Dynamic alterations of the mice gut virome after <i>Coxsackievirus</i> B3 infection

Bao, Siwen; Wang, Hao; Li, Wang; Ji, Likai; Wang, Xiaochun; Shen, Qing; Yang, Shixing; Zhou, Chenglin; Zhang, Wen

doi:10.1002/jmv.27946

Cited by 4 publications

(2 citation statements)

References 50 publications

(83 reference statements)

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“…Microviridae are a group of small, circular, single-stranded DNA viruses that primarily infect bacteria and are commonly found among ssDNA phages. The Major Capsid Protein (MCP) genes, which are a conserved structural domain, serve as the main region of study for the Microviridae [ 28 ]. In this study, we identified and de novo assembled 62 sequences with complete MCP regions from the viral reads obtained from 197 DNA libraries of the Microviridae .…”

Section: Resultsmentioning

confidence: 99%

Differences between the intestinal microbial communities of healthy dogs from plateau and those of plateau dogs infected with Echinococcus

Liu,

Jiang,

Lei

et al. 2024

Virol J

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Objective Cystic echinococcosis (CE) represents a profoundly perilous zoonotic disease. The advent of viral macrogenomics has facilitated the exploration of hitherto uncharted viral territories. In the scope of this investigation, our objective is to scrutinize disparities in the intestinal microbiotic ecosystems of canines dwelling in elevated terrains and those afflicted by Echinococcus infection, employing the tool of viral macrogenomics. Methods In this study, we collected a comprehensive total of 1,970 fecal samples from plateau dogs infected with Echinococcus, as well as healthy control plateau dogs from the Yushu and Guoluo regions in the highland terrain of China. These samples were subjected to viral macrogenomic analysis to investigate the viral community inhabiting the canine gastrointestinal tract. Results Our meticulous analysis led to the identification of 136 viral genomic sequences, encompassing eight distinct viral families. Conclusion The outcomes of this study hold the potential to enhance our comprehension of the intricate interplay between hosts, parasites, and viral communities within the highland canine gut ecosystem. Through the examination of phage presence, it may aid in early detection or assessment of infection severity, providing valuable insights into Echinococcus infection and offering prospects for potential treatment strategies.

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Section: Resultsmentioning

confidence: 99%

Differences between the intestinal microbial communities of healthy dogs from plateau and those of plateau dogs infected with Echinococcus

Liu,

Jiang,

Lei

et al. 2024

Virol J

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“… 22 The previous study showed that the Coxsackievirus -infected mouse gut virome changed vastly and had significant alterations in the alpha diversity and beta diversity during the progression of virus infection. 23 Lu et al identified a significantly lower alpha diversity of the gut virome in diarrheal dairy calves. 24 The study by the team of Becerra revealed the dissimilarity of the gut virome of diarrheal children.…”

Section: Discussionmentioning

confidence: 99%

Viral metagenomics of the gut virome of diarrheal children with Rotavirus A infection

Bao

Wang

et al. 2023

Gut Microbes

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Diarrhea is a leading cause of morbidity and mortality in children worldwide and represents a major dysbiosis event. Rotavirus has been recognized as a global leading pathogen of diarrhea. This study is aimed at investigating differences in the gut virome between diarrheal children and healthy controls. In 2018, 76 diarrheal fecal samples and 27 healthy fecal samples in Shanghai and 40 diarrheal fecal samples and 19 healthy fecal samples in Taizhou were collected to investigate the composition of the gut virome. Viral metagenomic analyses revealed that the alpha diversity of the diarrheal virome was not significantly different from that of the healthy virome, and the beta diversity had a significant difference between diarrheal and healthy children. The diarrheal virome was mainly dominated by the families Adenoviridae , Astroviridae , Caliciviridae , and Picornaviridae . Meanwhile, the healthy virome also contains phages, including Microviridae and Caudovirales . The high prevalence of diverse enteric viruses in all samples and the little abundance of Microviridae and Caudovirales in diarrheal groups were identified. The study introduced a general overview of the gut virome in diarrheal children, revealed the compositional differences in the gut viral community compared to healthy controls, and provided a reference for efficient treatments and prevention of virus-infectious diarrhea in children.

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Phage as signatures of healthy microbiomes

Wheatley,

Holtappels,

Koskella

2024

Preprint

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Parasites are foundational to ecosystem health both as indicator species of community productivity but also as drivers of diversity. In bacterial communities, bacteriophage viruses can play such a role as they track the dynamic composition of bacterial hosts, and in the case of lytic phages, confer a growth advantage to lower abundance bacteria while adapting to more common ones. We set out to test whether viromes can be used as signatures of microbiome health using previously published results across systems. By comparing observed phage and bacterial diversity between microbiomes characterized by disturbance (so-called dysbiosis) and those considered control populations, we were able to identify some key commonalities. While just under half of studies report significant changes in viral species richness in dysbiosis, just under two thirds of studies find the viral composition to shift in dysbiosis, with specific viral taxa enrichment acting as a common signature of dysbiosis. Our analyses also suggest that the positive relationship between bacteriome and virome alpha diversity observed in health breaks down under microbiome disturbance. Overall, while specific viral signatures of dysbiosis are likely to be highly disease- and condition-specific, existing ecological theory shows clear promise in predicting and explaining microbiome health. Future data on bacteria-phage diversity relationships may provide us with much needed opportunity to diagnose, treat, and better understand the causes of dysbiosis.

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Dynamic alterations of the mice gut virome after Coxsackievirus B3 infection

Cited by 4 publications

References 50 publications

Differences between the intestinal microbial communities of healthy dogs from plateau and those of plateau dogs infected with Echinococcus

Differences between the intestinal microbial communities of healthy dogs from plateau and those of plateau dogs infected with Echinococcus

Viral metagenomics of the gut virome of diarrheal children with Rotavirus A infection

Phage as signatures of healthy microbiomes

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