Dynamic Alterations in Growth Hormone Receptor mRNA Levels in Rat Brain During Stress Tolerance.

Fujikawa, Takahiko; Yoshizato, Hideo; Soya, Hideaki; Nakashima, Kenichiro

doi:10.1507/endocrj.43.suppl_s119

Endocr J

1996

DOI: 10.1507/endocrj.43.suppl_s119

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Dynamic Alterations in Growth Hormone Receptor mRNA Levels in Rat Brain During Stress Tolerance.

Takahiko Fujikawa

Hideo Yoshizato

Hideaki Soya

et al.

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Cited by 4 publications

(2 citation statements)

References 14 publications

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“…The riboprobe of GH receptor mRNA was complementary to 152 bp of a common extracellular region to GH-binding protein and GH receptor mRNAs, and to 120 bp of GH-binding protein mRNA specific hydrophilic tail. Thus a 272 bp fragment of the hybridization between the riboprobe and GH-binding protein mRNA as well as a 152 bp fragment of hybridization between the riboprobe and GH receptor mRNA were yielded as described by Fujikawa et al [23]. Total RNA (40 g) from the muscle was suspended in 30 l hybridization buffer containing excess riboprobe.…”

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confidence: 99%

Local Changes of IGF-I mRNA, GH Receptor mRNA, and Fiber Size in Rat Plantaris Muscle Following Compensatory Overload.

Yamaguchi

Ikeda²,

Hirai³

et al. 2003

JJP

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Skeletal muscle is hypertrophied by compensatory overload [1][2][3]. The magnitude of the hypertrophy after compensatory overload is different between the regions in a rodent muscle [4]. In humans, region-specific hypertrophy exists in consecutive cross-sectional areas of the elbow flexors [5]. Region-specific hypertrophy in a muscle is related to the different muscle fiber recruitment pattern [6,7]. However, what causes region-specific hypertrophy is unclear.Many studies have shown that growth hormone Japanese Journal of Physiology, 53, 53-60, 2003 Key words: IGF-I, GH receptor, hypertrophy, hypophysectomy, muscle fiber. Abstract:We investigated whether local insulin-like growth factor-I (IGF-I) mRNA and growth hormone (GH) receptor mRNA expressions in plantaris muscle were related to the region-specific hypertrophy following compensatory overload. Adult male normal or hypophysectomized rats were subjected to unilateral distal-half removals of the gastrocnemius and soleus muscles. The contralateral hindlimb was used as the control. Two weeks later, fiber areas in the distal and proximal parts of the plantaris muscle were measured. All the fiber areas measured in the distal part of the plantaris muscle in normal and hypophysectomized rats were significantly increased following the compensatory overload. In the proximal part, fiber areas of type I, IIA, and IIC were significantly increased, but fiber area of type IIB did not change. IGF-I mRNA expressions in the distal and proximal parts were increased 3 d after the compensatory overload in normal and hypophysectomized rats. The increase of IGF-I mRNA expression in the distal part 3 d after compensatory overload was greater than those in the proximal part. IGF-I mRNA expressions in the distal and proximal parts were increased 14 d after the compensatory overload in hypophysectomized rats, but not in normal rats. GH receptor mRNA expressions were decreased following compensatory overload, and almost disappeared 14 d after the compensatory overload in hypophysectomized rats. Thus muscle fiber hypertrophy following compensatory overload was different among the parts in a muscle and IGF-I mRNA was expressed in concert with the region-specific hypertrophy, but not GH receptor mRNA.

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Local Changes of IGF-I mRNA, GH Receptor mRNA, and Fiber Size in Rat Plantaris Muscle Following Compensatory Overload.

Yamaguchi

Ikeda²,

Hirai³

et al. 2003

JJP

Self Cite

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“…The presence of GH receptors was also demonstrated in the central nervous system, including the choroid plexus, hippocampus, and hypothalamus (6 -8). Our previous work (9) has shown that expression of GH receptor messenger RNA (mRNA) in the brain is regulated by restraint stress in the water (RSW).…”

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confidence: 99%

The Growth Hormone (GH) Gene Is Expressed in the Lateral Hypothalamus: Enhancement by GH-Releasing Hormone and Repression by Restraint Stress

et al. 1998

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Recent studies suggest that GH may modulate emotion, behavior, or stress response by its direct actions on the brain, and possible expression of the GH gene in the brain has been predicted. In this study we have investigated whether and where the GH gene is expressed in the brain and how it is regulated. Ribonuclease protection assay and 5'-rapid amplification of complementary DNA ends-PCR analyses indicated that the GH gene was expressed in rat brain, initiating at the identical transcription start point as that for pituitary GH gene expression. The brain GH messenger RNA was predominantly detected in the lateral hypothalamus (lh) by in situ reverse transcription-PCR analysis. GH gene expression in the brain was significantly enhanced by GH-releasing hormone administration and was rapidly repressed by exposure to restraint stress in the water, whereas the changes in pituitary GH messenger RNA contents in these circumstances were relatively smaller. The results of the present study suggest that the brain GH is predominantly expressed in lh under the control of physiological conditions to play a role in the modulation of brain functions.

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A biphasic regulation of receptor mRNA expressions for growth hormone, glucocorticoid and mineralocorticoid in the rat dentate gyrus during acute stress

et al. 2000

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Dynamic Alterations in Growth Hormone Receptor mRNA Levels in Rat Brain During Stress Tolerance.

Cited by 4 publications

References 14 publications

Local Changes of IGF-I mRNA, GH Receptor mRNA, and Fiber Size in Rat Plantaris Muscle Following Compensatory Overload.

Local Changes of IGF-I mRNA, GH Receptor mRNA, and Fiber Size in Rat Plantaris Muscle Following Compensatory Overload.

The Growth Hormone (GH) Gene Is Expressed in the Lateral Hypothalamus: Enhancement by GH-Releasing Hormone and Repression by Restraint Stress

A biphasic regulation of receptor mRNA expressions for growth hormone, glucocorticoid and mineralocorticoid in the rat dentate gyrus during acute stress

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