd38 and Cmonos Localize ...mentioning

confidence: 99%

Dysregulated CD38 expression in blood and skin immune cells of patients with hidradenitis suppurativa

Dimitrion²,

Hamzavi

et al. 2023

Preprint

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) is a multifactorial, inflammatory skin disease. Increased systemic inflammatory comorbidities and serum cytokines highlight systemic inflammation as a feature of HS. However, the specific immune cell subsets contributing to systemic and cutaneous inflammation have not been resolved. Here, we generated whole-blood immunomes by mass cytometry. We performed a meta-analysis of RNA-seq data, immunohistochemistry, and imaging mass cytometry to characterize the immunological landscape of skin lesions and perilesions from patients with HS. Blood from patients with HS exhibited lower frequencies of natural killer cells, dendritic cells, and classical (CD14+CD16-) and nonclassical (CD14-CD16+) monocytes, as well as higher frequencies of Th17 cells and intermediate (CD14+CD16+) monocytes than blood from healthy controls. Classical and intermediate monocytes from patients with HS had increased expression of skin-homing chemokine receptors. Furthermore, we identified a CD38+ intermediate monocyte subpopulation that was more abundant in the immunome of blood from patients with HS. Meta-analysis of RNA-seq data found higher CD38 expression in lesional HS skin than in perilesional skin, and markers of classical monocyte infiltration. Imaging mass cytometry showed that CD38+ classical monocytes and CD38+ monocyte-derived macrophages were more abundant in lesional HS skin. Overall, we report targeting CD38 may be worth pursuing in clinical trials.

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Dynamic Aging: Channeled Through Microenvironment

Cited by 15 publications

References 214 publications

Dysregulated CD38 expression in blood and skin immune cells of patients with hidradenitis suppurativa

Dysregulated CD38 expression in blood and skin immune cells of patients with hidradenitis suppurativa

Exploring the Communication of the SASP: Dynamic, Interactive, and Adaptive Effects on the Microenvironment

Dysregulated CD38 expression in blood and skin immune cells of patients with hidradenitis suppurativa

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