Dynamic alterations of functional connectivity and amplitude of low-frequency fluctuations in patients with unilateral sudden sensorineural hearing loss

Li, Yuting; Chen, Jiawei; Yan, Lin‐Feng; Hu, Bo; Chen, Tian-Qi; Chen, Zhuhong; Sun, Jing-Ting; Shang, Yu‐Xuan; Lu, Lianjun; Cui, Guangbin; Wang, Wen

doi:10.1016/j.neulet.2022.136470

Cited by 8 publications

(5 citation statements)

References 36 publications

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“…Guo et al ( 21 ) found brain functional alterations as indicated by rs-fMRI ReHo values in the brain regions related to auditory, visual, motor, and cognitive function in children with CSNHL. In addition, a study ( 22 ) showed that sensorineural hearing loss (SNHL) patients displayed abnormal dALFF value in related visual cortices, and these findings suggest that SSNHL patients experience cross-modal plasticity and visual compensation, which may be closely related to the pathophysiology of SNHL. For FC studies, in children with severe SNHL without cochlear implants, the primary auditory cortex was found to have fewer FC to the motor cortex, while the visual cortex had more FC to the motor cortex and speech cortex ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

Cerebral cortex functional reorganization in preschool children with congenital sensorineural hearing loss: a resting-state fMRI study

Yin,

Lyu,

Zhou

et al. 2024

Front. Neurol.

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PurposeHow cortical functional reorganization occurs after hearing loss in preschool children with congenital sensorineural hearing loss (CSNHL) is poorly understood. Therefore, we used resting-state functional MRI (rs-fMRI) to explore the characteristics of cortical reorganization in these patents.MethodsSixty-three preschool children with CSNHL and 32 healthy controls (HCs) were recruited, and the Categories of Auditory Performance (CAP) scores were determined at the 6-month follow-up after cochlear implantation (CI). First, rs-fMRI data were preprocessed, and amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were calculated. Second, whole-brain functional connectivity (FC) analysis was performed using bilateral primary auditory cortex as seed points. Finally, Spearman correlation analysis was performed between the differential ALFF, ReHo and FC values and the CAP score.ResultsALFF analysis showed that preschool children with CSNHL had lower ALFF values in the bilateral prefrontal cortex and superior temporal gyrus than HCs, but higher ALFF values in the bilateral thalamus and calcarine gyrus. And correlation analysis showed that some abnormal brain regions were weak negatively correlated with CAP score (p < 0.05). The ReHo values in the bilateral superior temporal gyrus, part of the prefrontal cortex and left insular gyrus were lower, whereas ReHo values in the bilateral thalamus, right caudate nucleus and right precentral gyrus were higher, in children with CSNHL than HCs. However, there was no correlation between ReHo values and the CAP scores (p < 0.05). Using primary auditory cortex (PAC) as seed-based FC further analysis revealed enhanced FC in the visual cortex, proprioceptive cortex and motor cortex. And there were weak negative correlations between the FC values in the bilateral superior temporal gyrus, occipital lobe, left postcentral gyrus and right thalamus were weakly negatively correlated and the CAP score (p < 0.05).ConclusionAfter auditory deprivation in preschool children with CSNHL, the local functions of auditory cortex, visual cortex, prefrontal cortex and somatic motor cortex are changed, and the prefrontal cortex plays a regulatory role in this process. There is functional reorganization or compensation between children’s hearing and these areas, which may not be conducive to auditory language recovery after CI in deaf children.

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Section: Introductionmentioning

confidence: 99%

Cerebral cortex functional reorganization in preschool children with congenital sensorineural hearing loss: a resting-state fMRI study

Yin,

Lyu,

Zhou

et al. 2024

Front. Neurol.

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“…By employing dynamic ALFF analysis, it has been observed that individuals with SSHL demonstrate decreased dynamic ALFF variability specifically in the bilateral inferior occipital gyrus, middle occipital gyrus, calcarine, right lingual gyrus, and right fusiform gyrus ( Li et al, 2022 ). These findings indicate that SSHL patients may undergo cross-modal plasticity and visual compensation, which could be closely linked to the underlying pathophysiology of SSHL ( Li et al, 2022 ). Therefore, studying these dynamic characteristics can potentially reveal additional pathological changes associated with SSHL and provide valuable guidance for more effective treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Altered static and dynamic intrinsic brain activity in unilateral sudden sensorineural hearing loss

Li,

Yu,

Zou

et al. 2023

Front. Neurosci.

