Dynamic Amygdala Nuclei Alterations in Relation to Weight Status in Anorexia Nervosa Are Mediated by Leptin

Wronski, Marie-Louis; Bernardoni, Fabio; Bahnsen, Klaas; Seidel, Maria; Arold, Dominic; Doose, Arne; Steinhäuser, Jonas L.; Borucki, Katrin; Breithaupt, Lauren; Lawson, Elizabeth A.; Holsen, Laura M.; Weidner, Kerstin; Roessner, Veit; King, Joseph A.; Plessow, Franziska; Ehrlich, Stefan

doi:10.1016/j.jaac.2023.08.015

Journal of the American Academy of Child & Adolescent Psych

2024

DOI: 10.1016/j.jaac.2023.08.015

|View full text |Cite

Dynamic Amygdala Nuclei Alterations in Relation to Weight Status in Anorexia Nervosa Are Mediated by Leptin

Marie-Louis Wronski,

Fabio Bernardoni,

Klaas Bahnsen

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Does hypoleptinemia trigger entrapment in anorexia nervosa? Etiological and clinical considerations

Hebebrand,

Plieger,

Milos

et al. 2024

Euro Eating Disorders Rev

View full text Add to dashboard Cite

Based on the recent observation that human recombinant leptin (r‐Met‐hu‐leptin; metreleptin) may induce a profound alleviation of the complex symptomatology of patients with anorexia nervosa (AN), we examine the implications for our conceptualisation of this eating disorder. Hypoleptinemia as a core endocrine feature of AN serves as a central and peripheral trigger of tissue‐specific adaptations to starvation. In this narrative review, we argue that leptin deficiency may explain many of the puzzling features of this eating disorder. Weight loss can be viewed as a two‐step process, with only the second step entailing hypoleptinemia and thereby the entrapment characteristic of AN. We discuss the central and peripheral distribution of leptin receptors and consider possible functional implications of hypoleptinemia. We contrast the slow psychological recovery of patients with AN and of people who experienced starvation upon weight recovery with the rapid onset of improvements upon off‐label metreleptin treatment. Characteristics of the sex and age dependent secretion of leptin may contribute to the elevated vulnerability of young females to develop AN.

show abstract

Does hypoleptinemia trigger entrapment in anorexia nervosa? Etiological and clinical considerations

Hebebrand,

Plieger,

Milos

et al. 2024

Euro Eating Disorders Rev

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Dynamic Amygdala Nuclei Alterations in Relation to Weight Status in Anorexia Nervosa Are Mediated by Leptin

Cited by 1 publication

References 61 publications

Does hypoleptinemia trigger entrapment in anorexia nervosa? Etiological and clinical considerations

Does hypoleptinemia trigger entrapment in anorexia nervosa? Etiological and clinical considerations

Contact Info

Product

Resources

About