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IntroductionSudden sensorineural hearing loss (SSHL) is a critical otologic emergency characterized by a rapid decline of at least 30 dB across three consecutive frequencies in the pure-tone audiogram within a 72-hour period. This audiological condition has been associated with alterations in brain cortical and subcortical structures, as well as changes in brain functional activities involving multiple networks. However, the extent of cerebral intrinsic brain activity disruption in SSHL remains poorly understood. The aimed of this study is to investigate intrinsic brain activity alterations in SSHL using static and dynamic fractional amplitude of low-frequency fluctuation (fALFF) analysis.MethodsResting-state functional magnetic resonance imaging (fMRI) data were acquired from a cohort of SSHL patients (unilateral, n = 102) and healthy controls (n = 73). Static and dynamic fALFF methods were employed to analyze the acquired fMRI data, enabling a comprehensive examination of intrinsic brain activity changes in SSHL.ResultsOur analysis revealed significant differences in static fALFF patterns between SSHL patients and healthy controls. SSHL patients exhibited decreased fALFF in the left fusiform gyrus, left precentral gyrus, and right inferior frontal gyrus, alongside increased fALFF in the left inferior frontal gyrus, left superior frontal gyrus, and right middle temporal gyrus. Additionally, dynamic fALFF analysis demonstrated elevated fALFF in the right superior frontal gyrus and right middle frontal gyrus among SSHL patients. Intriguingly, we observed a positive correlation between static fALFF in the left fusiform gyrus and the duration of hearing loss, shedding light on potential temporal dynamics associated with intrinsic brain activity changes.DiscussionThe observed disruptions in intrinsic brain activity and temporal dynamics among SSHL patients provide valuable insights into the functional reorganization and potential compensatory mechanisms linked to hearing loss. These findings underscore the importance of understanding the underlying neural alterations in SSHL, which could pave the way for the development of targeted interventions and rehabilitation strategies aimed at optimizing SSHL management.

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“…Additionally, 1/3 of worldwide hearing loss patients had severe impairment [ World Health Organization [WHO], 2021 ]. Sudden sensorineural hearing loss (SNHL) is one of otologic emergency, which is defined as hearing loss in three consecutive frequencies within 3 days ( Li et al, 2022 ). More than 80% of SNHL patients have been found to be accompanied by tinnitus which often lasts for > 6 months ( Diao et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus

Hua

et al. 2022

Front. Neurosci.

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Few researchers investigated the topological properties and relationships with cognitive deficits in sudden sensorineural hearing loss (SNHL) with tinnitus. To explore the topological characteristics of the brain connectome following SNHL from the global level and nodal level, we recruited 36 bilateral SNHL patients with tinnitus and 37 well-matched healthy controls. Every subject underwent pure tone audiometry tests, neuropsychological assessments, and MRI scanning. AAL atlas was employed to divide a brain into 90 cortical and subcortical regions of interest, then investigated the global and nodal properties of “small world” network in SNHL and control groups using a graph-theory analysis. The global characteristics include small worldness, cluster coefficient, characteristic path length, local efficiency, and global efficiency. Node properties include degree centrality, betweenness centrality, nodal efficiency, and nodal clustering coefficient. Interregional connectivity analysis was also computed among 90 nodes. We found that the SNHL group had significantly higher hearing thresholds and cognitive impairments, as well as disrupted internal connections among 90 nodes. SNHL group displayed lower AUC of cluster coefficient and path length lambda, but increased global efficiency. The opercular and triangular parts of the inferior frontal gyrus, rectus gyrus, parahippocampal gyrus, precuneus, and amygdala showed abnormal local features. Some of these connectome alterations were correlated with cognitive ability and the duration of SNHL. This study may prove potential imaging biomarkers and treatment targets for future studies.

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Dynamic alterations of functional connectivity and amplitude of low-frequency fluctuations in patients with unilateral sudden sensorineural hearing loss

Cited by 8 publications

References 36 publications

Cerebral cortex functional reorganization in preschool children with congenital sensorineural hearing loss: a resting-state fMRI study

Cerebral cortex functional reorganization in preschool children with congenital sensorineural hearing loss: a resting-state fMRI study

Altered static and dynamic intrinsic brain activity in unilateral sudden sensorineural hearing loss

Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus

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